Establishing a framework to implement 4D XCAT phantom for 4D radiotherapy research.

Published

Journal Article

AIMS: To establish a framework to implement the 4D integrated extended cardiac torso (XCAT) digital phantom for 4D radiotherapy (RT) research. MATERIALS AND METHODS: A computer program was developed to facilitate the characterization and implementation of the 4D XCAT phantom. The program can (1) generate 4D XCAT images with customized parameter files; (2) review 4D XCAT images; (3) generate composite images from 4D XCAT images; (4) track motion of selected region-of-interested (ROI); (5) convert XCAT raw binary images into DICOM format; (6) analyse clinically acquired 4DCT images and real-time position management (RPM) respiratory signal. Motion tracking algorithm was validated by comparing with manual method. Major characteristics of the 4D XCAT phantom were studied. RESULTS: The comparison between motion tracking and manual measurements of lesion motion trajectory showed a small difference between them (mean difference in motion amplitude: 1.2 mm). The maximum lesion motion decreased nearly linearly (R 2 = 0.97) as its distance to the diaphragm (DD) increased. At any given DD, lesion motion amplitude increased nearly linearly (R 2 range: 0.89 to 0.95) as the inputted diaphragm motion increased. For a given diaphragm motion, the lesion motion is independent of the lesion size at any given DD. The 4D XCAT phantom can closely reproduce irregular breathing profile. The end-to-end test showed that clinically comparable treatment plans can be generated successfully based on 4D XCAT images. CONCLUSIONS: An integrated computer program has been developed to generate, review, analyse, process, and export the 4D XCAT images. A framework has been established to implement the 4D XCAT phantom for 4D RT research.

Full Text

Duke Authors

Cited Authors

  • Panta, RK; Segars, P; Yin, F-F; Cai, J

Published Date

  • October 2012

Published In

Volume / Issue

  • 8 / 4

Start / End Page

  • 565 - 570

PubMed ID

  • 23361276

Pubmed Central ID

  • 23361276

Electronic International Standard Serial Number (EISSN)

  • 1998-4138

Digital Object Identifier (DOI)

  • 10.4103/0973-1482.106539

Language

  • eng

Conference Location

  • India