John Carroll Murray
Professor of Dermatology
My current clinic trials are examining how biologic therapies may control psoriasis. These trials are attempting to identify psoriasis patients not responding to TNF-antagonists and changing the biologic strategy to control psoriasis . Other trials are using new biologic agents, such as a monoclonal antibody to IL-22 to assess the efficacy and safety in treating psoriasis.
Our keloid clinic is a specialty clinic intended to study etiologies and treatmnet options for these disfiguring fibrotic tumors. At this time we do not have any trials active for keloids.
We have completed trials using topical antioxidants for UV protection form reactive oxygen species. Other trials have studies novel topical antifungal agents for onychomycosis ( laureth -4)
Our keloid clinic is a specialty clinic intended to study etiologies and treatmnet options for these disfiguring fibrotic tumors. At this time we do not have any trials active for keloids.
We have completed trials using topical antioxidants for UV protection form reactive oxygen species. Other trials have studies novel topical antifungal agents for onychomycosis ( laureth -4)
Current Appointments & Affiliations
- Professor of Dermatology, Dermatology, Clinical Science Departments 2006
Contact Information
- 3339 Hosp South, Durham, NC 27710
- Duke Box 2907, Durham, NC 27710
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murra013@mc.duke.edu
(919) 684-2393
- Background
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Education, Training, & Certifications
- M.D., Duke University 1977
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Previous Appointments & Affiliations
- Associate Professor of Dermatology in the Department of Medicine, Dermatology, Clinical Science Departments 1994 - 2006
- Associate Clinical Professor of Dermatology in the Department of Medicine, Dermatology, Clinical Science Departments 1994
- Assistant Professor of Medicine, Medicine, Clinical Science Departments 1983 - 1994
- Associate in the Department of Medicine, Medicine, Clinical Science Departments 1982 - 1983
- Research
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Selected Grants
- A Prospective, Multicenter, Long-Term Study to Assess the Safety and Efficacy of Nemolizumab (CD14152) in Subjects with Moderate-to-Severe Atopic Dermatitis awarded by Galderma 2020 - 2022
- A phase 3 pivotal study (118161/118169) and open-label extension (118163) to assess the efficacy and safety of nemolizumab (CD14152) in moderate-to-severe atopic dermatitis subjects and associated pr awarded by Galderma 2020 - 2022
- Multi-center, double-blind, randomised, placebo-controlled, phase IIb dose-finding study to evaluate efficacy and safety of different subcutaneous doses of BI 655130 in patients with moderate to severe Palmoplantar Pustulosis (PPP) awarded by Boehringer Ingelheim Pharmaceuticals, Inc. 2019 - 2021
- Targeting Immune Dysregulation in Psoriasis awarded by SILAB 2017 - 2021
- Corrona Psoriasis Registry (Corrona-PSO-500) awarded by Corrona, Inc. 2015 - 2020
- A Multi-Center, Randomized, Double-Blind, Placebo-and Active Comparator-Controlled Phase 3 Study to Evaluate the Efficacy and Safety of BMS-986165 in Subjects with Moderate-to-Severe Plaque Psoriasis awarded by Bristol-Myers Squibb Company 2019 - 2020
- BI 655066 versus placebo In a Multicenter randomized double-blind study in patients with Moderate to severe cHronic plAque psoriasis evaluatiNg the effiCacy and safety with randomized withdrawal and rE-treatment (IMMhance) awarded by Boehringer Ingelheim Pharmaceuticals, Inc. 2016 - 2020
- A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO EVALUATE SAFETY AND EFFICACY OF PF-04965842 IN SUBJECTS WITH MODERATE TO SEVERE PSORIASIS. awarded by Pfizer, Inc. 2015 - 2016
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Murray, John C., James A. Burch, Robert D. Streilein, Mary Ann Iannacchione, Russell P. Hall, and Sheldon R. Pinnell. “A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation.” J Am Acad Dermatol 59, no. 3 (September 2008): 418–25. https://doi.org/10.1016/j.jaad.2008.05.004.Full Text Link to Item
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Fangman, William L., M Angelica Selim, and John C. Murray. “Diffuse hypopigmented macules.” Arch Dermatol 142, no. 2 (February 2006): 235–40. https://doi.org/10.1001/archderm.142.2.235-a.Full Text Link to Item
