Increasing hyperpolarized spin lifetimes through true singlet eigenstates.

Journal Article (Journal Article)

The sensitivity limitations for magnetic resonance imaging of organic molecules have recently been addressed by hyperpolarization methods, which prepare excess nuclear spin polarization. This approach can increase sensitivity by orders of magnitude, but the enhanced signal relaxes away in tens of seconds, even in favorable cases. Here we show theoretically that singlet states between strongly coupled spins in molecules can be used to store and retrieve population in very-long-lived disconnected eigenstates, as long as the coupling between the spins substantially exceeds both the couplings to other spins and the resonance frequency difference between them. Experimentally, 2,3-carbon-13-labeled diacetyl has a disconnected eigenstate that can store population for minutes and is read out by hydration to make the two spins inequivalent.

Full Text

Duke Authors

Cited Authors

  • Warren, WS; Jenista, E; Branca, RT; Chen, X

Published Date

  • March 2009

Published In

Volume / Issue

  • 323 / 5922

Start / End Page

  • 1711 - 1714

PubMed ID

  • 19325112

Pubmed Central ID

  • PMC3080756

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1167693


  • eng