Growth inhibition of pathogenic bacteria by sulfonylurea herbicides.

Journal Article (Journal Article)

Emerging resistance to current antibiotics raises the need for new microbial drug targets. We show that targeting branched-chain amino acid (BCAA) biosynthesis using sulfonylurea herbicides, which inhibit the BCAA biosynthetic enzyme acetohydroxyacid synthase (AHAS), can exert bacteriostatic effects on several pathogenic bacteria, including Burkholderia pseudomallei, Pseudomonas aeruginosa, and Acinetobacter baumannii. Our results suggest that targeting biosynthetic enzymes like AHAS, which are lacking in humans, could represent a promising antimicrobial drug strategy.

Full Text

Duke Authors

Cited Authors

  • Kreisberg, JF; Ong, NT; Krishna, A; Joseph, TL; Wang, J; Ong, C; Ooi, HA; Sung, JC; Siew, CC; Chang, GC; Biot, F; Cuccui, J; Wren, BW; Chan, J; Sivalingam, SP; Zhang, L-H; Verma, C; Tan, P

Published Date

  • March 2013

Published In

Volume / Issue

  • 57 / 3

Start / End Page

  • 1513 - 1517

PubMed ID

  • 23263008

Pubmed Central ID

  • PMC3591922

Electronic International Standard Serial Number (EISSN)

  • 1098-6596

Digital Object Identifier (DOI)

  • 10.1128/AAC.02327-12

Language

  • eng

Conference Location

  • United States