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Stern, Robert S., and Robert S. PUVA Follow-up Study. “Inpatient hospital care for psoriasis: a vanishing practice in the United States.” J Am Acad Dermatol 49, no. 3 (September 2003): 445–50. https://doi.org/10.1067/s0190-9622(03)00858-2.Full Text Link to Item
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Lucas, Chere R., Linda L. Sanders, John C. Murray, Sarah A. Myers, Russell P. Hall, and James M. Grichnik. “Early melanoma detection: nonuniform dermoscopic features and growth.” J Am Acad Dermatol 48, no. 5 (May 2003): 663–71. https://doi.org/10.1067/mjd.2003.283.Full Text Link to Item
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DeBuys, H. V., S. B. Levy, J. C. Murray, D. L. Madey, and S. R. Pinnell. “Modern approaches to photoprotection.” Dermatol Clin 18, no. 4 (October 2000): 577–90. https://doi.org/10.1016/s0733-8635(05)70208-4.Full Text Link to Item
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Stern, R. S., L. H. Väkevä, and L. H. PUVA Follow-up Study. “Noncutaneous malignant tumors in the PUVA follow-up study: 1975-1996.” J Invest Dermatol 108, no. 6 (June 1997): 897–900. https://doi.org/10.1111/1523-1747.ep12292698.Full Text Link to Item
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Stern, R. S., and K. T. Nichols. “Therapy with orally administered methoxsalen and ultraviolet A radiation during childhood increases the risk of basal cell carcinoma. The PUVA Follow-up Study.” J Pediatr 129, no. 6 (December 1996): 915–17. https://doi.org/10.1016/s0022-3476(96)70039-2.Full Text Link to Item
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Berg, D., J. A. Garcia, W. A. Schell, J. R. Perfect, and J. C. Murray. “Cutaneous infection caused by Curvularia pallescens: a case report and review of the spectrum of disease.” J Am Acad Dermatol 32, no. 2 Pt 2 (February 1995): 375–78. https://doi.org/10.1016/0190-9622(95)90408-5.Full Text Link to Item
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Stern, R. S. “Ocular lens findings in patients treated with PUVA. Photochemotherapy Follow-Up-Study.” J Invest Dermatol 103, no. 4 (October 1994): 534–38. https://doi.org/10.1111/1523-1747.ep12395733.Full Text Link to Item
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Darling, T. N., N. Sidhu-Malik, G. R. Corey, N. B. Allen, H. Kamino, and J. C. Murray. “Treatment of Mycobacterium haemophilum infection with an antibiotic regimen including clarithromycin.” Br J Dermatol 131, no. 3 (September 1994): 376–79. https://doi.org/10.1111/j.1365-2133.1994.tb08528.x.Full Text Link to Item
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Klumpar, D. I., J. C. Murray, and M. Anscher. “Keloids treated with excision followed by radiation therapy.” J Am Acad Dermatol 31, no. 2 Pt 1 (August 1994): 225–31. https://doi.org/10.1016/s0190-9622(94)70152-0.Full Text Link to Item
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Murray, J. C. “Keloids and hypertrophic scars.” Clin Dermatol 12, no. 1 (1994): 27–37. https://doi.org/10.1016/0738-081x(94)90254-2.Full Text Link to Item
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Murray, J. C. “Scars and keloids.” Dermatol Clin 11, no. 4 (October 1993): 697–708.Link to Item
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Hall, R. P., J. C. Murray, M. M. McCord, M. J. Rico, and R. D. Streilein. “Rabbits immunized with a peptide encoded for by the 230-kD bullous pemphigoid antigen cDNA develop an enhanced inflammatory response to UVB irradiation: a potential animal model for bullous pemphigoid.” J Invest Dermatol 101, no. 1 (July 1993): 9–14. https://doi.org/10.1111/1523-1747.ep12358276.Full Text Link to Item
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Darling, T. N., H. Kamino, and J. C. Murray. “Acquired cutaneous smooth muscle hamartoma.” J Am Acad Dermatol 28, no. 5 Pt 2 (May 1993): 844–45. https://doi.org/10.1016/0190-9622(93)70114-9.Full Text Link to Item
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Darwin, B. S., A. J. Herzberg, J. C. Murray, and E. A. Olsen. “Generalized papular xanthomatosis in mycosis fungoides.” J Am Acad Dermatol 26, no. 5 Pt 2 (May 1992): 828–32. https://doi.org/10.1016/0190-9622(92)70115-v.Full Text Link to Item
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Russell, L. C., and J. Murray. “Patient education: recommendations regarding sunscreens, drugs, and diet.” Ann Plast Surg 28, no. 1 (January 1992): 14–16. https://doi.org/10.1097/00000637-199201000-00006.Full Text Link to Item
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Blum, F., G. Gilkeson, C. Greenberg, and J. Murray. “Superficial migratory thrombophlebitis and the lupus anticoagulant.” Int J Dermatol 29, no. 3 (April 1990): 190–92. https://doi.org/10.1111/j.1365-4362.1990.tb03797.x.Full Text Link to Item
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Murray, J. C. “Pregnancy and the skin.” Dermatol Clin 8, no. 2 (April 1990): 327–34.Link to Item
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McCormack, K., D. Kaplan, J. C. Murray, and B. F. Fetter. “Multiple hairy pacinian neurofibromas (nerve-sheath myxomas).” J Am Acad Dermatol 18, no. 2 Pt 2 (February 1988): 416–19. https://doi.org/10.1016/s0190-9622(88)70060-2.Full Text Link to Item
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Pestana, A., E. A. Olsen, E. R. Delong, and J. C. Murray. “Effect of ultraviolet light on topical minoxidil-induced hair growth in advanced male pattern baldness.” J Am Acad Dermatol 16, no. 5 Pt 1 (May 1987): 971–76. https://doi.org/10.1016/s0190-9622(87)70123-6.Full Text Link to Item
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Fisher, S. R., G. V. Burton, J. C. Murray, M. Borowitz, and I. R. Crocker. “Primary cutaneous lymphoma of the head and neck.” Laryngoscope 96, no. 6 (June 1986): 653–55. https://doi.org/10.1288/00005537-198606000-00011.Full Text Link to Item
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Pizzo, S. V., J. C. Murray, and S. L. Gonias. “Atrophie blanche. A disorder associated with defective release of tissue plasminogen activator.” Arch Pathol Lab Med 110, no. 6 (June 1986): 517–19.Link to Item
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Patterson, J. W., M. Ali, J. C. Murray, and T. A. Hazra. “Bullous pemphigoid. Occurrence in a patient with mycosis fungoides receiving PUVA and topical nitrogen mustard therapy.” Int J Dermatol 24, no. 3 (April 1985): 173–76. https://doi.org/10.1111/j.1365-4362.1985.tb05751.x.Full Text Link to Item
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Patterson, J. W., M. Ali, J. C. Murray, and J. A. Hazka. “Bullous Pemphigoid: Occurrence in a Patient with Mycosis Fungoides Receiving PUVA and Topical Nitrogen Mustard Therapy.” International Journal of Dermatology 24, no. 1 (January 1, 1985): 173–76. https://doi.org/10.1111/j.1365-4362.1985.tb05416.x.Full Text
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Gange, R. W., P. Levins, J. Murray, R. R. Anderson, and J. A. Parrish. “Prolonged skin photosensitization induced by methoxsalen and subphototoxic UVA irradiation.” J Invest Dermatol 82, no. 3 (March 1984): 219–22. https://doi.org/10.1111/1523-1747.ep12260043.Full Text Link to Item
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Murray, J. C., S. V. Pollack, and S. R. Pinnell. “Keloids and hypertrophic scars.” Clin Dermatol 2, no. 3 (1984): 121–33. https://doi.org/10.1016/0738-081x(84)90035-x.Full Text Link to Item
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Murray, J. C., R. S. Gilgor, and G. S. Lazarus. “Serum triglyceride elevation following high-dose vitamin A treatment for pityriasis rubra pilaris.” Arch Dermatol 119, no. 8 (August 1983): 675–76.Link to Item
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Murray, J. C., S. V. Pollack, and S. R. Pinnell. “Keloids: a review.” J Am Acad Dermatol 4, no. 4 (April 1981): 461–70. https://doi.org/10.1016/s0190-9622(81)70048-3.Full Text Link to Item
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Murray, J. C., K. A. Lindberg, and S. R. Pinnell. “In vitro inhibition of chick embryo lysyl hydroxylase by homogentisic acid. A proposed connective tissue defect in alkaptonuria.” J Clin Invest 59, no. 6 (June 1977): 1071–79. https://doi.org/10.1172/JCI108730.Full Text Link to Item
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Murray, J. C., R. H. Cassell, and S. R. Pinnell. “Inhibition of lysyl hydroxylase by catechol analogs.” Biochim Biophys Acta 481, no. 1 (March 15, 1977): 63–70. https://doi.org/10.1016/0005-2744(77)90137-1.Full Text Link to Item
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Murray, J. C., K. A. Lindberg, and S. R. Pinnell. “In vitro inhibition of collagen cross links by catechol analogs.” J Invest Dermatol 68, no. 3 (March 1977): 146–50. https://doi.org/10.1111/1523-1747.ep12492467.Full Text Link to Item
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