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In vivo small-animal imaging using micro-CT and digital subtraction angiography.

Publication ,  Journal Article
Badea, CT; Drangova, M; Holdsworth, DW; Johnson, GA
Published in: Phys Med Biol
October 7, 2008

Small-animal imaging has a critical role in phenotyping, drug discovery and in providing a basic understanding of mechanisms of disease. Translating imaging methods from humans to small animals is not an easy task. The purpose of this work is to review in vivo x-ray based small-animal imaging, with a focus on in vivo micro-computed tomography (micro-CT) and digital subtraction angiography (DSA). We present the principles, technologies, image quality parameters and types of applications. We show that both methods can be used not only to provide morphological, but also functional information, such as cardiac function estimation or perfusion. Compared to other modalities, x-ray based imaging is usually regarded as being able to provide higher throughput at lower cost and adequate resolution. The limitations are usually associated with the relatively poor contrast mechanisms and potential radiation damage due to ionizing radiation, although the use of contrast agents and careful design of studies can address these limitations. We hope that the information will effectively address how x-ray based imaging can be exploited for successful in vivo preclinical imaging.

Duke Scholars

Published In

Phys Med Biol

DOI

ISSN

0031-9155

Publication Date

October 7, 2008

Volume

53

Issue

19

Start / End Page

R319 / R350

Location

England

Related Subject Headings

  • X-Ray Microtomography
  • Nuclear Medicine & Medical Imaging
  • Humans
  • Animals
  • Angiography, Digital Subtraction
  • 5105 Medical and biological physics
  • 1103 Clinical Sciences
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Badea, C. T., Drangova, M., Holdsworth, D. W., & Johnson, G. A. (2008). In vivo small-animal imaging using micro-CT and digital subtraction angiography. Phys Med Biol, 53(19), R319–R350. https://doi.org/10.1088/0031-9155/53/19/R01
Badea, C. T., M. Drangova, D. W. Holdsworth, and G. A. Johnson. “In vivo small-animal imaging using micro-CT and digital subtraction angiography.Phys Med Biol 53, no. 19 (October 7, 2008): R319–50. https://doi.org/10.1088/0031-9155/53/19/R01.
Badea CT, Drangova M, Holdsworth DW, Johnson GA. In vivo small-animal imaging using micro-CT and digital subtraction angiography. Phys Med Biol. 2008 Oct 7;53(19):R319–50.
Badea, C. T., et al. “In vivo small-animal imaging using micro-CT and digital subtraction angiography.Phys Med Biol, vol. 53, no. 19, Oct. 2008, pp. R319–50. Pubmed, doi:10.1088/0031-9155/53/19/R01.
Badea CT, Drangova M, Holdsworth DW, Johnson GA. In vivo small-animal imaging using micro-CT and digital subtraction angiography. Phys Med Biol. 2008 Oct 7;53(19):R319–R350.
Journal cover image

Published In

Phys Med Biol

DOI

ISSN

0031-9155

Publication Date

October 7, 2008

Volume

53

Issue

19

Start / End Page

R319 / R350

Location

England

Related Subject Headings

  • X-Ray Microtomography
  • Nuclear Medicine & Medical Imaging
  • Humans
  • Animals
  • Angiography, Digital Subtraction
  • 5105 Medical and biological physics
  • 1103 Clinical Sciences
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences