The effects of intravitreal triamcinolone acetonide on experimental pre-retinal neovascularization.

Published

Journal Article

Corticosteroids, alone or in combination with other drugs, have been shown to inhibit angiogenesis. The purpose of this study was to evaluate the efficacy of triamcinolone acetonide in a new model of preretinal neovascularization. Rabbit eyes were treated with intravitreal triamcinolone acetonide 24 h before partial liquefaction of the posterior vitreous with hyaluronidase and injection of 250,000 homologous tissue-cultured dermal fibroblasts. Triamcinolone acetonide effectively inhibited new vessel growth in treated eyes. Only 14% of the treated eyes developed new blood vessels compared to 100% of sham-injected control eyes (P < 0.001). These results suggest that intravitreal triamcinolone acetonide might be effective in inhibiting new vessel growth in patients with inflammatory retinal neovascularization, such as that associated with sarcoidosis or other uveitic syndromes.

Full Text

Duke Authors

Cited Authors

  • Antoszyk, AN; Gottlieb, JL; Machemer, R; Hatchell, DL

Published Date

  • 1993

Published In

Volume / Issue

  • 231 / 1

Start / End Page

  • 34 - 40

PubMed ID

  • 8428678

Pubmed Central ID

  • 8428678

International Standard Serial Number (ISSN)

  • 0721-832X

Digital Object Identifier (DOI)

  • 10.1007/bf01681698

Language

  • eng

Conference Location

  • Germany