John Carroll Murray | Scholars@Duke

John Carroll Murray
Professor of Dermatology

My current clinic trials are examining how biologic therapies may control psoriasis. These trials are attempting to identify psoriasis patients not responding to TNF-antagonists and changing the biologic strategy to control psoriasis . Other trials are using new biologic agents, such as a monoclonal antibody to IL-22 to assess the efficacy and safety in treating psoriasis.
Our keloid clinic is a specialty clinic intended to study etiologies and treatmnet options for these disfiguring fibrotic tumors. At this time we do not have any trials active for keloids.
We have completed trials using topical antioxidants for UV protection form reactive oxygen species. Other trials have studies novel topical antifungal agents for onychomycosis ( laureth -4)

Current Appointments & Affiliations

Professor of Dermatology, Dermatology, Clinical Science Departments 2006

Contact Information

3339 Hosp South, Durham, NC 27710
Duke Box 2907, Durham, NC 27710
murra013@mc.duke.edu (919) 684-2393

Background
Education, Training, & Certifications
- M.D., Duke University 1977
Duke Appointment History
- Associate Professor of Dermatology in the Department of Medicine, Dermatology, Clinical Science Departments 1994 - 2006
- Associate Clinical Professor of Dermatology in the Department of Medicine, Dermatology, Clinical Science Departments 1994
- Assistant Professor of Medicine, Medicine, Clinical Science Departments 1983 - 1994
- Associate in the Department of Medicine, Medicine, Clinical Science Departments 1982 - 1983
Research
Selected Grants
- Corrona Psoriasis Registry (Corrona-PSO-500) awarded by Corrona, Inc. 2015 - 2028
- A Multi-Center, Randomized, Double-Blind, Placebo-and Active Comparator-Controlled Phase 3 Study to Evaluate the Efficacy and Safety of BMS-986165 in Subjects with Moderate-to-Severe Plaque Psoriasis awarded by Bristol-Myers Squibb Company 2019 - 2021
- BI 655066 in moderate to severe chronic plaque psoriasis with randomized withdrawal and re-treatment awarded by Boehringer Ingelheim Pharmaceuticals, Inc. 2016 - 2020
- Targeting Immune Dysregulation in Psoriasis awarded by SILAB 2017 - 2020
- A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO EVALUATE SAFETY AND EFFICACY OF PF-04965842 IN SUBJECTS WITH MODERATE TO SEVERE PSORIASIS. awarded by Pfizer, Inc. 2015 - 2016
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Murray, JC, Burch, JA, Streilein, RD, Iannacchione, MA, Hall, RP, and Pinnell, SR. "A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation." J Am Acad Dermatol 59, no. 3 (September 2008): 418-425. Full Text Link to Item
  - Fangman, WL, Selim, MA, and Murray, JC. "Diffuse hypopigmented macules." Arch Dermatol 142, no. 2 (February 2006): 235-240. Full Text Link to Item
  - Lucas, CR, Sanders, LL, Murray, JC, Myers, SA, Hall, RP, and Grichnik, JM. "Early melanoma detection: nonuniform dermoscopic features and growth." Journal of the American Academy of Dermatology 48, no. 5 (May 2003): 663-671. Full Text
  - Stern, RS, Bauer, E, Epstein, JH, Koo, J, Wolf, J, Niagra, TP, Anderson, TF, Prystowsky, J, McEvoy, M, Taylor, JR, Zaias, N, Urbach, F, Stern, R, Baughman, RD, Braverman, IM, Murray, J, Werth, V, Parrish, J, and Sober, A. "Inpatient hospital care for psoriasis: A vanishing practice in the United States." Journal of the American Academy of Dermatology 49, no. 3 (2003): 445-450. Full Text
  - DeBuys, HV, Levy, SB, Murray, JC, Madey, DL, and Pinnell, SR. "Modern approaches to photoprotection." Dermatol Clin 18, no. 4 (October 2000): 577-590. (Review) Link to Item
  - Stern, RS, Väkevä, LH, Bauer, E, Koo, J, Epstein, JH, Wolf, J, Nigra, TP, Anderson, TF, Prystowsky, J, McEvoy, M, Taylor, JR, Zaias, N, Urbach, F, Arndt, KA, Baughman, RD, Braverman, IM, Murray, J, Werth, V, Fitzpatrick, TB, Parrish, J, and Sober, A. "Noncutaneous malignant tumors in the PUVA follow-up study: 1975-1996." Journal of Investigative Dermatology 108, no. 6 (1997): 897-900.
  - Stern, RS, Nichols, KT, Bauer, E, Koo, J, Epstein, JH, Wolf, J, Nigra, TP, Voorhees, J, Anderson, TF, Prystowsky, J, Muller, S, McEvoy, M, Taylor, JR, Zaias, N, Urbach, F, Arndt, KA, Baughman, RD, Braverman, IM, Murray, J, Werth, V, and Sober, A. "Therapy with orally administered methoxsalen and ultraviolet A radiation during childhood increases the risk of basal cell carcinoma." Journal of Pediatrics 129, no. 6 (1996): 915-917.
  - Berg, D, Garcia, JA, Schell, WA, Perfect, JR, and Murray, JC. "Cutaneous infection caused by Curvularia pallescens: a case report and review of the spectrum of disease." J Am Acad Dermatol 32, no. 2 Pt 2 (February 1995): 375-378. (Review) Link to Item
  - Berg, D, Garcia, JA, Schell, WA, Perfect, JR, and Murray, JC. "Cutaneous infection caused by Curvularia pallescens: A case report and review of the spectrum of disease." Journal of the American Academy of Dermatology 32, no. 2 PART 2 (January 1, 1995): 375-378. (Review) Full Text
