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Increasing hyperpolarized spin lifetimes through true singlet eigenstates.

Publication ,  Journal Article
Warren, WS; Jenista, E; Branca, RT; Chen, X
Published in: Science (New York, N.Y.)
March 2009

The sensitivity limitations for magnetic resonance imaging of organic molecules have recently been addressed by hyperpolarization methods, which prepare excess nuclear spin polarization. This approach can increase sensitivity by orders of magnitude, but the enhanced signal relaxes away in tens of seconds, even in favorable cases. Here we show theoretically that singlet states between strongly coupled spins in molecules can be used to store and retrieve population in very-long-lived disconnected eigenstates, as long as the coupling between the spins substantially exceeds both the couplings to other spins and the resonance frequency difference between them. Experimentally, 2,3-carbon-13-labeled diacetyl has a disconnected eigenstate that can store population for minutes and is read out by hydration to make the two spins inequivalent.

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Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

March 2009

Volume

323

Issue

5922

Start / End Page

1711 / 1714

Related Subject Headings

  • Sensitivity and Specificity
  • Nuclear Magnetic Resonance, Biomolecular
  • Molecular Structure
  • Magnetics
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • General Science & Technology
  • Diacetyl
  • Chemical Phenomena
  • Carbon Isotopes
 

Citation

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Warren, W. S., Jenista, E., Branca, R. T., & Chen, X. (2009). Increasing hyperpolarized spin lifetimes through true singlet eigenstates. Science (New York, N.Y.), 323(5922), 1711–1714. https://doi.org/10.1126/science.1167693
Warren, Warren S., Elizabeth Jenista, Rosa Tamara Branca, and Xin Chen. “Increasing hyperpolarized spin lifetimes through true singlet eigenstates.Science (New York, N.Y.) 323, no. 5922 (March 2009): 1711–14. https://doi.org/10.1126/science.1167693.
Warren WS, Jenista E, Branca RT, Chen X. Increasing hyperpolarized spin lifetimes through true singlet eigenstates. Science (New York, NY). 2009 Mar;323(5922):1711–4.
Warren, Warren S., et al. “Increasing hyperpolarized spin lifetimes through true singlet eigenstates.Science (New York, N.Y.), vol. 323, no. 5922, Mar. 2009, pp. 1711–14. Epmc, doi:10.1126/science.1167693.
Warren WS, Jenista E, Branca RT, Chen X. Increasing hyperpolarized spin lifetimes through true singlet eigenstates. Science (New York, NY). 2009 Mar;323(5922):1711–1714.
Journal cover image

Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

March 2009

Volume

323

Issue

5922

Start / End Page

1711 / 1714

Related Subject Headings

  • Sensitivity and Specificity
  • Nuclear Magnetic Resonance, Biomolecular
  • Molecular Structure
  • Magnetics
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • General Science & Technology
  • Diacetyl
  • Chemical Phenomena
  • Carbon Isotopes