Scholars@Duke publication: A micro-computed tomography-based method for the measurement of pulmonary compliance in healthy and bleomycin-exposed mice.

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A micro-computed tomography-based method for the measurement of pulmonary compliance in healthy and bleomycin-exposed mice.

Publication , Journal Article

Shofer, S; Badea, C; Auerbach, S; Schwartz, DA; Johnson, GA

Published in: Exp Lung Res

2007

Published version (DOI) Link to item

Micro-computed tomography (microCT) is being increasingly used to examine small animal models of pulmonary injury. The authors have developed a microCT technique suitable for the determination of pulmonary compliance in injured mice. Lung volumes in normal mice were radiographically determined at end-inspiration and end-expiration and pulmonary compliance was calculated at 2 time points 2 weeks apart, whereas a second group of mice were given bleomycin and imaged 3 weeks following drug administration. Compliance measurements were validated using a commercially available ventilator system. MicroCT pulmonary compliance measurements are suitable for longitudinal measurements, and correlate with physiologic measurements of pulmonary compliance.

Duke Scholars

Author Scott Leigh Shofer Medicine, Pulmonary, Allergy, and Critical Care Medicine

Author Cristian Tudorel Badea Radiology

Author G. Allan Johnson Radiology

Published In

Exp Lung Res

DOI

10.1080/01902140701364458

ISSN

0190-2148

Publication Date

2007

Volume

33

Issue

3-4

Start / End Page

169 / 183

Location

England

Related Subject Headings

Tomography, X-Ray Computed
Time Factors
Respiratory System
Reproducibility of Results
Pulmonary Fibrosis
Mice, Inbred C57BL
Mice
Male
Lung Compliance
Lung

Citation

APA

Chicago

ICMJE

MLA

NLM

Shofer, S., Badea, C., Auerbach, S., Schwartz, D. A., & Johnson, G. A. (2007). A micro-computed tomography-based method for the measurement of pulmonary compliance in healthy and bleomycin-exposed mice. Exp Lung Res, 33(3–4), 169–183. https://doi.org/10.1080/01902140701364458

Shofer, Scott, Cristian Badea, Scott Auerbach, David A. Schwartz, and G Allan Johnson. “A micro-computed tomography-based method for the measurement of pulmonary compliance in healthy and bleomycin-exposed mice.” Exp Lung Res 33, no. 3–4 (2007): 169–83. https://doi.org/10.1080/01902140701364458.

Shofer S, Badea C, Auerbach S, Schwartz DA, Johnson GA. A micro-computed tomography-based method for the measurement of pulmonary compliance in healthy and bleomycin-exposed mice. Exp Lung Res. 2007;33(3–4):169–83.

Shofer, Scott, et al. “A micro-computed tomography-based method for the measurement of pulmonary compliance in healthy and bleomycin-exposed mice.” Exp Lung Res, vol. 33, no. 3–4, 2007, pp. 169–83. Pubmed, doi:10.1080/01902140701364458.

Shofer S, Badea C, Auerbach S, Schwartz DA, Johnson GA. A micro-computed tomography-based method for the measurement of pulmonary compliance in healthy and bleomycin-exposed mice. Exp Lung Res. 2007;33(3–4):169–183.

Journal cover image

Published In

Exp Lung Res

DOI

10.1080/01902140701364458

ISSN

0190-2148

Publication Date

2007

Volume

33

Issue

3-4

Start / End Page

169 / 183

Location

England

Related Subject Headings

Tomography, X-Ray Computed
Time Factors
Respiratory System
Reproducibility of Results
Pulmonary Fibrosis
Mice, Inbred C57BL
Mice
Male
Lung Compliance
Lung