Scholars@Duke
Cristian Tudorel Badea

Cristian Tudorel Badea

Professor in Radiology
Radiology
Cristian.Badea@duke.edu
Bryan Research Building, Room 161F, Durham, NC 27710
Manage Profile
Embed Profile Data

Selected Publications

Predicting brain age and associated structural networks in mouse models with humanized APOE alleles using integrative and interpretable graph neural networks

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2024 Alzheimer's disease (AD), a prevalent neurodegenerative disorder, is influenced by an intricate mix of risk factors including age, genetics, and environmental variables. In our study, we employed mouse models with human APOE alleles and nitric oxide syntha ... Full text Cite

High-resolution hybrid micro-CT imaging pipeline for mouse brain region segmentation and volumetric morphometry.

Journal Article PLoS One · 2024 BACKGROUND: Brain region segmentation and morphometry in humanized apolipoprotein E (APOE) mouse models with a human NOS2 background (HN) contribute to Alzheimer's disease (AD) research by demonstrating how various risk factors affect the brain. Photon-cou ... Full text Link to item Cite

Multi-Channel Reconstruction (MCR) Toolkit v2.0: open-source Python-based tools for X-ray CT reconstruction

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2024 Recently, we have released the first open-source version of our Multi-Channel CT Reconstruction (MCR) Toolkit (https://gitlab.oit.duke.edu/dpc18/mcr-toolkit-public). The initial release of the Toolkit represents 10 years of development and provides a compl ... Full text Cite

Advancing Preclinical Micro-Photon Counting CT Perfusion Imaging: From Phantom Experiments to In Vivo Applications

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2024 In preclinical studies, micro-CT is frequently employed to yield valuable anatomical insights. However, there has been an increasing need for micro-CT in extracting functional measurements such as with perfusion imaging. Perfusion imaging plays a crucial r ... Full text Cite

Denoising pediatric cardiac photon-counting CT data using volumetric vision transformers and unpaired training data

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2024 The advent of clinical photon counting x-ray CT (PCCT) has yielded gains in spatial resolution, noise performance, contrast resolution, and radiation dose management in numerous diagnostic applications. Pediatric populations, especially, stand to benefit f ... Full text Cite

Deep Learning Models for Rapid Denoising of 5D Cardiac Photon-Counting Micro-CT Images

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2024 Photon-counting detectors (PCDs) are advantageous for spectral CT imaging and material decomposition because they simultaneously acquire projections at multiple energies using energy thresholds. Unfortunately, the PCD produces noisy weighted filtered backp ... Full text Cite

An Acquisition-Based Approach for High-Fidelity Infilling of Photon-Counting X-ray Detector Pixel Gaps

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2024 Photon-counting detectors (PCDs) represent a technological advancement in X-ray CT imaging, bringing increased spatial resolution and spectral information to imaging in medical and industrial fields. Despite their potential, a critical issue arises from de ... Full text Cite

MR histology reveals tissue features beneath heterogeneous MRI signal in genetically engineered mouse models of sarcoma.

Journal Article Front Oncol · 2024 PURPOSE: To identify significant relationships between quantitative cytometric tissue features and quantitative MR (qMRI) intratumorally in preclinical undifferentiated pleomorphic sarcomas (UPS). MATERIALS AND METHODS: In a prospective study of geneticall ... Full text Link to item Cite

Leveraging 3D Bioprinting and Photon-Counting Computed Tomography to Enable Noninvasive Quantitative Tracking of Multifunctional Tissue Engineered Constructs.

Journal Article Adv Healthc Mater · December 2023 3D bioprinting is revolutionizing the fields of personalized and precision medicine by enabling the manufacturing of bioartificial implants that recapitulate the structural and functional characteristics of native tissues. However, the lack of quantitative ... Full text Link to item Cite

Evaluation of the impact of a novel denoising algorithm on image quality in dual-energy abdominal CT of obese patients.

Journal Article Eur Radiol · October 2023 OBJECTIVES: Evaluate a novel algorithm for noise reduction in obese patients using dual-source dual-energy (DE) CT imaging. METHODS: Seventy-nine patients with contrast-enhanced abdominal imaging (54 women; age: 58 ± 14 years; BMI: 39 ± 5 kg/m2, range: 35- ... Full text Open Access Link to item Cite

MCR toolkit: A GPU-based toolkit for multi-channel reconstruction of preclinical and clinical x-ray CT data.

Journal Article Med Phys · August 2023 BACKGROUND: The advancement of x-ray CT into the domains of photon counting spectral imaging and dynamic cardiac and perfusion imaging has created many new challenges and opportunities for clinicians and researchers. To address challenges such as dose cons ... Full text Open Access Link to item Cite

A Deep Learning Approach for Rapid and Generalizable Denoising of Photon-Counting Micro-CT Images.

Journal Article Tomography · July 2, 2023 Photon-counting CT (PCCT) is powerful for spectral imaging and material decomposition but produces noisy weighted filtered backprojection (wFBP) reconstructions. Although iterative reconstruction effectively denoises these images, it requires extensive com ... Full text Open Access Link to item Cite

Co-Clinical Imaging Metadata Information (CIMI) for Cancer Research to Promote Open Science, Standardization, and Reproducibility in Preclinical Imaging.

Journal Article Tomography · May 11, 2023 Preclinical imaging is a critical component in translational research with significant complexities in workflow and site differences in deployment. Importantly, the National Cancer Institute's (NCI) precision medicine initiative emphasizes the use of trans ... Full text Open Access Link to item Cite

Micro-CT imaging of multiple K-edge elements using GaAs and CdTe photon counting detectors.

Journal Article Phys Med Biol · April 12, 2023 Objective.To evaluate the performance of two photon-counting (PC) detectors based on different detector materials, gallium arsenide (GaAs) and cadmium telluride (CdTe), for PC micro-CT imaging of phantoms with multiple contrast materials. Another objective ... Full text Open Access Link to item Cite

Supplementary figure FS4 from Neoadjuvant Radiation Therapy and Surgery Improves Metastasis-Free Survival over Surgery Alone in a Primary Mouse Model of Soft Tissue Sarcoma

Other · April 3, 2023 <p>Long-term metastases study of an autochthonous p53/MCA mouse model of STS induced by Cre-LoxP technology using TRP53 fl/fl mice</p> ... Full text Cite

Supplementary figure FS4 from Neoadjuvant Radiation Therapy and Surgery Improves Metastasis-Free Survival over Surgery Alone in a Primary Mouse Model of Soft Tissue Sarcoma

Other · April 3, 2023 <p>Long-term metastases study of an autochthonous p53/MCA mouse model of STS induced by Cre-LoxP technology using TRP53 fl/fl mice</p> ... Full text Cite

Predicting brain age and associated structural networks in mouse models with humanized APOE alleles using integrative and interpretable graph neural networks

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2024 Alzheimer's disease (AD), a prevalent neurodegenerative disorder, is influenced by an intricate mix of risk factors including age, genetics, and environmental variables. In our study, we employed mouse models with human APOE alleles and nitric oxide syntha ... Full text Cite

High-resolution hybrid micro-CT imaging pipeline for mouse brain region segmentation and volumetric morphometry.

Journal Article PLoS One · 2024 BACKGROUND: Brain region segmentation and morphometry in humanized apolipoprotein E (APOE) mouse models with a human NOS2 background (HN) contribute to Alzheimer's disease (AD) research by demonstrating how various risk factors affect the brain. Photon-cou ... Full text Link to item Cite

Multi-Channel Reconstruction (MCR) Toolkit v2.0: open-source Python-based tools for X-ray CT reconstruction

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2024 Recently, we have released the first open-source version of our Multi-Channel CT Reconstruction (MCR) Toolkit (https://gitlab.oit.duke.edu/dpc18/mcr-toolkit-public). The initial release of the Toolkit represents 10 years of development and provides a compl ... Full text Cite

Advancing Preclinical Micro-Photon Counting CT Perfusion Imaging: From Phantom Experiments to In Vivo Applications

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2024 In preclinical studies, micro-CT is frequently employed to yield valuable anatomical insights. However, there has been an increasing need for micro-CT in extracting functional measurements such as with perfusion imaging. Perfusion imaging plays a crucial r ... Full text Cite

Denoising pediatric cardiac photon-counting CT data using volumetric vision transformers and unpaired training data

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2024 The advent of clinical photon counting x-ray CT (PCCT) has yielded gains in spatial resolution, noise performance, contrast resolution, and radiation dose management in numerous diagnostic applications. Pediatric populations, especially, stand to benefit f ... Full text Cite

Deep Learning Models for Rapid Denoising of 5D Cardiac Photon-Counting Micro-CT Images

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2024 Photon-counting detectors (PCDs) are advantageous for spectral CT imaging and material decomposition because they simultaneously acquire projections at multiple energies using energy thresholds. Unfortunately, the PCD produces noisy weighted filtered backp ... Full text Cite

An Acquisition-Based Approach for High-Fidelity Infilling of Photon-Counting X-ray Detector Pixel Gaps

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2024 Photon-counting detectors (PCDs) represent a technological advancement in X-ray CT imaging, bringing increased spatial resolution and spectral information to imaging in medical and industrial fields. Despite their potential, a critical issue arises from de ... Full text Cite

MR histology reveals tissue features beneath heterogeneous MRI signal in genetically engineered mouse models of sarcoma.

Journal Article Front Oncol · 2024 PURPOSE: To identify significant relationships between quantitative cytometric tissue features and quantitative MR (qMRI) intratumorally in preclinical undifferentiated pleomorphic sarcomas (UPS). MATERIALS AND METHODS: In a prospective study of geneticall ... Full text Link to item Cite

Leveraging 3D Bioprinting and Photon-Counting Computed Tomography to Enable Noninvasive Quantitative Tracking of Multifunctional Tissue Engineered Constructs.

Journal Article Adv Healthc Mater · December 2023 3D bioprinting is revolutionizing the fields of personalized and precision medicine by enabling the manufacturing of bioartificial implants that recapitulate the structural and functional characteristics of native tissues. However, the lack of quantitative ... Full text Link to item Cite

Evaluation of the impact of a novel denoising algorithm on image quality in dual-energy abdominal CT of obese patients.

Journal Article Eur Radiol · October 2023 OBJECTIVES: Evaluate a novel algorithm for noise reduction in obese patients using dual-source dual-energy (DE) CT imaging. METHODS: Seventy-nine patients with contrast-enhanced abdominal imaging (54 women; age: 58 ± 14 years; BMI: 39 ± 5 kg/m2, range: 35- ... Full text Open Access Link to item Cite

MCR toolkit: A GPU-based toolkit for multi-channel reconstruction of preclinical and clinical x-ray CT data.

Journal Article Med Phys · August 2023 BACKGROUND: The advancement of x-ray CT into the domains of photon counting spectral imaging and dynamic cardiac and perfusion imaging has created many new challenges and opportunities for clinicians and researchers. To address challenges such as dose cons ... Full text Open Access Link to item Cite

A Deep Learning Approach for Rapid and Generalizable Denoising of Photon-Counting Micro-CT Images.

Journal Article Tomography · July 2, 2023 Photon-counting CT (PCCT) is powerful for spectral imaging and material decomposition but produces noisy weighted filtered backprojection (wFBP) reconstructions. Although iterative reconstruction effectively denoises these images, it requires extensive com ... Full text Open Access Link to item Cite

Co-Clinical Imaging Metadata Information (CIMI) for Cancer Research to Promote Open Science, Standardization, and Reproducibility in Preclinical Imaging.

Journal Article Tomography · May 11, 2023 Preclinical imaging is a critical component in translational research with significant complexities in workflow and site differences in deployment. Importantly, the National Cancer Institute's (NCI) precision medicine initiative emphasizes the use of trans ... Full text Open Access Link to item Cite

Micro-CT imaging of multiple K-edge elements using GaAs and CdTe photon counting detectors.

Journal Article Phys Med Biol · April 12, 2023 Objective.To evaluate the performance of two photon-counting (PC) detectors based on different detector materials, gallium arsenide (GaAs) and cadmium telluride (CdTe), for PC micro-CT imaging of phantoms with multiple contrast materials. Another objective ... Full text Open Access Link to item Cite

Supplementary figure FS4 from Neoadjuvant Radiation Therapy and Surgery Improves Metastasis-Free Survival over Surgery Alone in a Primary Mouse Model of Soft Tissue Sarcoma

Other · April 3, 2023 <p>Long-term metastases study of an autochthonous p53/MCA mouse model of STS induced by Cre-LoxP technology using TRP53 fl/fl mice</p> ... Full text Cite

Supplementary figure FS4 from Neoadjuvant Radiation Therapy and Surgery Improves Metastasis-Free Survival over Surgery Alone in a Primary Mouse Model of Soft Tissue Sarcoma

Other · April 3, 2023 <p>Long-term metastases study of an autochthonous p53/MCA mouse model of STS induced by Cre-LoxP technology using TRP53 fl/fl mice</p> ... Full text Cite

Supplementary figure FS3 from Neoadjuvant Radiation Therapy and Surgery Improves Metastasis-Free Survival over Surgery Alone in a Primary Mouse Model of Soft Tissue Sarcoma

Other · April 3, 2023 <p>Long-term survival of an autochthonous p53/MCA mouse model in immunocompetent 129/SvJae wild-type mice induced by CRISPR/Cas9</p> ... Full text Cite

Supplementary figure FS3 from Neoadjuvant Radiation Therapy and Surgery Improves Metastasis-Free Survival over Surgery Alone in a Primary Mouse Model of Soft Tissue Sarcoma

Other · April 3, 2023 <p>Long-term survival of an autochthonous p53/MCA mouse model in immunocompetent 129/SvJae wild-type mice induced by CRISPR/Cas9</p> ... Full text Cite

Data from Neoadjuvant Radiation Therapy and Surgery Improves Metastasis-Free Survival over Surgery Alone in a Primary Mouse Model of Soft Tissue Sarcoma

Other · April 3, 2023 <div>Abstract<p>This study aims to investigate whether adding neoadjuvant radiotherapy (RT), anti-programmed cell death protein-1 (PD-1) antibody (anti–PD-1), or RT + anti-PD-1 to surgical resection improves disease-free survival for mi ... Full text Cite

Data from Neoadjuvant Radiation Therapy and Surgery Improves Metastasis-Free Survival over Surgery Alone in a Primary Mouse Model of Soft Tissue Sarcoma

Other · April 3, 2023 <div>Abstract<p>This study aims to investigate whether adding neoadjuvant radiotherapy (RT), anti-programmed cell death protein-1 (PD-1) antibody (anti–PD-1), or RT + anti-PD-1 to surgical resection improves disease-free survival for mi ... Full text Cite

An Online Repository for Pre-Clinical Imaging Protocols (PIPs).

Journal Article Tomography · March 27, 2023 Providing method descriptions that are more detailed than currently available in typical peer reviewed journals has been identified as an actionable area for improvement. In the biochemical and cell biology space, this need has been met through the creatio ... Full text Open Access Link to item Cite

Animal Models and Their Role in Imaging-Assisted Co-Clinical Trials.

Journal Article Tomography · March 16, 2023 The availability of high-fidelity animal models for oncology research has grown enormously in recent years, enabling preclinical studies relevant to prevention, diagnosis, and treatment of cancer to be undertaken. This has led to increased opportunities to ... Full text Open Access Link to item Cite

Neoadjuvant Radiation Therapy and Surgery Improves Metastasis-Free Survival over Surgery Alone in a Primary Mouse Model of Soft Tissue Sarcoma.

Journal Article Mol Cancer Ther · January 3, 2023 This study aims to investigate whether adding neoadjuvant radiotherapy (RT), anti-programmed cell death protein-1 (PD-1) antibody (anti-PD-1), or RT + anti-PD-1 to surgical resection improves disease-free survival for mice with soft tissue sarcomas (STS). ... Full text Open Access Link to item Cite

Unsupervised learning of robust models for cardiac and photon-counting x-ray CT denoising

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2023 Supervised deep learning methods have rapidly advanced to the forefront of medical imaging research; however, they face limitations in advanced CT applications. For instance, label generation is difficult for retrospective cardiac CT data where dose modula ... Full text Cite

Spectral micro-CT imaging of multiple K-edge elements using GaAs and CdTe photon counting detectors

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2023 Superior material discrimination provided by photon counting detector (PCD) technology promises to transform X-ray CT into a functional and molecular imaging modality while maintaining its high spatial resolution, fast scanning times, and relatively low co ... Full text Cite

Ex vivo high-resolution hybrid micro-CT imaging using photon counting and energy integrating detectors

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2023 Spectral micro-CT shows great potential to provide accurate material composition by utilizing the energy dependence of x-ray attenuation in different materials. This is especially well-suited for pre-clinical imaging using nanoparticle-based contrast agent ... Full text Cite

Advanced photon counting CT imaging pipeline for cardiac phenotyping of apolipoprotein E mouse models.

Journal Article PLoS One · 2023 BACKGROUND: Cardiovascular disease (CVD) is associated with the apolipoprotein E (APOE) gene and lipid metabolism. This study aimed to develop an imaging-based pipeline to comprehensively assess cardiac structure and function in mouse models expressing dif ... Full text Link to item Cite

Automated multimodal segmentation of acute ischemic stroke lesions on clinical MR images.

Journal Article Magn Reson Imaging · October 2022 Magnetic resonance (MR) imaging (MRI) is commonly used to diagnose, assess and monitor stroke. Accurate and timely segmentation of stroke lesions provides the anatomico-structural information that can aid physicians in predicting prognosis, as well as in d ... Full text Open Access Link to item Cite

Material decomposition from photon-counting CT using a convolutional neural network and energy-integrating CT training labels.

Journal Article Phys Med Biol · July 18, 2022 Featured Publication Objective.Photon-counting CT (PCCT) has better dose efficiency and spectral resolution than energy-integrating CT, which is advantageous for material decomposition. Unfortunately, the accuracy of PCCT-based material decomposition is limited due to spectral ... Full text Open Access Link to item Cite

Photon Counting CT and Radiomic Analysis Enables Differentiation of Tumors Based on Lymphocyte Burden.

