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Data analysis: evaluation of nanoscale contrast agent enhanced CT scan to differentiate between benign and malignant lung cancer in mouse model.

Publication ,  Journal Article
Bell, RC; Rogith, D; Johnson, CW; Badea, CT; Athreya, KK; Espinosa, G; Clark, D; Ghafoori, AP; Li, Y; Kirsch, DG; Annapragada, A; Ghaghada, K
Published in: AMIA Annu Symp Proc
2012

Proposed is a method for statistical analysis for a small sample size, repeated measure experiment with nesting factors. In the original experiment the Student t-test was used for analysis. Using the same data, we modeled the experiment into two groups of mice with benign and malignant primary lung tumors. 4 tumor nodules were selected from each mouse (N= 36). The dependent variables are the volume, diameter, and signal attenuation measured using computed tomography (CT). The measurements are made before injecting the contrast and at 0, 72, and 168 hours after injection. The contrast agent enhances tumor nodule volume and volume differences between benign and malignant tumor nodules measured across time (p < 0.05). The signal attenuation measured across time differentiates between benign and malignant groups (p < 0.05). There is significant correlation between rate of change of volume and diameter of tumor. The advantages of this statistical method are discussed.

Duke Scholars

Published In

AMIA Annu Symp Proc

EISSN

1942-597X

Publication Date

2012

Volume

2012

Start / End Page

27 / 35

Location

United States

Related Subject Headings

  • Tumor Burden
  • Tomography, X-Ray Computed
  • Proto-Oncogene Proteins p21(ras)
  • Nanoparticles
  • Mice
  • Lung Neoplasms
  • Liposomes
  • Disease Models, Animal
  • Diagnosis, Differential
  • Contrast Media
 

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Bell, R. C., Rogith, D., Johnson, C. W., Badea, C. T., Athreya, K. K., Espinosa, G., … Ghaghada, K. (2012). Data analysis: evaluation of nanoscale contrast agent enhanced CT scan to differentiate between benign and malignant lung cancer in mouse model. AMIA Annu Symp Proc, 2012, 27–35.
Bell, Robert C., Deevakar Rogith, Craig W. Johnson, Cristian T. Badea, Khannan K. Athreya, Gabriela Espinosa, Darin Clark, et al. “Data analysis: evaluation of nanoscale contrast agent enhanced CT scan to differentiate between benign and malignant lung cancer in mouse model.AMIA Annu Symp Proc 2012 (2012): 27–35.
Bell RC, Rogith D, Johnson CW, Badea CT, Athreya KK, Espinosa G, et al. Data analysis: evaluation of nanoscale contrast agent enhanced CT scan to differentiate between benign and malignant lung cancer in mouse model. AMIA Annu Symp Proc. 2012;2012:27–35.
Bell RC, Rogith D, Johnson CW, Badea CT, Athreya KK, Espinosa G, Clark D, Ghafoori AP, Li Y, Kirsch DG, Annapragada A, Ghaghada K. Data analysis: evaluation of nanoscale contrast agent enhanced CT scan to differentiate between benign and malignant lung cancer in mouse model. AMIA Annu Symp Proc. 2012;2012:27–35.

Published In

AMIA Annu Symp Proc

EISSN

1942-597X

Publication Date

2012

Volume

2012

Start / End Page

27 / 35

Location

United States

Related Subject Headings

  • Tumor Burden
  • Tomography, X-Ray Computed
  • Proto-Oncogene Proteins p21(ras)
  • Nanoparticles
  • Mice
  • Lung Neoplasms
  • Liposomes
  • Disease Models, Animal
  • Diagnosis, Differential
  • Contrast Media