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Measurement and modeling of 4D live mouse heart volumes from CT time series

Publication ,  Conference
Wetzel, AW; Badea, CT; Pomerantz, SM; Mistry, N; Nave, D; Johnson, GA
Published in: Proceedings of SPIE - The International Society for Optical Engineering
January 1, 2007

In vivo quantitative studies of cardiac function in mouse models provide information about cardiac pathophysiology in more detail than can be obtained in humans. Quantitative measurements of left ventricular (LV) volume at multiple contractile phases are particularly important. However, the mouse heart's small size and rapid motion present challenges for precise measurement in live animals. Researchers at Duke University's Center for In Vivo Microscopy (CIVM) have developed noninvasive time-gated microcomputed tomography (micro-CT) techniques providing the temporal and spatial resolutions required for in vivo characterization of cardiac structure and function. This paper describes analysis of the resulting reconstructions to produce volume measurements and corresponding models of heart motion. We believe these are the most precise noninvasive estimates of in vivo LV volume currently available. Our technique uses binary mixture models to directly recover volume estimates from reconstructed datasets. Unlike methods using segmentation followed by voxel counting, this approach provides statistical error estimates and maintains good precision at high noise levels. This is essential for long term multiple session experiments that must simultaneously minimize contrast agent and x-ray doses. The analysis tools are built into the Pittsburgh Supercomputing Center's Volume Browser (PSC-VB) that provides networked multi-site data sharing and collaboration including analysis and visualization functions. © 2007 SPIE-IS&T.

Duke Scholars

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

ISSN

0277-786X

Publication Date

January 1, 2007

Volume

6491

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering
 

Citation

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Wetzel, A. W., Badea, C. T., Pomerantz, S. M., Mistry, N., Nave, D., & Johnson, G. A. (2007). Measurement and modeling of 4D live mouse heart volumes from CT time series. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 6491). https://doi.org/10.1117/12.704792
Wetzel, A. W., C. T. Badea, S. M. Pomerantz, N. Mistry, D. Nave, and G. A. Johnson. “Measurement and modeling of 4D live mouse heart volumes from CT time series.” In Proceedings of SPIE - The International Society for Optical Engineering, Vol. 6491, 2007. https://doi.org/10.1117/12.704792.
Wetzel AW, Badea CT, Pomerantz SM, Mistry N, Nave D, Johnson GA. Measurement and modeling of 4D live mouse heart volumes from CT time series. In: Proceedings of SPIE - The International Society for Optical Engineering. 2007.
Wetzel, A. W., et al. “Measurement and modeling of 4D live mouse heart volumes from CT time series.” Proceedings of SPIE - The International Society for Optical Engineering, vol. 6491, 2007. Scopus, doi:10.1117/12.704792.
Wetzel AW, Badea CT, Pomerantz SM, Mistry N, Nave D, Johnson GA. Measurement and modeling of 4D live mouse heart volumes from CT time series. Proceedings of SPIE - The International Society for Optical Engineering. 2007.

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

ISSN

0277-786X

Publication Date

January 1, 2007

Volume

6491

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering