Keloids treated with excision followed by radiation therapy.

Journal Article (Journal Article)

BACKGROUND: In the treatment of keloids surgical excision followed by radiation therapy provides the highest reported control rates of 72% to 92%. OBJECTIVE: We evaluated the effectiveness of excision followed by radiation therapy in the treatment of keloids and compared the efficacy of orthovoltage and electron beam radiation. METHODS: One hundred twenty-six keloids were treated with radiation therapy after surgical excision. Median follow-up period was 12 years. Recurrence rate, side effects, and effectiveness of therapy were assessed. Data were analyzed with multivariate analysis for significant objective and subjective factors. RESULTS: Higher posttreatment recurrence rates were noted with keloids forming at infected sites and in patients with a family history. No increased likelihood of recurrence was noted with respect to patient age, sex, or ethnicity; keloid size or location; individual keloid history; or prior therapy or radiation type used. CONCLUSION: Excision followed by radiation therapy is a useful and effective method of keloid eradication, particularly in cases in which lesions are disfiguring or refractory. Electron beam radiation offers no advantage over orthovoltage as a treatment.

Full Text

Duke Authors

Cited Authors

  • Klumpar, DI; Murray, JC; Anscher, M

Published Date

  • August 1994

Published In

Volume / Issue

  • 31 / 2 Pt 1

Start / End Page

  • 225 - 231

PubMed ID

  • 8040405

International Standard Serial Number (ISSN)

  • 0190-9622

Digital Object Identifier (DOI)

  • 10.1016/s0190-9622(94)70152-0


  • eng

Conference Location

  • United States