Journal Article Tomography · March 10, 2022 Featured Publication The purpose of this study was to investigate if radiomic analysis based on spectral micro-CT with nanoparticle contrast-enhancement can differentiate tumors based on lymphocyte burden. High mutational load transplant soft tissue sarcomas were initiated in ... Full text Open Access Link to item Cite

Cardiac CT reconstruction for vendor-neutral virtual imaging trials

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2022 Cardiac CT imaging is invaluable in a variety of applications including non-invasive assessment of coronary artery calcifications, the ruling out of acute coronary artery syndrome, and the planning of valve replacement procedures. Newer applications includ ... Full text Cite

Photon Counting Micro-CT for Imaging Cisplatin

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2022 The photon-counting (PC) detector technology promises to enhance the number of CT applications due to the spectral information. Of high interest for the cancer research community is imaging the tumor delivery of Cisplatin (CisPt), a chemotherapeutic agent ... Full text Cite

Spectral micro-CT and nanoradiomic analysis for classification of tumors based on lymphocytic burden in cancer therapy studies

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2022 The purpose of this study was to investigate if radiomic analysis based on spectral micro-CT with nanoparticle contrast-enhancement can differentiate tumors based on tumor-infiltrating lymphocyte (TIL) burden. High mutational load transplant soft tissue sa ... Full text Cite

Volumetric, dual-domain x-ray CT reconstruction with deep learning

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2022 Novel deep learning (DL) methods have produced state-of-the-art results in nearly every area of x-ray CT data processing. However, DL-driven, iterative reconstruction remains challenging because of the volumetric nature of many reconstruction problems: the ... Full text Cite

Anatomical and functional cardiac PCCT imaging pipeline for characterization of Apolipoprotein E mouse models

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2022 Non-invasive imaging strategies are essential in understanding the factors associated with the ongoing rise in cardiovascular disease (CVD) and Alzheimer’s disease (AD), and the possible interactions between these diseases. Our scientific premise is based ... Full text Cite

Co-clinical photon counting CT research for multi-contrast imaging

Conference Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2022 Developing novel contrast agents for multi-energy photon-counting (PC)CT will require a clear translation pathway from preclinical validation to clinical applications. To begin this development, we have used a clinical PCCT scanner (Siemens NAEOTOM Alpha) ... Full text Cite

Photon-counting X-ray CT perfusion imaging in animal models of cancer

Conference Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2022 Photon-counting detector (PCD) CT promises to improve routine CT imaging applications with higher spatial resolution, lower levels of noise at fixed dose, and improved image contrast while providing spectral information with every scan. We propose and demo ... Full text Cite

Material Decomposition from Photon-Counting CT using a Convolutional Neural Network and Energy-Integrating CT Training Labels

Conference Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2022 Although photon counting detectors (PCD) can offer numerous benefits for CT imaging, it is difficult to generate accurate material decompositions from photon counting (PC) CT images due to spectral distortions. In this work, we present a deep learning (DL) ... Full text Cite

Principles of Micro X-ray Computed Tomography

Chapter · August 9, 2021 The most authoritative and comprehensive resource available in the molecular-imaging field, written by over 170 of the leading scientists from around the world who have evaluated and summarized the most important methods, principles, ... ... Full text Open Access Cite

Detection of Lung Nodules in Micro-CT Imaging Using Deep Learning.

Journal Article Tomography · August 7, 2021 Featured Publication We are developing imaging methods for a co-clinical trial investigating synergy between immunotherapy and radiotherapy. We perform longitudinal micro-computed tomography (micro-CT) of mice to detect lung metastasis after treatment. This work explores deep ... Full text Open Access Link to item Cite

Advances in micro-CT imaging of small animals.

Journal Article Phys Med · August 2021 Featured Publication PURPOSE: Micron-scale computed tomography (micro-CT) imaging is a ubiquitous, cost-effective, and non-invasive three-dimensional imaging modality. We review recent developments and applications of micro-CT for preclinical research. METHODS: Based on a comp ... Full text Open Access Link to item Cite

Evaluating renal lesions using deep-learning based extension of dual-energy FoV in dual-source CT-A retrospective pilot study.

Journal Article Eur J Radiol · June 2021 PURPOSE: Dual-source (DS) CT, dual-energy (DE) field of view (FoV) is limited to the size of the smaller detector array. The purpose was to establish a deep learning-based approach to DE extrapolation by estimating missing image data using data from both t ... Full text Open Access Link to item Cite

Ex Vivo MR Histology and Cytometric Feature Mapping Connect Three-dimensional in Vivo MR Images to Two-dimensional Histopathologic Images of Murine Sarcomas.

Journal Article Radiol Imaging Cancer · May 2021 Purpose To establish a platform for quantitative tissue-based interpretation of cytoarchitecture features from tumor MRI measurements. Materials and Methods In a pilot preclinical study, multicontrast in vivo MRI of murine soft-tissue sarcomas in 10 mice, ... Full text Open Access Link to item Cite

Characterization of cardiovascular injury in mice following partial-heart irradiation with clinically relevant dose and fractionation.

Journal Article Radiother Oncol · April 2021 BACKGROUND AND PURPOSE: Late cardiac toxicity is a major side effect of radiation therapy (RT) for breast cancer. We developed and characterized a mouse model of radiation-induced heart disease that mimics the dose, fractionation, and beam arrangement of l ... Full text Link to item Cite

Microcephaly with altered cortical layering in GIT1 deficiency revealed by quantitative neuroimaging.

Journal Article Magn Reson Imaging · February 2021 G Protein-Coupled Receptor Kinase-Interacting Protein-1 (GIT1) regulates neuronal functions, including cell and axon migration and synapse formation and maintenance, and GIT1 knockout (KO) mice exhibit learning and memory deficits. We noted that male and f ... Full text Link to item Cite

Deep learning based spectral distortion correction and decomposition for photon counting ct using calibration provided by an energy integrated detector

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2021 While the benefits of photon counting (PC) CT are significant, the performance of current PCDs is limited by physical effects distorting the spectral response. In this work, we examine a deep learning (DL) approach for spectral correction and material deco ... Full text Cite

A constrained bregman framework for unsupervised convolutional denoising of multi-channel x-ray ct data

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2021 Deep learning (DL) approaches to image denoising have advanced real-world performance in one of the most thoroughly studied areas of digital signal processing. Keys to the success of DL are data-driven approximation of an underlying signal model and non-li ... Full text Cite

Towards deep learning detection of lung nodules using micro-CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2021 We are developing imaging methods for the preclinical arm of a co-clinical trial investigating synergy between immunotherapy and radiotherapy. We perform in vivo micro-CT of mouse lungs to detect lung metastasis after treatment. This work explores deep lea ... Full text Cite

Dual source hybrid spectral micro-CT using an energy-integrating and a photon-counting detector.

Journal Article Phys Med Biol · October 21, 2020 Featured Publication Preclinical micro-CT provides a hotbed in which to develop new imaging technologies, including spectral CT using photon counting detector (PCD) technology. Spectral imaging using PCDs promises to expand x-ray CT as a functional imaging modality, capable of ... Full text Open Access Link to item Cite

Deep learning based spectral extrapolation for dual-source, dual-energy x-ray computed tomography.

Journal Article Med Phys · September 2020 PURPOSE: Data completion is commonly employed in dual-source, dual-energy computed tomography (CT) when physical or hardware constraints limit the field of view (FoV) covered by one of two imaging chains. Practically, dual-energy data completion is accompl ... Full text Open Access Link to item Cite

Co-Clinical Imaging Resource Program (CIRP): Bridging the Translational Divide to Advance Precision Medicine.

Journal Article Tomography · September 2020 The National Institutes of Health's (National Cancer Institute) precision medicine initiative emphasizes the biological and molecular bases for cancer prevention and treatment. Importantly, it addresses the need for consistency in preclinical and clinical ... Full text Open Access Link to item Cite

MRI-Based Deep Learning Segmentation and Radiomics of Sarcoma in Mice.

Journal Article Tomography · March 2020 Featured Publication Small-animal imaging is an essential tool that provides noninvasive, longitudinal insight into novel cancer therapies. However, considerable variability in image analysis techniques can lead to inconsistent results. We have developed quantitative imaging f ... Full text Open Access Link to item Cite

The impact of respiratory gating on improving volume measurement of murine lung tumors in micro-CT imaging.

Journal Article PLoS One · 2020 Small animal imaging has become essential in evaluating new cancer therapies as they are translated from the preclinical to clinical domain. However, preclinical imaging faces unique challenges that emphasize the gap between mouse and man. One example is t ... Full text Open Access Link to item Cite

Hybrid energy integrating and photon counting micro-CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2020 The maturation of photon-counting detector (PCD) technology promises to enhance routine CT applications with high-fidelity spectral information, transforming X-ray CT into a functional and molecular imaging modality, while maintaining the high spatial reso ... Full text Cite

Fast spectral x-ray CT reconstruction with data-adaptive, convolutional regularization

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2020 Advancements in deep learning and GPU computing have exponentially driven the application of neural networks to classic medical imaging problems: denoising, segmentation, artifact removal, etc. Deep learning solutions are particularly attractive for proces ... Full text Cite

Development of a spectral Micro-CT system using a photon counting detector with anti-coincidence corrections

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2020 There is potential to improve CT imaging by adding spectral capabilities as given by photon counting detectors (PCD). Here we describe and assess performance of a new spectral micro-CT prototype system using a CdTe-based PCD with 100-µm pixel size (model X ... Full text Cite

MRI-based radiomics of sarcomas in the preclinical arm of a Co-clinical trial

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2020 Radiomics provide an exciting approach to developing imaging biomarkers in the context of precision medicine. We focus on the preclinical arm of a co-clinical trial investigating synergy of immunotherapy combined with radiation therapy (RT) and surgical re ... Full text Cite

A spectral CT study on iodine augmentation of radiation therapy and its potential for combination with chemotherapy

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2020 High-Z based nanoparticles (NP) are emerging as promising agents for both cancer radiotherapy (RT) and CT imaging. NPs can be delivered to tumors via the enhanced permeability and retention (EPR) effect and they preferentially accumulate in tumor's perivas ... Full text Cite

The impact of respiratory gating on improving volume measurement of murine lung tumors in micro-CT imaging

Journal Article · October 29, 2019 ABSTRACTSmall animal imaging has become essential in evaluating new cancer therapies as they are translated from the preclinical to clinical domain. However, preclinical imaging faces unique challenges that emphasize the ga ... Full text Open Access Cite

Sensitization of Vascular Endothelial Cells to Ionizing Radiation Promotes the Development of Delayed Intestinal Injury in Mice.

Journal Article Radiat Res · September 2019 Exposure of the gastrointestinal (GI) tract to ionizing radiation can cause acute and delayed injury. However, critical cellular targets that regulate the development of radiation-induced GI injury remain incompletely understood. Here, we investigated the ... Full text Open Access Link to item Cite

Photon-counting cine-cardiac CT in the mouse

Journal Article · June 4, 2019 Abstract The maturation of photon-counting detector (PCD) technology promises to enhance routine CT imaging applications with high-fidelity spectral information. In this paper, we demonstrate the power of this synergy and our complementary reconstruction t ... Full text Cite

Vascular Endothelial Growth Factor Receptor 3 Regulates Endothelial Function Through β-Arrestin 1.

Journal Article Circulation · March 26, 2019 BACKGROUND: Receptor signaling is central to vascular endothelial function and is dysregulated in vascular diseases such as atherosclerosis and pulmonary arterial hypertension (PAH). Signaling pathways involved in endothelial function include vascular endo ... Full text Link to item Cite

Functional imaging of tumor vasculature using iodine and gadolinium-based nanoparticle contrast agents: a comparison of spectral micro-CT using energy integrating and photon counting detectors.

Journal Article Phys Med Biol · March 12, 2019 Advances in computed tomography (CT) hardware have propelled the development of novel CT contrast agents. In particular, the spectral capabilities of x-ray CT can facilitate simultaneous imaging of multiple contrast agents. This approach is particularly us ... Full text Open Access Link to item Cite

Overcoming detector limitations of x-ray photon counting for preclinical microcomputed tomography.

Journal Article J Med Imaging (Bellingham) · January 2019 Spectral computed tomography (CT) using photon counting detectors (PCDs) can provide accurate tissue composition measurements by utilizing the energy dependence of x-ray attenuation in different materials. PCDs are especially suited for K-edge imaging, rev ... Full text Open Access Link to item Cite

Bridging the translational gap: Implementation of multimodal small animal imaging strategies for tumor burden assessment in a co-clinical trial.

Journal Article PLoS One · 2019 Featured Publication In designing co-clinical cancer studies, preclinical imaging brings unique challenges that emphasize the gap between man and mouse. Our group is developing quantitative imaging methods for the preclinical arm of a co-clinical trial studying immunotherapy a ... Full text Open Access Link to item Cite

To gate or not to gate: An evaluation of respiratory gating techniques to improve volume measurement of murine lung tumors in micro-CT imaging

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2019 Small animal imaging has become essential in evaluating new cancer therapies as they are translated from the preclinical to clinical domain. However, preclinical imaging is faced with unique challenges that emphasize the gap between mouse and man. One exam ... Full text Cite

Multi-modal MRI segmentation of sarcoma tumors using convolutional neural networks

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2019 Small animal imaging is essential in building a bridge from basic science to the clinic by providing the confidence necessary to move new cancer therapies to patients. However, there is considerable variability in preclinical imaging, including tumor volum ... Full text Cite

Spectral data completion for dual-source x-ray CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2019 In the context of x-ray CT, data completion is the process of augmenting truncated projection data to avoid artifacts during reconstruction. Data completion is commonly employed in dual-source CT where physical or hardware constraints limit the field of vi ... Full text Cite

Convolutional regularization methods for 4D, x-ray CT reconstruction

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2019 Deep learning methods have shown great promise in tackling challenging medical imaging tasks. Within the field of x-ray CT, deep learning for image denoising is of interest because of the fundamental link between ionizing radiation dose and diagnostic imag ... Full text Cite

Photon-counting cine-cardiac CT in the mouse.

Journal Article PLoS One · 2019 Featured Publication The maturation of photon-counting detector (PCD) technology promises to enhance routine CT imaging applications with high-fidelity spectral information. In this paper, we demonstrate the power of this synergy and our complementary reconstruction techniques ... Full text Open Access Link to item Cite

Bridging the translational gap: Implementation of multimodal small animal imaging strategies for tumor burden assessment in a co-clinical trial

Journal Article · November 5, 2018 Abstract In designing co-clinical cancer studies, preclinical imaging brings unique challenges that emphasize the gap between man and mouse. Our group is developing quantitative imaging methods for the preclinical arm of a co-clinical trial studying immuno ... Full text Cite

Low-dose 4D cardiac imaging in small animals using dual source micro-CT.

Journal Article Phys Med Biol · January 9, 2018 Micro-CT is widely used in preclinical studies, generating substantial interest in extending its capabilities in functional imaging applications such as blood perfusion and cardiac function. However, imaging cardiac structure and function in mice is challe ... Full text Open Access Link to item Cite

Dual-Energy CT Imaging of Tumor Liposome Delivery After Gold Nanoparticle-Augmented Radiation Therapy.

Journal Article Theranostics · 2018 Featured Publication Gold nanoparticles (AuNPs) are emerging as promising agents for both cancer therapy and computed tomography (CT) imaging. AuNPs absorb x-rays and subsequently release low-energy, short-range photoelectrons during external beam radiation therapy (RT), incre ... Full text Open Access Link to item Cite

Data-efficient methods for multi-channel x-ray CT reconstruction

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2018 The superiority of iterative reconstruction techniques over analytical ones is documented in a variety of CT imaging applications. However, iterative reconstruction techniques generally require a substantial increase in data processing time and required re ... Full text Cite

Multiscale dual energy micro-CT for imaging using iodinated and gold nanoparticles

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2018 Dual energy (DE) micro-CT shows great potential to provide accurate tissue composition by utilizing the energy dependence of x-ray attenuation in different materials. This is especially well-suited for pre-clinical imaging using nanoparticle-based contrast ... Full text Cite

Multi-energy CT decomposition using convolutional neural networks

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2018 Spectral CT can provide accurate tissue composition measurements by utilizing the energy dependence of x-ray attenuation in different materials. We have introduced image reconstruction and material decomposition algorithms for multi-energy CT data acquired ... Full text Cite

Spectral imaging of iodine and gadolinium nanoparticles using dual-energy CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2018 Advances in CT hardware have propelled the development of novel CT contrast agents. Combined with the spectral capabilities of X-ray CT, molecular imaging is possible using multiple heavy-metal contrast agents. Nanoparticle platforms make particularly attr ... Full text Cite

Development of a spectral photon-counting micro-CT system with a translate-rotate geometry

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2018 Spectral CT using photon counting x-ray detectors (PCXDs) can provide accurate tissue composition measurements by utilizing the energy dependence of x-ray attenuation in different materials. PCXDs are especially suited for imaging Kedge contrast agents, re ... Full text Cite

A comparative analysis of EGFR-targeting antibodies for gold nanoparticle CT imaging of lung cancer.

Journal Article PLoS One · 2018 Computed tomography (CT) is the standard imaging test used for the screening and assessment of suspected lung cancer, but distinguishing malignant from benign nodules by CT is an ongoing challenge. Consequently, a large number of avoidable invasive procedu ... Full text Open Access Link to item Cite

A data-driven regularization strategy for statistical CT reconstruction

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2017 There is an unmet need for CT image reconstruction algorithms that reliably provide diagnostic image quality at reduced radiation dose. Toward this end, we integrate a state-of-the-art statistical reconstruction algorithm, ordered subsets, and separable qu ... Full text Cite

Localized and efficient cardiac CT reconstruction

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2017 The superiority of iterative reconstruction techniques over classic analytical ones is well documented in a variety of CT imaging applications where radiation dose and sampling time are limiting factors. However, by definition, the iterative nature of adva ... Full text Cite

Low-dose 4D myocardial perfusion with x-ray micro-CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2017 X-ray CT is widely used, both clinically and pre-clinically, for fast, high-resolution, anatomic imaging; however, compelling opportunities exist to expand its use in functional imaging applications. For instance, temporally-resolved CT data can detail car ... Full text Cite

Hybrid spectral CT reconstruction.

Journal Article PLoS One · 2017 Current photon counting x-ray detector (PCD) technology faces limitations associated with spectral fidelity and photon starvation. One strategy for addressing these limitations is to supplement PCD data with high-resolution, low-noise data acquired with an ... Full text Open Access Link to item Cite

A neural network-based method for spectral distortion correction in photon counting x-ray CT.

Journal Article Phys Med Biol · August 21, 2016 Spectral CT using a photon counting x-ray detector (PCXD) shows great potential for measuring material composition based on energy dependent x-ray attenuation. Spectral CT is especially suited for imaging with K-edge contrast agents to address the otherwis ... Full text Open Access Link to item Cite

A dual energy CT study on vascular effects of gold nanoparticles in radiation therapy

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2016 Gold nanoparticles (AuNPs) are emerging as promising agents for both cancer therapy and CT imaging. AuNPs are delivered to tumors via the enhanced permeability and retention effect and they preferentially accumulate in close proximity to the tumor blood ve ... Full text Cite

Resolution-enhancing hybrid, spectral CT reconstruction

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2016 Spectral x-ray imaging based on photon-counting x-ray detectors (PCXD) is an area of growing interest. By measuring the energy of x-ray photons, a spectral CT system can better differentiate elements using a single scan. However, the spatial resolution ach ... Full text Cite

Joint regularization for spectrooral CT reconstruction

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2016 X-ray CT is widely used, both clinically and preclinically, for fast, high-resolution, anatomic imaging; however, compelling opportunities exist to expand its use in functional imaging applications. For instance, spectral information combined with nanopart ... Full text Cite

Novel approaches to address spectral distortions in photon counting x-ray CT using artificial neural networks

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2016 Spectral CT using a photon-counting x-ray detector (PCXD) can potentially increase accuracy of measuring tissue composition. However, PCXD spectral measurements suffer from distortion due to charge sharing, pulse pileup, and Kescape energy loss. This study ... Full text Cite

Spectrotemporal CT data acquisition and reconstruction at low dose.

