Overview
- Our lab's research focus lies primarily in developing novel quantitative imaging systems, reconstruction algorithms and analysis methods. My major expertise is in preclinical CT.
- Currently, we are particularly interested in developing novel strategies for spectral CT imaging using nanoparticle-based contrast agents for theranostics (i.e. therapy and diagnostics).
- We are also engaged in developing new approaches for multidimensional CT image reconstruction suitable to address difficult undersampling cases in cardiac and spectral CT (dual energy and photon counting) using compressed sensing and/or deep learning.
- We are involved in co-clinical cancer trials and I have served as the Principal Investigator on the U24 Duke Preclinical Research Resources for Quantitative Imaging Biomarkers part of the NCI Co-Clinical Imaging Research Resources Program network (CIRP).
Current Appointments & Affiliations
Professor in Radiology
·
2021 - Present
Radiology,
Clinical Science Departments
Professor in the Department of Biomedical Engineering
·
2018 - Present
Biomedical Engineering,
Pratt School of Engineering
Member of the Duke Cancer Institute
·
2012 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Nanoparticle Contrast Agents for Photon-Counting Computed Tomography: Recent Developments and Future Opportunities.
Journal Article Wiley Interdiscip Rev Nanomed Nanobiotechnol · 2025 The clinical availability of photon-counting computed tomography (PCCT) has ushered in a new era of CT imaging. Spectral imaging coupled with superior contrast resolution, and ultrahigh spatial resolution (200 μm) offered by PCCT has the potential to revol ... Full text Link to item CiteInvestigating deep learning strategies for fast denoising of 5D cardiac photon-counting micro-CT images.
Journal Article Phys Med Biol · September 25, 2024 Photon-counting detectors (PCDs) for CT imaging use energy thresholds to simultaneously acquire projections at multiple energies, making them suitable for spectral imaging and material decomposition. Unfortunately, setting multiple energy thresholds r ... Full text Link to item CiteTurn-table micro-CT scanner for dynamic perfusion imaging in mice: design, implementation, and evaluation.
Journal Article Phys Med Biol · August 23, 2024 Objective.This study introduces a novel desktop micro-CT scanner designed for dynamic perfusion imaging in mice, aimed at enhancing preclinical imaging capabilities with high resolution and low radiation doses.Approach.The micro-CT system features a custom ... Full text Link to item CiteRecent Grants
Cardiac photon counting CT and its application in studying interactions between Alzheimer's and heart disease
ResearchPrincipal Investigator · Awarded by National Institute on Aging · 2021 - 2026Simulation Tools for 3D and 4D CT and Dosimetry
ResearchInvestigator · Awarded by National Institutes of Health · 2007 - 2025The Duke Pre-Clinical Research Resources for Quantitative Imaging Biomarkers
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2023View All Grants
Education, Training & Certifications
University of Patras (Greece) ·
2001
Ph.D.