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Resolution-enhancing hybrid, spectral CT reconstruction

Publication ,  Conference
Clark, DP; Badea, CT
Published in: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
January 1, 2016

Spectral x-ray imaging based on photon-counting x-ray detectors (PCXD) is an area of growing interest. By measuring the energy of x-ray photons, a spectral CT system can better differentiate elements using a single scan. However, the spatial resolution achievable with most PCXDs limits their application, particularly in preclinical CT imaging. Consequently, our group is developing a hybrid micro-CT scanner based on a high-resolution, energy-integrating (EID) detector and a lower-resolution, PCXD. To complement this system, we propose and demonstrate a hybrid, spectral CT reconstruction algorithm which robustly combines the spectral contrast of the PCXD with the spatial resolution of the EID. Specifically, the high-resolution, spectrally resolved data (X) is recovered as the sum of two matrices: one with low column rank (XL) determined from the EID data and one with intensity gradient sparse columns (XS) corresponding to the upsampled spectral contrast obtained from the PCXD data. We test the proposed algorithm in a feasibility study focused on molecular imaging of atherosclerotic plaque using activatable iodine and gold nanoparticles. The results show accurate estimation of material concentrations at increased spatial resolution for a voxel size ratio between the PCXD and the EID of 500 μm3:100 μm3. Specifically, regularized, iterative reconstruction of the MOBY mouse phantom around the K-edges of iodine (33.2 keV) and gold (80.7 keV) reduces the reconstruction error by more than a factor of three relative to least-squares, algebraic reconstruction. Likewise, the material decomposition accuracy into iodine, gold, calcium, and water improves by more than a factor of two.

Duke Scholars

Published In

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

DOI

ISSN

1605-7422

Publication Date

January 1, 2016

Volume

9783
 

Citation

APA
Chicago
ICMJE
MLA
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Clark, D. P., & Badea, C. T. (2016). Resolution-enhancing hybrid, spectral CT reconstruction. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 9783). https://doi.org/10.1117/12.2216935
Clark, D. P., and C. T. Badea. “Resolution-enhancing hybrid, spectral CT reconstruction.” In Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol. 9783, 2016. https://doi.org/10.1117/12.2216935.
Clark DP, Badea CT. Resolution-enhancing hybrid, spectral CT reconstruction. In: Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2016.
Clark, D. P., and C. T. Badea. “Resolution-enhancing hybrid, spectral CT reconstruction.” Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9783, 2016. Scopus, doi:10.1117/12.2216935.
Clark DP, Badea CT. Resolution-enhancing hybrid, spectral CT reconstruction. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2016.

Published In

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

DOI

ISSN

1605-7422

Publication Date

January 1, 2016

Volume

9783