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Growth inhibition of pathogenic bacteria by sulfonylurea herbicides.

Publication ,  Journal Article
Kreisberg, JF; Ong, NT; Krishna, A; Joseph, TL; Wang, J; Ong, C; Ooi, HA; Sung, JC; Siew, CC; Chang, GC; Biot, F; Cuccui, J; Wren, BW ...
Published in: Antimicrobial agents and chemotherapy
March 2013

Emerging resistance to current antibiotics raises the need for new microbial drug targets. We show that targeting branched-chain amino acid (BCAA) biosynthesis using sulfonylurea herbicides, which inhibit the BCAA biosynthetic enzyme acetohydroxyacid synthase (AHAS), can exert bacteriostatic effects on several pathogenic bacteria, including Burkholderia pseudomallei, Pseudomonas aeruginosa, and Acinetobacter baumannii. Our results suggest that targeting biosynthetic enzymes like AHAS, which are lacking in humans, could represent a promising antimicrobial drug strategy.

Duke Scholars

Published In

Antimicrobial agents and chemotherapy

DOI

EISSN

1098-6596

ISSN

0066-4804

Publication Date

March 2013

Volume

57

Issue

3

Start / End Page

1513 / 1517

Related Subject Headings

  • Survival Analysis
  • Sulfonylurea Compounds
  • Pseudomonas aeruginosa
  • Pseudomonas Infections
  • Microbiology
  • Microbial Sensitivity Tests
  • Mice, Inbred BALB C
  • Mice
  • Melioidosis
  • Herbicides
 

Citation

APA
Chicago
ICMJE
MLA
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Kreisberg, J. F., Ong, N. T., Krishna, A., Joseph, T. L., Wang, J., Ong, C., … Tan, P. (2013). Growth inhibition of pathogenic bacteria by sulfonylurea herbicides. Antimicrobial Agents and Chemotherapy, 57(3), 1513–1517. https://doi.org/10.1128/aac.02327-12
Kreisberg, Jason F., Nicholas T. Ong, Aishwarya Krishna, Thomas L. Joseph, Jing Wang, Catherine Ong, Hui Ann Ooi, et al. “Growth inhibition of pathogenic bacteria by sulfonylurea herbicides.Antimicrobial Agents and Chemotherapy 57, no. 3 (March 2013): 1513–17. https://doi.org/10.1128/aac.02327-12.
Kreisberg JF, Ong NT, Krishna A, Joseph TL, Wang J, Ong C, et al. Growth inhibition of pathogenic bacteria by sulfonylurea herbicides. Antimicrobial agents and chemotherapy. 2013 Mar;57(3):1513–7.
Kreisberg, Jason F., et al. “Growth inhibition of pathogenic bacteria by sulfonylurea herbicides.Antimicrobial Agents and Chemotherapy, vol. 57, no. 3, Mar. 2013, pp. 1513–17. Epmc, doi:10.1128/aac.02327-12.
Kreisberg JF, Ong NT, Krishna A, Joseph TL, Wang J, Ong C, Ooi HA, Sung JC, Siew CC, Chang GC, Biot F, Cuccui J, Wren BW, Chan J, Sivalingam SP, Zhang L-H, Verma C, Tan P. Growth inhibition of pathogenic bacteria by sulfonylurea herbicides. Antimicrobial agents and chemotherapy. 2013 Mar;57(3):1513–1517.

Published In

Antimicrobial agents and chemotherapy

DOI

EISSN

1098-6596

ISSN

0066-4804

Publication Date

March 2013

Volume

57

Issue

3

Start / End Page

1513 / 1517

Related Subject Headings

  • Survival Analysis
  • Sulfonylurea Compounds
  • Pseudomonas aeruginosa
  • Pseudomonas Infections
  • Microbiology
  • Microbial Sensitivity Tests
  • Mice, Inbred BALB C
  • Mice
  • Melioidosis
  • Herbicides