Increasing hyperpolarized spin lifetimes through true singlet eigenstates.
Journal Article (Journal Article)
The sensitivity limitations for magnetic resonance imaging of organic molecules have recently been addressed by hyperpolarization methods, which prepare excess nuclear spin polarization. This approach can increase sensitivity by orders of magnitude, but the enhanced signal relaxes away in tens of seconds, even in favorable cases. Here we show theoretically that singlet states between strongly coupled spins in molecules can be used to store and retrieve population in very-long-lived disconnected eigenstates, as long as the coupling between the spins substantially exceeds both the couplings to other spins and the resonance frequency difference between them. Experimentally, 2,3-carbon-13-labeled diacetyl has a disconnected eigenstate that can store population for minutes and is read out by hydration to make the two spins inequivalent.
Full Text
Duke Authors
Cited Authors
- Warren, WS; Jenista, E; Branca, RT; Chen, X
Published Date
- March 2009
Published In
Volume / Issue
- 323 / 5922
Start / End Page
- 1711 - 1714
PubMed ID
- 19325112
Pubmed Central ID
- PMC3080756
Electronic International Standard Serial Number (EISSN)
- 1095-9203
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.1167693
Language
- eng