Immunology in the Clinic Review Series; focus on allergies: immunotherapy for food allergy.

Journal Article (Journal Article;Review)

There is no approved therapy for food allergy. The current standard of care is elimination of the triggering food from the diet and accessibility to epinephrine. Immunotherapy is a promising treatment approach. While desensitization to most foods seems feasible, it remains unclear if a permanent state of tolerance is achievable. The research team at Duke is pioneering immunotherapy for food allergies. Work here has evolved over time from small open-label pilot studies to larger randomized designs. Our data show that immunological changes associated with immunotherapy include reduction in mast cell reactivity, decreased basophil responses, decreased specific-immunoglobulin (Ig)E, increased IgG4 and induction of regulatory T cells. Immunotherapy has generated much excitement in the food allergy community; however, further studies are needed before it is ready for clinical use.

Full Text

Duke Authors

Cited Authors

  • Mousallem, T; Burks, AW

Published Date

  • January 2012

Published In

Volume / Issue

  • 167 / 1

Start / End Page

  • 26 - 31

PubMed ID

  • 22132881

Pubmed Central ID

  • PMC3248083

Electronic International Standard Serial Number (EISSN)

  • 1365-2249

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2249.2011.04499.x

Language

  • eng

Conference Location

  • England