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Co-clinical photon counting CT research for multi-contrast imaging

Publication ,  Conference
Badea, CT; Clark, DP; Alphin, A; Ramirez-Giraldo, JC; Bhandari, P; Mowery, YM; Ghaghada, KB
Published in: Proceedings of SPIE - The International Society for Optical Engineering
January 1, 2022

Developing novel contrast agents for multi-energy photon-counting (PC)CT will require a clear translation pathway from preclinical validation to clinical applications. To begin this development, we have used a clinical PCCT scanner (Siemens NAEOTOM Alpha) to study the spectral separation of a few contrast elements (Iodine, I; Gadolinium, Gd; Hafnium, Hf; Tantalum, Ta; Bismuth, Bi; Calcium, Ca) with currently available scanning protocols (fixed: 120 kVp, 20 and 65 keV thresholds). We also explored the capabilities of clinical and preclinical PCCT to image mice with sarcoma tumors injected with nanoparticles (NP). Our results indicate that Ta or Hf are complementary to I or Gd, providing excellent spectral separation for future multi-agent studies. Based on preclinical PCCT with four energy thresholds, we also conclude that additional energy thresholds will benefit clinical PCCT. Furthermore, we demonstrate the role that multi-channel denoising and reconstruction algorithms will play in pushing the bounds of spatial and spectral resolution with clinical PCCT. Performing co-clinical research will facilitate the translation of novel imaging algorithms and NP contrast agents for PCCT.

Duke Scholars

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

EISSN

1996-756X

ISSN

0277-786X

Publication Date

January 1, 2022

Volume

12304

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering
 

Citation

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Badea, C. T., Clark, D. P., Alphin, A., Ramirez-Giraldo, J. C., Bhandari, P., Mowery, Y. M., & Ghaghada, K. B. (2022). Co-clinical photon counting CT research for multi-contrast imaging. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 12304). https://doi.org/10.1117/12.2646399
Badea, C. T., D. P. Clark, A. Alphin, J. C. Ramirez-Giraldo, P. Bhandari, Y. M. Mowery, and K. B. Ghaghada. “Co-clinical photon counting CT research for multi-contrast imaging.” In Proceedings of SPIE - The International Society for Optical Engineering, Vol. 12304, 2022. https://doi.org/10.1117/12.2646399.
Badea CT, Clark DP, Alphin A, Ramirez-Giraldo JC, Bhandari P, Mowery YM, et al. Co-clinical photon counting CT research for multi-contrast imaging. In: Proceedings of SPIE - The International Society for Optical Engineering. 2022.
Badea, C. T., et al. “Co-clinical photon counting CT research for multi-contrast imaging.” Proceedings of SPIE - The International Society for Optical Engineering, vol. 12304, 2022. Scopus, doi:10.1117/12.2646399.
Badea CT, Clark DP, Alphin A, Ramirez-Giraldo JC, Bhandari P, Mowery YM, Ghaghada KB. Co-clinical photon counting CT research for multi-contrast imaging. Proceedings of SPIE - The International Society for Optical Engineering. 2022.

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

EISSN

1996-756X

ISSN

0277-786X

Publication Date

January 1, 2022

Volume

12304

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering