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Investigations on X-ray luminescence CT for small animal imaging.

Publication ,  Conference
Badea, CT; Stanton, IN; Johnston, SM; Johnson, GA; Therien, MJ
Published in: Proc SPIE Int Soc Opt Eng
2012

X-ray Luminescence CT (XLCT) is a hybrid imaging modality combining x-ray and optical imaging in which x-ray luminescent nanophosphors (NPs) are used as emissive imaging probes. NPs are easily excited using common CT energy x-ray beams, and the NP luminescence is efficiently collected using sensitive light based detection systems. XLCT can be recognized as a close analog to fluorescence diffuse optical tomography (FDOT). However, XLCT has remarkable advantages over FDOT due to the substantial excitation penetration depths provided by x-rays relative to laser light sources, long term photo-stability of NPs, and the ability to tune NP emission within the NIR spectral window. Since XCLT uses an x-ray pencil beam excitation, the emitted light can be measured and back-projected along the x-ray path during reconstruction, where the size of the X-ray pencil beam determines the resolution for XLCT. In addition, no background signal competes with NP luminescence (i.e., no auto fluorescence) in XLCT. Currently, no small animal XLCT system has been proposed or tested. This paper investigates an XLCT system built and integrated with a dual source micro-CT system. Two novel sampling paradigms that result in more efficient scanning are proposed and tested via simulations. Our preliminary experimental results in phantoms indicate that a basic CT-like reconstruction is able to recover a map of the NP locations and differences in NP concentrations. With the proposed dual source system and faster scanning approaches, XLCT has the potential to revolutionize molecular imaging in preclinical studies.

Duke Scholars

Published In

Proc SPIE Int Soc Opt Eng

DOI

ISSN

0277-786X

Publication Date

2012

Volume

8313

Start / End Page

83130T

Location

United States

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering
 

Citation

APA
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ICMJE
MLA
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Badea, C. T., Stanton, I. N., Johnston, S. M., Johnson, G. A., & Therien, M. J. (2012). Investigations on X-ray luminescence CT for small animal imaging. In Proc SPIE Int Soc Opt Eng (Vol. 8313, p. 83130T). United States. https://doi.org/10.1117/12.911465
Badea, C. T., I. N. Stanton, S. M. Johnston, G. A. Johnson, and M. J. Therien. “Investigations on X-ray luminescence CT for small animal imaging.” In Proc SPIE Int Soc Opt Eng, 8313:83130T, 2012. https://doi.org/10.1117/12.911465.
Badea CT, Stanton IN, Johnston SM, Johnson GA, Therien MJ. Investigations on X-ray luminescence CT for small animal imaging. In: Proc SPIE Int Soc Opt Eng. 2012. p. 83130T.
Badea, C. T., et al. “Investigations on X-ray luminescence CT for small animal imaging.Proc SPIE Int Soc Opt Eng, vol. 8313, 2012, p. 83130T. Pubmed, doi:10.1117/12.911465.
Badea CT, Stanton IN, Johnston SM, Johnson GA, Therien MJ. Investigations on X-ray luminescence CT for small animal imaging. Proc SPIE Int Soc Opt Eng. 2012. p. 83130T.

Published In

Proc SPIE Int Soc Opt Eng

DOI

ISSN

0277-786X

Publication Date

2012

Volume

8313

Start / End Page

83130T

Location

United States

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering