The immune system in aging: roles of cytokines, T cells and NK cells.
Publication
, Journal Article
Huang, H; Patel, DD; Manton, KG
Published in: Frontiers in bioscience : a journal and virtual library
January 2005
Aging is characterized by a proinflammatory state that contributes to the onset of disability and age-related diseases. Proinflammatory cytokines play a central role in mediating cellular and physiological responses. The levels of these cytokines may reflect immune system effectiveness. Studies of the effects of aging on inflammatory response show interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) to be important. In this review, age-related changes in inflammatory cytokines, T and NK cells, and the biology of IL-6 and TNF-alpha and their relevance to senescence are considered.
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Published In
Frontiers in bioscience : a journal and virtual library
DOI
ISSN
1093-9946
Publication Date
January 2005
Volume
10
Start / End Page
192 / 215
Related Subject Headings
- Tumor Necrosis Factor-alpha
- Thymus Gland
- T-Lymphocytes
- Osteoporosis
- Killer Cells, Natural
- Interleukin-6
- Inflammation
- Immune System
- Humans
- Cytokines
Citation
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Chicago
ICMJE
MLA
NLM
Huang, H., Patel, D. D., & Manton, K. G. (2005). The immune system in aging: roles of cytokines, T cells and NK cells. Frontiers in Bioscience : A Journal and Virtual Library, 10, 192–215. https://doi.org/10.2741/1521
Huang, Hai, Dhavalkumar D. Patel, and Kenneth G. Manton. “The immune system in aging: roles of cytokines, T cells and NK cells.” Frontiers in Bioscience : A Journal and Virtual Library 10 (January 2005): 192–215. https://doi.org/10.2741/1521.
Huang H, Patel DD, Manton KG. The immune system in aging: roles of cytokines, T cells and NK cells. Frontiers in bioscience : a journal and virtual library. 2005 Jan;10:192–215.
Huang, Hai, et al. “The immune system in aging: roles of cytokines, T cells and NK cells.” Frontiers in Bioscience : A Journal and Virtual Library, vol. 10, Jan. 2005, pp. 192–215. Epmc, doi:10.2741/1521.
Huang H, Patel DD, Manton KG. The immune system in aging: roles of cytokines, T cells and NK cells. Frontiers in bioscience : a journal and virtual library. 2005 Jan;10:192–215.
Published In
Frontiers in bioscience : a journal and virtual library
DOI
ISSN
1093-9946
Publication Date
January 2005
Volume
10
Start / End Page
192 / 215
Related Subject Headings
- Tumor Necrosis Factor-alpha
- Thymus Gland
- T-Lymphocytes
- Osteoporosis
- Killer Cells, Natural
- Interleukin-6
- Inflammation
- Immune System
- Humans
- Cytokines