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The effects of intravitreal triamcinolone acetonide on experimental pre-retinal neovascularization.

Publication ,  Journal Article
Antoszyk, AN; Gottlieb, JL; Machemer, R; Hatchell, DL
Published in: Graefes Arch Clin Exp Ophthalmol
1993

Corticosteroids, alone or in combination with other drugs, have been shown to inhibit angiogenesis. The purpose of this study was to evaluate the efficacy of triamcinolone acetonide in a new model of preretinal neovascularization. Rabbit eyes were treated with intravitreal triamcinolone acetonide 24 h before partial liquefaction of the posterior vitreous with hyaluronidase and injection of 250,000 homologous tissue-cultured dermal fibroblasts. Triamcinolone acetonide effectively inhibited new vessel growth in treated eyes. Only 14% of the treated eyes developed new blood vessels compared to 100% of sham-injected control eyes (P < 0.001). These results suggest that intravitreal triamcinolone acetonide might be effective in inhibiting new vessel growth in patients with inflammatory retinal neovascularization, such as that associated with sarcoidosis or other uveitic syndromes.

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Published In

Graefes Arch Clin Exp Ophthalmol

DOI

ISSN

0721-832X

Publication Date

1993

Volume

231

Issue

1

Start / End Page

34 / 40

Location

Germany

Related Subject Headings

  • Vitreous Body
  • Triamcinolone Acetonide
  • Retinal Neovascularization
  • Rabbits
  • Premedication
  • Ophthalmology & Optometry
  • Injections
  • Hyaluronoglucosaminidase
  • Fundus Oculi
  • Fluorescein Angiography
 

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Antoszyk, A. N., Gottlieb, J. L., Machemer, R., & Hatchell, D. L. (1993). The effects of intravitreal triamcinolone acetonide on experimental pre-retinal neovascularization. Graefes Arch Clin Exp Ophthalmol, 231(1), 34–40. https://doi.org/10.1007/BF01681698
Antoszyk, A. N., J. L. Gottlieb, R. Machemer, and D. L. Hatchell. “The effects of intravitreal triamcinolone acetonide on experimental pre-retinal neovascularization.Graefes Arch Clin Exp Ophthalmol 231, no. 1 (1993): 34–40. https://doi.org/10.1007/BF01681698.
Antoszyk AN, Gottlieb JL, Machemer R, Hatchell DL. The effects of intravitreal triamcinolone acetonide on experimental pre-retinal neovascularization. Graefes Arch Clin Exp Ophthalmol. 1993;231(1):34–40.
Antoszyk, A. N., et al. “The effects of intravitreal triamcinolone acetonide on experimental pre-retinal neovascularization.Graefes Arch Clin Exp Ophthalmol, vol. 231, no. 1, 1993, pp. 34–40. Pubmed, doi:10.1007/BF01681698.
Antoszyk AN, Gottlieb JL, Machemer R, Hatchell DL. The effects of intravitreal triamcinolone acetonide on experimental pre-retinal neovascularization. Graefes Arch Clin Exp Ophthalmol. 1993;231(1):34–40.
Journal cover image

Published In

Graefes Arch Clin Exp Ophthalmol

DOI

ISSN

0721-832X

Publication Date

1993

Volume

231

Issue

1

Start / End Page

34 / 40

Location

Germany

Related Subject Headings

  • Vitreous Body
  • Triamcinolone Acetonide
  • Retinal Neovascularization
  • Rabbits
  • Premedication
  • Ophthalmology & Optometry
  • Injections
  • Hyaluronoglucosaminidase
  • Fundus Oculi
  • Fluorescein Angiography