The immune system in aging: roles of cytokines, T cells and NK cells.
Journal Article (Review;Journal Article)
Aging is characterized by a proinflammatory state that contributes to the onset of disability and age-related diseases. Proinflammatory cytokines play a central role in mediating cellular and physiological responses. The levels of these cytokines may reflect immune system effectiveness. Studies of the effects of aging on inflammatory response show interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) to be important. In this review, age-related changes in inflammatory cytokines, T and NK cells, and the biology of IL-6 and TNF-alpha and their relevance to senescence are considered.
Full Text
Duke Authors
Cited Authors
- Huang, H; Patel, DD; Manton, KG
Published Date
- January 2005
Published In
Volume / Issue
- 10 /
Start / End Page
- 192 - 215
PubMed ID
- 15574362
International Standard Serial Number (ISSN)
- 1093-9946
Digital Object Identifier (DOI)
- 10.2741/1521
Language
- eng