Journal Article Med Phys · November 2015 Featured Publication PURPOSE: X-ray computed tomography (CT) is widely used, both clinically and preclinically, for fast, high-resolution anatomic imaging; however, compelling opportunities exist to expand its use in functional imaging applications. For instance, spectral info ... Full text Open Access Link to item Cite

SU-C-303-07: Influence of Image Registration Algorithms and Noise Levels On the Accuracy of Fractional Regional Ventilation.

Journal Article Med Phys · June 2015 PURPOSE: The derivation of fractional regional lung-ventilation (FRV) involves registering images corresponding to extreme phases of the respiratory cycle. The purpose of this work was to investigate the influence of registration algorithms and image noise ... Full text Link to item Cite

Rank-sparsity constrained, spectro-temporal reconstruction for retrospectively gated, dynamic CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2015 Relative to prospective projection gating, retrospective projection gating for dynamic CT applications allows fast imaging times, minimizing the potential for physiological and anatomic variability. Preclinically, fast imaging is attractive due to the rapi ... Full text Cite

Spectral deblurring: An algorithm for high-resolution, hybrid spectral CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2015 We are developing a hybrid, dual-source micro-CT system based on the combined use of an energy integrating (EID) x-ray detector and a photon counting x-ray detector (PCXD). Due to their superior spectral resolving power, PCXDs have the potential to reduce ... Full text Cite

Simultaneous imaging of multiple contrast agents using full-spectrum micro-CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2015 One of the major challenges for in vivo, micro-computed tomography (CT) imaging is poor soft tissue contrast. To increase contrast, exogenous contrast agents can be used as imaging probes. Combining these probes with a photon counting x-ray detector (PCXD) ... Full text Cite

Rank-sparsity constrained atlas construction and phenotyping

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2015 Atlas construction is of great interest in the medical imaging community as a tool to visually and quantitatively characterize anatomic variability within a population. Because such atlases generally exhibit superior data fidelity relative to the individua ... Full text Cite

A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy.

Journal Article Theranostics · 2015 Nanomedicine has attracted increasing attention in recent years, because it offers great promise to provide personalized diagnostics and therapy with improved treatment efficacy and specificity. In this study, we developed a gold nanostar (GNS) probe for m ... Full text Open Access Link to item Cite

Localization of Metal Electrodes in the Intact Rat Brain Using Registration of 3D Microcomputed Tomography Images to a Magnetic Resonance Histology Atlas.

Journal Article eNeuro · 2015 Simultaneous neural recordings taken from multiple areas of the rodent brain are garnering growing interest due to the insight they can provide about spatially distributed neural circuitry. The promise of such recordings has inspired great progress in meth ... Full text Open Access Link to item Cite

In vivo small animal micro-CT using nanoparticle contrast agents.

Journal Article Front Pharmacol · 2015 Featured Publication Computed tomography (CT) is one of the most valuable modalities for in vivo imaging because it is fast, high-resolution, cost-effective, and non-invasive. Moreover, CT is heavily used not only in the clinic (for both diagnostics and treatment planning) but ... Full text Open Access Link to item Cite

Spectral diffusion: an algorithm for robust material decomposition of spectral CT data.

Journal Article Phys Med Biol · November 7, 2014 Clinical successes with dual energy CT, aggressive development of energy discriminating x-ray detectors, and novel, target-specific, nanoparticle contrast agents promise to establish spectral CT as a powerful functional imaging modality. Common to all of t ... Full text Open Access Link to item Cite

Micro-CT of rodents: state-of-the-art and future perspectives.

Journal Article Phys Med · September 2014 Featured Publication Micron-scale computed tomography (micro-CT) is an essential tool for phenotyping and for elucidating diseases and their therapies. This work is focused on preclinical micro-CT imaging, reviewing relevant principles, technologies, and applications. Commonly ... Full text Open Access Link to item Cite

Helical dual source cone-beam micro-CT

Conference 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014 · July 29, 2014 While helical scanning is well established in the clinical arena, most micro-CT scanners use circular cone beam trajectories and approximate reconstructions based on a filtered backprojection (FBP) algorithm. This may be sufficient for some applications, b ... Full text Cite

High-Resolution CT for Small-Animal Imaging Research

Chapter · July 25, 2014 Featured Publication Preclinical imaging has a critical role in phenotyping, in drug discovery, and in providing a basic understanding of mechanisms of disease. Translating imaging methods from humans to small animals is not an easy task. The purpose of this work is to review ... Full text Open Access Link to item Cite

Comparison of 4D-microSPECT and microCT for murine cardiac function.

Journal Article Mol Imaging Biol · April 2014 PURPOSE: The objective of this study was to compare a new generation of four-dimensional micro-single photon emission computed tomography (microSPECT) with microCT for the quantitative in vivo assessment of murine cardiac function. PROCEDURES: Four-dimensi ... Full text Link to item Cite

Assessing cardiac injury in mice with dual energy-microCT, 4D-microCT, and microSPECT imaging after partial heart irradiation.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2014 Featured Publication PURPOSE: To develop a mouse model of cardiac injury after partial heart irradiation (PHI) and to test whether dual energy (DE)-microCT and 4-dimensional (4D)-microCT can be used to assess cardiac injury after PHI to complement myocardial perfusion imaging ... Full text Open Access Link to item Cite

Dual-energy micro-CT functional imaging of primary lung cancer in mice using gold and iodine nanoparticle contrast agents: a validation study.

Journal Article PLoS One · 2014 Featured Publication PURPOSE: To provide additional functional information for tumor characterization, we investigated the use of dual-energy computed tomography for imaging murine lung tumors. Tumor blood volume and vascular permeability were quantified using gold and iodine ... Full text Open Access Link to item Cite

Anatomical and functional imaging of myocardial infarction in mice using micro-CT and eXIA 160 contrast agent.

Journal Article Contrast Media Mol Imaging · 2014 Featured Publication Noninvasive small animal imaging techniques are essential for evaluation of cardiac disease and potential therapeutics. A novel preclinical iodinated contrast agent called eXIA 160 has recently been developed, which has been evaluated for micro-CT cardiac ... Full text Link to item Cite

A multi-resolution approach to retrospectively-gated cardiac micro-CT reconstruction

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2014 In preclinical research, micro-CT is commonly used to provide anatomical information; however, there is significant interest in using this technology to obtain functional information in cardiac studies. The fastest acquisition in 4D cardiac micro-CT imagin ... Full text Cite

Robust material decomposition for spectral CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2014 There is ongoing interest in extending CT from anatomical to functional imaging. Recent successes with dual energy CT, the introduction of energy discriminating x-ray detectors, and novel, target-specific, nanoparticle contrast agents enable functional ima ... Full text Cite

Dual-energy micro-CT imaging of pulmonary airway obstruction: Correlation with micro-SPECT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2014 To match recent clinical dual energy (DE) CT studies focusing on the lung, similar developments for DE micro-CT of the rodent lung are required. Our group has been actively engaged in designing pulmonary gating techniques for micro- CT, and has also introd ... Full text Cite

Constructing a 4D murine cardiac micro-CT atlas for automated segmentation and phenotyping applications

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · June 3, 2013 A number of investigators have demonstrated the potential of preclinical micro-CT in characterizing cardiovascular disease in mouse models. One major hurdle to advancing this approach is the extensive user interaction required to derive quantitative metric ... Full text Cite

The effect of scatter correction on dual energy micro-CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · June 3, 2013 Dual energy (DE) CT imaging is expected to play a major role in the diagnostic arena as it provides a quantitative decomposition of basis materials, opening the door for new clinical applications without significantly increasing dose to the patient. DE-CT ... Full text Cite

WE-G-134-08: Extracting Fractional Regional Ventilation in Mice.

Journal Article Med Phys · June 2013 PURPOSE: Testing altered treatment paradigms, prospectively in cohorts of patients remains challenging due to the large variability in tumor characteristics and underlying comorbidities. Preclinical models of lung cancer can enable such studies in a contro ... Full text Link to item Cite

Dual-energy micro-computed tomography imaging of radiation-induced vascular changes in primary mouse sarcomas.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2013 Featured Publication PURPOSE: To evaluate the effects of radiation therapy on primary tumor vasculature using dual-energy (DE) micro-computed tomography (micro-CT). METHODS AND MATERIALS: Primary sarcomas were generated with mutant Kras and p53. Unirradiated tumors were compar ... Full text Link to item Cite

In vivo characterization of tumor vasculature using iodine and gold nanoparticles and dual energy micro-CT.

Journal Article Phys Med Biol · March 21, 2013 Featured Publication Tumor blood volume and vascular permeability are well established indicators of tumor angiogenesis and important predictors in cancer diagnosis, planning and treatment. In this work, we establish a novel preclinical imaging protocol which allows quantitati ... Full text Link to item Cite

Dual-energy computed tomography imaging of atherosclerotic plaques in a mouse model using a liposomal-iodine nanoparticle contrast agent.

Journal Article Circ Cardiovasc Imaging · March 1, 2013 BACKGROUND: The accumulation of macrophages in inflamed atherosclerotic plaques has long been recognized. In an attempt to develop an imaging agent for detection of vulnerable plaques, we evaluated the feasibility of a liposomal-iodine nanoparticle contras ... Full text Link to item Cite

A LabVIEW Platform for Preclinical Imaging Using Digital Subtraction Angiography and Micro-CT.