  - Stern, RS. "Ocular lens findings in patients treated with PUVA. Photochemotherapy Follow-Up-Study." The Journal of Investigative Dermatology 103, no. 4 (October 1994): 534-538. Full Text
  - Darling, TN, Sidhu-Malik, N, Corey, GR, Allen, NB, Kamino, H, and Murray, JC. "Treatment of Mycobacterium haemophilum infection with an antibiotic regimen including clarithromycin." Br J Dermatol 131, no. 3 (September 1994): 376-379. Link to Item
  - Klumpar, DI, Murray, JC, and Anscher, M. "Keloids treated with excision followed by radiation therapy." Journal of the American Academy of Dermatology 31, no. 2 (January 1, 1994): 225-231. Full Text
  - Murray, JC. "Keloids and hypertrophic scars." Clinics in Dermatology 12, no. 1 (January 1994): 27-37. (Review) Full Text
  - Murray, JC. "Scars and keloids." Dermatologic Clinics 11, no. 4 (October 1993): 697-708. (Review) Full Text
  - Hall, RP, Murray, JC, McCord, MM, Rico, MJ, and Streilein, RD. "Rabbits immunized with a peptide encoded for by the 230-kD bullous pemphigoid antigen cDNA develop an enhanced inflammatory response to UVB irradiation: a potential animal model for bullous pemphigoid." J Invest Dermatol 101, no. 1 (July 1993): 9-14. Link to Item
  - Darling, TN, Kamino, H, and Murray, JC. "Acquired cutaneous smooth muscle hamartoma." Journal of the American Academy of Dermatology 28, no. 5 (January 1, 1993): 844-845. Full Text
  - Darwin, BS, Herzberg, AJ, Murray, JC, and Olsen, EA. "Generalized papular xanthomatosis in mycosis fungoides." Journal of the American Academy of Dermatology 26, no. 5 (May 1992): 828-832. Full Text
  - Russell, LC, and Murray, J. "Patient education: Recommendations regarding sunscreens, drugs, and diet." Annals of Plastic Surgery 28, no. 1 (1992): 14-16.
  - Murray, JC. "Pregnancy and the skin." Dermatologic Clinics 8, no. 2 (April 1990): 327-334. (Review) Full Text
  - Blum, F, Gilkeson, G, Greenberg, C, and Murray, J. "Superficial migratory thrombophlebitis and the lupus anticoagulant." International Journal of Dermatology 29, no. 3 (1990): 190-192.
  - McCormack, K, Kaplan, D, Murray, JC, and Fetter, BF. "Multiple hairy pacinian neurofibromas (nerve-sheath myxomas)." Journal of the American Academy of Dermatology 18, no. 2 (February 1988): 416-419. Full Text
  - Pestana, A, Olsen, EA, Delong, ER, and Murray, JC. "Effect of ultraviolet light on topical minoxidil-induced hair growth in advanced male pattern baldness." Journal of the American Academy of Dermatology 16, no. 5 (January 1, 1987): 971-976. Full Text
  - Fisher, SR, Burton, GV, Murray, JC, Borowitz, M, and Crocker, IR. "Primary cutaneous lymphoma of the head and neck." Laryngoscope 96, no. 6 (June 1986): 653-655. Link to Item
  - Pizzo, SV, Murray, JC, and Gonias, SL. "Atrophie blanche. A disorder associated with defective release of tissue plasminogen activator." Archives of Pathology & Laboratory Medicine 110, no. 6 (June 1986): 517-519.
  - Patterson, JW, Ali, M, Murray, JC, and Hazka, JA. "Bullous Pemphigoid: Occurrence in a Patient with Mycosis Fungoides Receiving PUVA and Topical Nitrogen Mustard Therapy." International Journal of Dermatology 24, no. 1 (January 1, 1985): 173-176. Full Text
  - Patterson, JW, Ali, M, Murray, JC, and Hazra, TA. "Bullous pemphigoid. Occurrence in a patient with mycosis fungoides receiving PUVA and topical nitrogen mustard therapy." International Journal of Dermatology 24, no. 3 (1985): 173-176.
  - Murray, JC, Pollack, SV, and Pinnell, SR. "Keloids and hypertrophic scars." Clin Dermatol 2, no. 3 (July 1984): 121-133. Link to Item
  - Gange, RW, Levins, P, Murray, J, Anderson, RR, and Parrish, JA. "Prolonged skin photosensitization induced by methoxsalen and subphototoxic UVA irradiation." Journal of Investigative Dermatology 82, no. 3 (1984): 219-222.
  - Murray, JC, Gilgor, RS, and Lazarus, GS. "Serum triglyceride elevation following high-dose vitamin A treatment for pityriasis rubra pilaris." Archives of Dermatology 119, no. 8 (August 1983): 675-676. Full Text
  - Murray, JC, Pollack, SV, and Pinnell, SR. "Keloids: a review." J Am Acad Dermatol 4, no. 4 (April 1981): 461-470. (Review) Link to Item
  - Murray, JC, Lindberg, KA, and Pinnell, SR. "In vitro inhibition of chick embryo lysyl hydroxylase by homogentisic acid. A proposed connective tissue defect in alkaptonuria." J Clin Invest 59, no. 6 (June 1977): 1071-1079. Full Text Link to Item
  - Murray, JC, Cassell, RH, and Pinnell, SR. "Inhibition of lysyl hydroxylase by catechol analogs." Biochim Biophys Acta 481, no. 1 (March 15, 1977): 63-70. Link to Item
  - Murray, JC, Lindberg, KA, and Pinnell, SR. "In vitro inhibition of collagen cross links by catechol analogs." J Invest Dermatol 68, no. 3 (March 1977): 146-150. Link to Item

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles