The immune system in aging: roles of cytokines, T cells and NK cells.

Journal Article (Review;Journal Article)

Aging is characterized by a proinflammatory state that contributes to the onset of disability and age-related diseases. Proinflammatory cytokines play a central role in mediating cellular and physiological responses. The levels of these cytokines may reflect immune system effectiveness. Studies of the effects of aging on inflammatory response show interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) to be important. In this review, age-related changes in inflammatory cytokines, T and NK cells, and the biology of IL-6 and TNF-alpha and their relevance to senescence are considered.

Full Text

Duke Authors

Cited Authors

  • Huang, H; Patel, DD; Manton, KG

Published Date

  • January 2005

Published In

Volume / Issue

  • 10 /

Start / End Page

  • 192 - 215

PubMed ID

  • 15574362

International Standard Serial Number (ISSN)

  • 1093-9946

Digital Object Identifier (DOI)

  • 10.2741/1521


  • eng