Journal Article J Med Eng · 2013 CT and digital subtraction angiography (DSA) are ubiquitous in the clinic. Their preclinical equivalents are valuable imaging methods for studying disease models and treatment. We have developed a dual source/detector X-ray imaging system that we have used ... Full text Open Access Link to item Cite

Assessing the radiation response of lung cancer with different gene mutations using genetically engineered mice.

Journal Article Front Oncol · 2013 PURPOSE: Non-small cell lung cancers (NSCLC) are a heterogeneous group of carcinomas harboring a variety of different gene mutations. We have utilized two distinct genetically engineered mouse models of human NSCLC (adenocarcinoma) to investigate how genet ... Full text Open Access Link to item Cite

Registration-based segmentation of murine 4D cardiac micro-CT data using symmetric normalization.

Journal Article Phys Med Biol · October 7, 2012 Featured Publication Micro-CT can play an important role in preclinical studies of cardiovascular disease because of its high spatial and temporal resolution. Quantitative analysis of 4D cardiac images requires segmentation of the cardiac chambers at each time point, an extrem ... Full text Link to item Cite

Temporal and spectral imaging with micro-CT.

Journal Article Med Phys · August 2012 Featured Publication PURPOSE: Micro-CT is widely used for small animal imaging in preclinical studies of cardiopulmonary disease, but further development is needed to improve spatial resolution, temporal resolution, and material contrast. We present a technique for visualizing ... Full text Link to item Cite

Dual-energy micro-CT of the rodent lung.

Journal Article Am J Physiol Lung Cell Mol Physiol · May 15, 2012 Featured Publication The purpose of this work is to investigate the use of dual-energy micro-computed tomography (CT) for the estimation of vascular, tissue, and air fractions in rodent lungs using a postreconstruction three material decomposition method. Using simulations, we ... Full text Link to item Cite

A spectral calibration technique for x-ray CT

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · May 4, 2012 Spectral reconstruction algorithms for x-ray CT require an accurate spectral model of the system, including the spectrum of the photons emitted by the source and the spectral sensitivity of the detector. Although these components of the spectral model have ... Full text Cite

A comparison of sampling strategies for dual energy micro-CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · May 4, 2012 Micro-CT has become a powerful tool for small animal research. Many micro-CT applications require exogenous contrast agents, which are most commonly based on iodine. Despite advancements in contrast agents, single-energy micro-CT is sometimes limited in th ... Full text Cite

Lung imaging in rodents using dual energy micro-CT.

Journal Article Proc SPIE Int Soc Opt Eng · April 3, 2012 Dual energy CT imaging is expected to play a major role in the diagnostic arena as it provides material decomposition on an elemental basis. The purpose of this work is to investigate the use of dual energy micro-CT for the estimation of vascular, tissue, ... Full text Link to item Cite

Denoising of 4D Cardiac Micro-CT Data Using Median-Centric Bilateral Filtration.

Conference Proc SPIE Int Soc Opt Eng · February 23, 2012 Featured Publication Bilateral filtration has proven an effective tool for denoising CT data. The classic filter utilizes Gaussian domain and range weighting functions in 2D. More recently, other distributions have yielded more accurate results in specific applications, and th ... Full text Link to item Cite

4D micro-CT using fast prospective gating.

Journal Article Phys Med Biol · January 7, 2012 Featured Publication Micro-CT is currently used in preclinical studies to provide anatomical information. But, there is also significant interest in using this technology to obtain functional information. We report here a new sampling strategy for 4D micro-CT for functional ca ... Full text Link to item Cite

Computed tomography imaging of primary lung cancer in mice using a liposomal-iodinated contrast agent.

Journal Article PLoS One · 2012 Featured Publication PURPOSE: To investigate the utility of a liposomal-iodinated nanoparticle contrast agent and computed tomography (CT) imaging for characterization of primary nodules in genetically engineered mouse models of non-small cell lung cancer. METHODS: Primary lun ... Full text Open Access Link to item Cite

Investigations on X-ray luminescence CT for small animal imaging.

Conference Proc SPIE Int Soc Opt Eng · 2012 Featured Publication X-ray Luminescence CT (XLCT) is a hybrid imaging modality combining x-ray and optical imaging in which x-ray luminescent nanophosphors (NPs) are used as emissive imaging probes. NPs are easily excited using common CT energy x-ray beams, and the NP luminesc ... Full text Link to item Cite

Data analysis: evaluation of nanoscale contrast agent enhanced CT scan to differentiate between benign and malignant lung cancer in mouse model.

Journal Article AMIA Annu Symp Proc · 2012 Proposed is a method for statistical analysis for a small sample size, repeated measure experiment with nesting factors. In the original experiment the Student t-test was used for analysis. Using the same data, we modeled the experiment into two groups of ... Link to item Cite

High-resolution reconstruction of fluorescent inclusions in mouse thorax using anatomically guided sampling and parallel Monte Carlo computing.

Journal Article Biomed Opt Express · September 1, 2011 Featured Publication We present a method for high-resolution reconstruction of fluorescent images of the mouse thorax. It features an anatomically guided sampling method to retrospectively eliminate problematic data and a parallel Monte Carlo software package to compute the Ja ... Full text Open Access Link to item Cite

4D micro-CT for cardiac and perfusion applications with view under sampling.

Journal Article Phys Med Biol · June 7, 2011 Featured Publication Micro-CT is commonly used in preclinical studies to provide anatomical information. There is growing interest in obtaining functional measurements from 4D micro-CT. We report here strategies for 4D micro-CT with a focus on two applications: (i) cardiac ima ... Full text Link to item Cite

Multi-modality PET-CT imaging of breast cancer in an animal model using nanoparticle x-ray contrast agent and 18F-FDG

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · May 16, 2011 Multi-modality PET-CT imaging is playing an important role in the field of oncology. While PET imaging facilitates functional interrogation of tumor status, the use of CT imaging is primarily limited to anatomical reference. In an attempt to extract compre ... Full text Cite

Dual-energy micro-CT imaging for differentiation of iodine- and gold-based nanoparticles

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · May 13, 2011 Spectral CT imaging is expected to play a major role in the diagnostic arena as it provides material decomposition on an elemental basis. One fascinating possibility is the ability to discriminate multiple contrast agents targeting different biological sit ... Full text Cite

Temporal and spectral reconstruction algorithms for x-ray CT

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · May 13, 2011 X-ray CT imaging of dynamic physiological processes entails the reconstruction of volumetric images of objects with x-ray attenuation properties that vary over time and energy. We show how the same algebraic model can be used to represent both temporal and ... Full text Cite

Highly efficient detection in fluorescence tomography of quantum dots using time-gated acquisition and ultrafast pulsed laser.

Journal Article Proc SPIE Int Soc Opt Eng · January 23, 2011 Quantum dots (QDs) are widely used in fluorescence tomography due to its unique advantages. Despite the very high quantum efficiency of the QDs, low fluorescent signal and autofluorescence are the most fundamental limitations in optical data acquisition. T ... Full text Open Access Link to item Cite

Evaluation of tumor microenvironment in an animal model using a nanoparticle contrast agent in computed tomography imaging.

Journal Article Acad Radiol · January 2011 Featured Publication RATIONALE AND OBJECTIVES: Non-invasive longitudinal imaging of tumor vasculature could provide new insights into the development of solid tumors, facilitating efficient delivery of therapeutics. In this study, we report three-dimensional imaging and charac ... Full text Link to item Cite

Phenylephrine-modulated cardiopulmonary blood flow measured with use of X-ray digital subtraction angiography.

Journal Article J Pharmacol Toxicol Methods · 2011 Featured Publication INTRODUCTION: Cardiopulmonary blood flow is an important indicator of organ function. Limitations in measuring blood flow in live rodents suggest that rapid physiological changes may be overlooked. For instance, relative measurements limit imaging to whole ... Full text Link to item Cite

In vivo imaging of rat coronary arteries using bi-plane digital subtraction angiography.

Journal Article J Pharmacol Toxicol Methods · 2011 Featured Publication INTRODUCTION: X-ray based digital subtraction angiography (DSA) is a common clinical imaging method for vascular morphology and function. Coronary artery characterization is one of its most important applications. We show that bi-plane DSA of rat coronary ... Full text Link to item Cite

Micro-CT imaging assessment of dobutamine-induced cardiac stress in rats.

Journal Article J Pharmacol Toxicol Methods · 2011 Featured Publication INTRODUCTION: Dobutamine (DOB) stress in animal models of heart disease has been imaged so far using echocardiography and magnetic resonance imaging. The purpose of this study was to assess normal response to DOB stress in rats using anatomical and functio ... Full text Link to item Cite

Application of artificial neural networks to a study of nursing burnout.

Journal Article Ergonomics · September 2010 Nursing is generally considered to be a profession with high levels of emotional and physical stress that tend to increase. These high stress levels lead to a high risk of burnout. The objective was to assess whether artificial neural network (ANN) paradig ... Full text Link to item Cite

Phase-selective image reconstruction of the lungs in small animals using Micro-CT.

Journal Article Proc SPIE Int Soc Opt Eng · February 15, 2010 Featured Publication Gating in small animal imaging can compensate for artifacts due to physiological motion. This paper presents a strategy for sampling and image reconstruction in the rodent lung using micro-CT. The approach involves rapid sampling of free-breathing mice wit ... Full text Link to item Cite

GPU-based iterative reconstruction with total variation minimization for micro-CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · 2010 Dynamic imaging with micro-CT often produces poorly-distributed sets of projections, and reconstructions of this data with filtered backprojection algorithms (FBP) may be affected by artifacts. Iterative reconstruction algorithms and total variation (TV) d ... Full text Cite

Free-space fluorescence tomography with adaptive sampling based on anatomical information from microCT.

