Keloids treated with excision followed by radiation therapy.
BACKGROUND: In the treatment of keloids surgical excision followed by radiation therapy provides the highest reported control rates of 72% to 92%. OBJECTIVE: We evaluated the effectiveness of excision followed by radiation therapy in the treatment of keloids and compared the efficacy of orthovoltage and electron beam radiation. METHODS: One hundred twenty-six keloids were treated with radiation therapy after surgical excision. Median follow-up period was 12 years. Recurrence rate, side effects, and effectiveness of therapy were assessed. Data were analyzed with multivariate analysis for significant objective and subjective factors. RESULTS: Higher posttreatment recurrence rates were noted with keloids forming at infected sites and in patients with a family history. No increased likelihood of recurrence was noted with respect to patient age, sex, or ethnicity; keloid size or location; individual keloid history; or prior therapy or radiation type used. CONCLUSION: Excision followed by radiation therapy is a useful and effective method of keloid eradication, particularly in cases in which lesions are disfiguring or refractory. Electron beam radiation offers no advantage over orthovoltage as a treatment.
Duke Scholars
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Related Subject Headings
- Treatment Outcome
- Time Factors
- Risk Factors
- Retrospective Studies
- Recurrence
- Radiotherapy, High-Energy
- Radiotherapy Dosage
- Male
- Keloid
- Humans
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Treatment Outcome
- Time Factors
- Risk Factors
- Retrospective Studies
- Recurrence
- Radiotherapy, High-Energy
- Radiotherapy Dosage
- Male
- Keloid
- Humans