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Immunology in the Clinic Review Series; focus on allergies: immunotherapy for food allergy.

Publication ,  Journal Article
Mousallem, T; Burks, AW
Published in: Clin Exp Immunol
January 2012

There is no approved therapy for food allergy. The current standard of care is elimination of the triggering food from the diet and accessibility to epinephrine. Immunotherapy is a promising treatment approach. While desensitization to most foods seems feasible, it remains unclear if a permanent state of tolerance is achievable. The research team at Duke is pioneering immunotherapy for food allergies. Work here has evolved over time from small open-label pilot studies to larger randomized designs. Our data show that immunological changes associated with immunotherapy include reduction in mast cell reactivity, decreased basophil responses, decreased specific-immunoglobulin (Ig)E, increased IgG4 and induction of regulatory T cells. Immunotherapy has generated much excitement in the food allergy community; however, further studies are needed before it is ready for clinical use.

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Published In

Clin Exp Immunol

DOI

EISSN

1365-2249

Publication Date

January 2012

Volume

167

Issue

1

Start / End Page

26 / 31

Location

England

Related Subject Headings

  • T-Lymphocytes, Regulatory
  • Randomized Controlled Trials as Topic
  • Pilot Projects
  • Nut Hypersensitivity
  • Milk Proteins
  • Milk Hypersensitivity
  • Mast Cells
  • Injections, Subcutaneous
  • Immunology
  • Immunoglobulin G
 

Citation

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Mousallem, T., & Burks, A. W. (2012). Immunology in the Clinic Review Series; focus on allergies: immunotherapy for food allergy. Clin Exp Immunol, 167(1), 26–31. https://doi.org/10.1111/j.1365-2249.2011.04499.x
Mousallem, T., and A. W. Burks. “Immunology in the Clinic Review Series; focus on allergies: immunotherapy for food allergy.Clin Exp Immunol 167, no. 1 (January 2012): 26–31. https://doi.org/10.1111/j.1365-2249.2011.04499.x.
Mousallem T, Burks AW. Immunology in the Clinic Review Series; focus on allergies: immunotherapy for food allergy. Clin Exp Immunol. 2012 Jan;167(1):26–31.
Mousallem, T., and A. W. Burks. “Immunology in the Clinic Review Series; focus on allergies: immunotherapy for food allergy.Clin Exp Immunol, vol. 167, no. 1, Jan. 2012, pp. 26–31. Pubmed, doi:10.1111/j.1365-2249.2011.04499.x.
Mousallem T, Burks AW. Immunology in the Clinic Review Series; focus on allergies: immunotherapy for food allergy. Clin Exp Immunol. 2012 Jan;167(1):26–31.
Journal cover image

Published In

Clin Exp Immunol

DOI

EISSN

1365-2249

Publication Date

January 2012

Volume

167

Issue

1

Start / End Page

26 / 31

Location

England

Related Subject Headings

  • T-Lymphocytes, Regulatory
  • Randomized Controlled Trials as Topic
  • Pilot Projects
  • Nut Hypersensitivity
  • Milk Proteins
  • Milk Hypersensitivity
  • Mast Cells
  • Injections, Subcutaneous
  • Immunology
  • Immunoglobulin G