Conference Proc SPIE Int Soc Opt Eng · 2010 Featured Publication Image reconstruction is one of the main challenges for fluorescence tomography. For in vivo experiments on small animals, in particular, the inhomogeneous optical properties and irregular surface of the animal make free-space image reconstruction challengi ... Full text Link to item Cite

Lung perfusion imaging in small animals using 4D micro-CT at heartbeat temporal resolution.

Journal Article Med Phys · January 2010 Featured Publication PURPOSE: Quantitative in vivo imaging of lung perfusion in rodents can provide critical information for preclinical studies. However, the combined challenges of high temporal and spatial resolution have made routine quantitative perfusion imaging difficult ... Full text Link to item Cite

Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent

Journal Article International Journal of Nanomedicine · November 2009 Full text Cite

Quantitative blood flow measurements in the small animal cardiopulmonary system using digital subtraction angiography.

Journal Article Med Phys · November 2009 Featured Publication PURPOSE: The use of preclinical rodent models of disease continues to grow because these models help elucidate pathogenic mechanisms and provide robust test beds for drug development. Among the major anatomic and physiologic indicators of disease progressi ... Full text Link to item Cite

Dissecting the Mechanism of Tumor Response to Radiation Therapy with Primary Lung Cancers in Mice

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

In Vivo shRNA to Study the Molecular Mechanisms of Radiation Response of Primary Cancers in Mice

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

ZINC SULFIDE FINE PARTICLES OBTAINED AT LOW TEMPERATURE

Journal Article CHALCOGENIDE LETTERS · September 1, 2009 Link to item Cite

A material decomposition method for dual energy micro-CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · June 15, 2009 The attenuation of x-rays in matter is dependent on the energy of the x-rays and the atomic composition of the matter. Attenuation measurements at multiple x-ray energies can be used to improve the identification of materials. We present a method to estima ... Full text Cite

4D micro-CT-based perfusion imaging in small animals

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · June 15, 2009 Quantitative in-vivo imaging of lung perfusion in rodents can provide critical information for preclinical studies. However, the combined challenges of high temporal and spatial resolution have made routine quantitative perfusion imaging difficult in roden ... Full text Cite

Effects of sampling strategy on image quality in noncontact panoramic fluorescence diffuse optical tomography for small animal imaging.

Journal Article Opt Express · March 30, 2009 Featured Publication Fluorescence diffuse optical tomography is an emerging technology for molecular imaging with recent technological advances in biomarkers and photonics. The introduction of noncontact imaging methods enables very large-scale data acquisition that is orders ... Full text Link to item Cite

Development of a noncontact 3-D fluorescence tomography system for small animal in vivo imaging.

Conference Proc SPIE Int Soc Opt Eng · February 16, 2009 Featured Publication Fluorescence imaging is an important tool for tracking molecular-targeting probes in preclinical studies. It offers high sensitivity, but nonetheless low spatial resolution compared to other leading imaging methods such CT and MRI. We demonstrate our metho ... Full text Link to item Cite

Three-dimensional reconstruction in free-space whole-body fluorescence tomography of mice using optically reconstructed surface and atlas anatomy.

Journal Article J Biomed Opt · 2009 We present a 3-D image reconstruction method for free-space fluorescence tomography of mice using hybrid anatomical prior information. Specifically, we use an optically reconstructed surface of the experimental animal and a digital mouse atlas to approxima ... Full text Link to item Cite

Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent.

Journal Article Int J Nanomedicine · 2009 Featured Publication A long circulating liposomal, nanoscale blood pool agent encapsulating traditional iodinated contrast agent (65 mg I/mL) was used for micro-computed tomography (CT) imaging of rats implanted with R3230AC mammary carcinoma. Three-dimensional vascular archit ... Open Access Link to item Cite

Dye-sensitized solar cells based on nanocrystalline TiO2 and natural pigments

Conference JOURNAL OF OPTOELECTRONICS AND ADVANCED MATERIALS · November 1, 2008 Link to item Cite

In vivo small-animal imaging using micro-CT and digital subtraction angiography.

Journal Article Phys Med Biol · October 7, 2008 Small-animal imaging has a critical role in phenotyping, drug discovery and in providing a basic understanding of mechanisms of disease. Translating imaging methods from humans to small animals is not an easy task. The purpose of this work is to review in ... Full text Link to item Cite

A micro-CT analysis of murine lung recruitment in bleomycin-induced lung injury.

Journal Article J Appl Physiol (1985) · August 2008 The effects of lung injury on pulmonary recruitment are incompletely understood. X-ray computed tomography (CT) has been a valuable tool in assessing changes in recruitment during lung injury. With the development of preclinical CT scanners designed for th ... Full text Link to item Cite

Utility of a prototype liposomal contrast agent for x-ray imaging of breast cancer: A proof of concept using micro-CT in small animals

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · May 14, 2008 Imaging tumor angiogenesis in small animals is extremely challenging due to the size of the tumor vessels. Consequently, both dedicated small animal imaging systems and specialized intravascular contrast agents are required. The goal of this study was to i ... Full text Cite

Optimization of dual energy contrast enhanced breast tomosynthesis for improved mammographic lesion detection and diagnosis

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · May 14, 2008 Dual-energy contrast-enhanced breast tomosynthesis has been proposed as a technique to improve the detection of early-stage cancer in young, high-risk women. This study focused on optimizing this technique using computer simulations. The computer simulatio ... Full text Cite

Geometric calibration for a dual tube/detector micro-CT system.

Journal Article Med Phys · May 2008 The authors describe a dual tube/detector micro-computed tomography (micro-CT) system that has the potential to improve temporal resolution and material contrast in small animal imaging studies. To realize this potential, it is necessary to precisely calib ... Full text Link to item Cite

A dual micro-CT system for small animal imaging.

Conference Proc SPIE Int Soc Opt Eng · April 18, 2008 Featured Publication Micro-CT is a non-invasive imaging modality usually used to assess morphology in small animals. In our previous work, we have demonstrated that functional micro-CT imaging is also possible. This paper describes a dual micro-CT system with two fixed x-ray/d ... Full text Link to item Cite

Left ventricle volume measurements in cardiac micro-CT: the impact of radiation dose and contrast agent.

Journal Article Comput Med Imaging Graph · April 2008 Micro-CT-based cardiac function estimation in small animals requires measurement of left ventricle (LV) volume at multiple time points during the cardiac cycle. Measurement accuracy depends on the image resolution, its signal and noise properties, and the ... Full text Link to item Cite

A registration based approach for 4D cardiac micro-CT using combined prospective and retrospective gating.

Journal Article Med Phys · April 2008 Recent advances in murine cardiac studies with three-dimensional cone beam micro-computed tomography (CT) have used either prospective or retrospective gating technique. While prospective gating ensures the best image quality and the highest resolution, it ... Full text Link to item Cite

A high-precision contrast injector for small animal x-ray digital subtraction angiography.

Journal Article IEEE Trans Biomed Eng · March 2008 Featured Publication The availability of genetically altered animal models of human disease for basic research has generated great interest in new imaging methodologies. Digital subtraction angiography (DSA) offers an appealing approach to functional imaging in small animals b ... Full text Link to item Cite

TH‐C‐351‐02: Registration Based Automatic Segmentation and Wall Motion Analysis for 4D Cardiac Micro‐CT in Mice

Conference Medical Physics · January 1, 2008 Purpose: We present an automated method for segmentation and tracking of hearth anatomy using 4D cardiac micro‐CT datasets in mice. Cardiac motion is determined and analyzed using the deformation field obtained after non‐rigidly deforming a template to all ... Full text Cite

Sparseness prior based iterative image reconstruction for retrospectively gated cardiac micro-CT.

Journal Article Med Phys · November 2007 Featured Publication Recent advances in murine cardiac studies with three-dimensional (3D) cone beam micro-CT used a retrospective gating technique. However, this sampling technique results in a limited number of projections with an irregular angular distribution due to the te ... Full text Link to item Cite

High-resolution imaging of murine myocardial infarction with delayed-enhancement cine micro-CT.

Journal Article Am J Physiol Heart Circ Physiol · June 2007 Featured Publication The objective of this study was to determine the feasibility of delayed-enhancement micro-computed tomography (microCT) imaging to quantify myocardial infarct size in experimental mouse models. A total of 20 mice were imaged 5 or 35 days after surgical lig ... Full text Link to item Cite

Tomographic digital subtraction angiography for lung perfusion estimation in rodents.

Journal Article Med Phys · May 2007 Featured Publication In vivo measurements of perfusion present a challenge to existing small animal imaging techniques such as magnetic resonance microscopy, micro computed tomography, micro positron emission tomography, and microSPECT, due to combined requirements for high sp ... Full text Link to item Cite

A micro-computed tomography-based method for the measurement of pulmonary compliance in healthy and bleomycin-exposed mice.

Journal Article Exp Lung Res · 2007 Micro-computed tomography (microCT) is being increasingly used to examine small animal models of pulmonary injury. The authors have developed a microCT technique suitable for the determination of pulmonary compliance in injured mice. Lung volumes in normal ... Full text Link to item Cite

Cardiac micro-computed tomography for morphological and functional phenotyping of muscle LIM protein null mice.

Journal Article Mol Imaging · 2007 The purpose of this study was to investigate the use of micro-computed tomography (micro-CT) for morphological and functional phenotyping of muscle LIM protein (MLP) null mice and to compare micro-CT with M-mode echocardiography. MLP null mice and controls ... Link to item Cite

Measurement and modeling of 4D live mouse heart volumes from CT time series

Conference Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2007 In vivo quantitative studies of cardiac function in mouse models provide information about cardiac pathophysiology in more detail than can be obtained in humans. Quantitative measurements of left ventricular (LV) volume at multiple contractile phases are p ... Full text Cite

Functional imaging in small animals using tomographic digital subtraction angiography

Conference 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings · November 17, 2006 We propose the use of Tomographic Digital Subtraction Angiography (TDSA) for functional imaging in small animals. TDSA combines the advantages of high temporal resolution of digital subtraction angiography (DSA) and high spatial resolution of micro-compute ... Cite

Optimized radiographic spectra for small animal digital subtraction angiography.

Journal Article Med Phys · November 2006 Featured Publication The increasing use of small animals in basic research has spurred interest in new imaging methodologies. Digital subtraction angiography (DSA) offers a particularly appealing approach to functional imaging in the small animal. This study examines the optim ... Full text Link to item Cite

Three-dimensional imaging of xenograft tumors using optical computed and emission tomography.

Journal Article Med Phys · September 2006 Featured Publication The physical basis and preliminary applications of optical computed tomography (optical-CT) and optical emission computed tomography (optical-ECT) are introduced, as new techniques with potential to provide unique 3D information on a variety of aspects of ... Full text Link to item Cite

A liposomal nanoscale contrast agent for preclinical CT in mice.

Journal Article AJR Am J Roentgenol · February 2006 Featured Publication OBJECTIVE: The goal of this study was to determine if an iodinated, liposomal contrast agent could be used for high-resolution, micro-CT of low-contrast, small-size vessels in a murine model. MATERIALS AND METHODS: A second-generation, liposomal blood pool ... Full text Link to item Cite

Tumor imaging in small animals with a combined micro-CT/micro-DSA system using iodinated conventional and blood pool contrast agents.

Journal Article Contrast Media Mol Imaging · 2006 Featured Publication X-ray based micro-computed tomography (CT) and micro-digital subtraction angiography (DSA) are important non-invasive imaging modalities for following tumorogenesis in small animals. To exploit these imaging capabilities further, the two modalities were co ... Full text Link to item Cite

Imaging methods for morphological and functional phenotyping of the rodent heart.

Journal Article Toxicol Pathol · 2006 Featured Publication Small animal imaging has a critical role in phenotyping, drug discovery, and in providing a basic understanding of mechanisms of disease. Translating imaging methods from humans to small animals is not an easy task. The purpose of this work is to compare t ... Full text Link to item Cite

Development and evaluation of an ODL course on Medical Image Processing.

Journal Article Med Eng Phys · September 2005 Recent developments in the field of Biomedical Engineering have led to considerable improvement in health care delivery, but also impose continuous change and improvement in education and training schemes of its professionals, in order to assure appropriat ... Full text Link to item Cite

Effects of breathing and cardiac motion on spatial resolution in the microscopic imaging of rodents.

Journal Article Magn Reson Med · April 2005 Featured Publication One can acquire high-resolution pulmonary and cardiac images in live rodents with MR microscopy by synchronizing the image acquisition to the breathing cycle across multiple breaths, and gating to the cardiac cycle. The precision with which one can synchro ... Full text Link to item Cite

4-D micro-CT of the mouse heart.

Journal Article Mol Imaging · 2005 Featured Publication PURPOSE: Demonstrate noninvasive imaging methods for in vivo characterization of cardiac structure and function in mice using a micro-CT system that provides high photon fluence rate and integrated motion control. MATERIALS AND METHODS: Simultaneous cardia ... Full text Link to item Cite

Micro-CT with respiratory and cardiac gating.

Journal Article Med Phys · December 2004 Featured Publication Cardiopulmonary imaging in rodents using micro-computed tomography (CT) is a challenging task due to both cardiac and pulmonary motion and the limited fluence rate available from micro-focus x-ray tubes of most commercial systems. Successful imaging in the ... Full text Link to item Cite

Optimized radiographic spectra for digital subtraction angiography in the mouse

Conference 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano · December 1, 2004 The availability of genetically altered mouse models of human disease and the increasing use of small animals in basic research have spurred extraordinary interest in new imaging methodologies - particularly magnetic resonance microscopy, microCT, and micr ... Cite

Volumetric micro-CT system for in vivo microscopy

Conference 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano · December 1, 2004 Two of the major barriers to improved image quality in micro-CT are the reduced signal to noise imposed by the smaller voxels and the effects of physiologic motion. The most direct approach to increase the signal to noise ratio (SNR) is to increase the flu ... Cite

Effects of breathing motion on the spatial resolution in microscopic imaging techniques of rodents

Conference 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano · December 1, 2004 Magnetic resonance microscopy is capable of producing high-resolution pulmonary images in live rodents by synchronizing the image acquisition across multiple breaths. The precision with which one can control motion will probably define the resolution limit ... Cite

Experiments with the nonlinear and chaotic behaviour of the multiplicative algebraic reconstruction technique (MART) algorithm for computed tomography.

Journal Article Phys Med Biol · April 21, 2004 Featured Publication Among the iterative reconstruction algorithms for tomography, the multiplicative algebraic reconstruction technique (MART) has two advantages that make it stand out from other algorithms: it confines the image (and therefore the projection data) to the con ... Full text Link to item Cite

Development and evaluation of an ODL course on medical image processing

Conference Proceedings of the IASTED International Conference on Web-Based Education · 2004 Cite

Estimation of the heart respiratory motion with applications for cone beam computed tomography imaging: a simulation study.

Journal Article IEEE Trans Inf Technol Biomed · December 2003 Featured Publication Computed tomography (CT) reconstruction methods assume imaging of static objects; object movement during projection data acquisition causes tomogram artifacts. The continuously moving heart, therefore, represents a complicated imaging case. The associated ... Full text Link to item Cite

A novel approach for distortion correction for X-ray image intensifiers.

Journal Article Comput Med Imaging Graph · 2003 Featured Publication Applications of X-ray image intensifiers in medical imaging, include the use of fluoroscopic projection images to generate three-dimensional tomographic reconstructions. Unfortunately, the inherent distortions on the acquired projections deteriorate the qu ... Full text Link to item Cite

Respiratory displacement modelling in cone beam computed tomography

Journal Article Computers in Cardiology · January 1, 2003 Any organ motion during the projection acquisition causes blurring artefacts in the Computed Tomography (CT) reconstructions. It is a drawback in applications of Cone Beam CT (CBCT) for which, the complete scanning cannot be performed during a single breat ... Full text Cite

Logarithmic amplifier for computed tomography tasks using fluoroscopic projections.

Journal Article J Med Eng Technol · 2002 Featured Publication The image intensifier (II)-based imaging systems, as radiotherapy simulators or C-arm X-ray units, have also been used for image acquisition in computed tomography. When analogue-to-digital conversion is performed on the output signal of the television cam ... Full text Link to item Cite

Image quality in extended arc filtered digital tomosynthesis.

Journal Article Acta Radiol · March 2001 Featured Publication PURPOSE: To study image quality in filtered digital tomosynthesis (FDTS) tomograms as a function of their reconstruction arc, using isocentrically acquired, fluoroscopic projection data. MATERIAL AND METHODS: Both digital tomosynthesis (DTS) and cone beam ... Full text Link to item Cite

A 3-D imaging system for in-theatre orthopedic applications based on Digital Tomosynthesis

Conference CARS 2001: COMPUTER ASSISTED RADIOLOGY AND SURGERY · January 1, 2001 Link to item Cite

A 3D imaging system for dental imaging based on digital tomosynthesis and cone beam CT

Conference MEDICON 2001: PROCEEDINGS OF THE INTERNATIONAL FEDERATION FOR MEDICAL & BIOLOGICAL ENGINEERING, PTS 1 AND 2 · January 1, 2001 Link to item Cite

Cone based 3D reconstruction: A FDK-SART comparison for limited number of projections

Conference MEDICON 2001: PROCEEDINGS OF THE INTERNATIONAL FEDERATION FOR MEDICAL & BIOLOGICAL ENGINEERING, PTS 1 AND 2 · January 1, 2001 Link to item Cite

Three-dimensional localisation based on projectional and tomographic image correlation: an application for digital tomosynthesis.

Journal Article Med Eng Phys · March 1999 Featured Publication Accurate three-dimensional tumor localisation in Radiotherapy, is critical to the treatment outcome, particularly when high dose gradients are present. A number of techniques have been proposed for the localisation of anatomical structures or markers. The ... Full text Link to item Cite

A software tool to assist the planning of electrophysiological experiments on rat brain slices

Journal Article Studies in Health Technology and Informatics · January 1, 1999 We propose an interactive software tool for finding the plane which can be cut through the rat brain so as to contain maximum cross-section with a selected brain structure or combination of structures, i.e. a path of nerve fibers and the area they are know ... Full text Cite

A wavelet-based method for removal of out-of-plane structures in digital tomosynthesis.

Journal Article Comput Med Imaging Graph · 1998 Featured Publication Reconstructed images in digital tomosynthesis (DTS) are affected by artifacts due to blur from planes other than the fulcrum plane. A wavelet-based method has been developed for the discrimination and subsequent removal of unrelated structures from the rec ... Full text Link to item Cite

427A localization tool on the basis of digital tomosynthesis

Journal Article Radiotherapy and Oncology · January 1996 Full text Cite

Medical device surveillance world-wide.

Journal Article Stud Health Technol Inform · 1996 Featured Publication Link to item Cite