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John Carroll Murray

Professor of Dermatology
Dermatology
2234 Crooked Creek Pkwy, Durham, NC 27713
234 Crooked Creek Pkwy, Durham, NC 27713

Selected Publications


Bilateral eccrine angiomatous hamartomas of the proximal interphalangeal joints.

Journal Article Dermatol Online J · April 15, 2023 Eccrine angiomatous hamartoma is an uncommon, benign clinical entity constituting a nodular proliferation of eccrine glands and vascular structures localized to the dermis that typically present as unilateral, flesh-colored, erythematous, or violaceous pap ... Full text Link to item Cite

A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation.

Journal Article J Am Acad Dermatol · September 2008 BACKGROUND: Skin cancer and photoaging changes result from ultraviolet (UV)-induced oxidative stress. Topical antioxidants may protect skin from these effects. OBJECTIVE: We sought to determine whether a stable topical formulation of 15% L-ascorbic acid, 1 ... Full text Link to item Cite

Diffuse hypopigmented macules.

Journal Article Arch Dermatol · February 2006 Full text Link to item Cite

Inpatient hospital care for psoriasis: a vanishing practice in the United States.

Journal Article J Am Acad Dermatol · September 2003 BACKGROUND: Inpatient hospital care was a traditional approach to treat severe psoriasis. Since 1980, only modest innovations in psoriasis therapy have been introduced, but regulation and financing of inpatient hospital care have changed greatly. OBJECTIVE ... Full text Link to item Cite

Early melanoma detection: nonuniform dermoscopic features and growth.

Journal Article J Am Acad Dermatol · May 2003 BACKGROUND: Dermoscopy alone is not sufficient to detect all early melanomas. Total body photos reveal growth of melanomas but also reveal growth of melanocytic nevi. OBJECTIVE: We set out to determine whether a simplified algorithm on the basis of nonunif ... Full text Link to item Cite

Modern approaches to photoprotection.

Journal Article Dermatol Clin · October 2000 UV light reacts with skin to produce undesirable changes, including photoaging and skin cancer. Sunscreen strategies are useful for protection against UV-B and short-wave UV-A, but complete protection against long-wave UV-A has not been achieved. Because U ... Full text Link to item Cite

Noncutaneous malignant tumors in the PUVA follow-up study: 1975-1996.

Journal Article J Invest Dermatol · June 1997 There is concern about possible association between PUVA treatment and an increased risk of noncutaneous cancer. An alteration in the risk of cancer among persons with psoriasis has also been postulated. To test this hypothesis, for nearly two decades we h ... Full text Link to item Cite

Therapy with orally administered methoxsalen and ultraviolet A radiation during childhood increases the risk of basal cell carcinoma. The PUVA Follow-up Study.

Journal Article J Pediatr · December 1996 A child was treated from age 18 months to 8 years with oral methoxsalen and ultraviolet A radiation (PUVA) for refractory psoriasis. Two basal cell cancers developed before age 21 years, suggesting that exposure to PUVA in childhood increases the risk of b ... Full text Link to item Cite

Cutaneous infection caused by Curvularia pallescens: a case report and review of the spectrum of disease.

Journal Article J Am Acad Dermatol · February 1995 A 75-year-old woman being treated with prednisone and methotrexate had a 5.5 x 2.2 cm ulcer on the leg. A biopsy specimen revealed suppurative, granulomatous dermal inflammation with necrotic areas of septate, branching hyphae containing brown pigment. Cul ... Full text Link to item Cite

Ocular lens findings in patients treated with PUVA. Photochemotherapy Follow-Up-Study.

Journal Article J Invest Dermatol · October 1994 In some animal species, exposure of the ocular lens to 8-methoxypsoralen (8-MOP) and ultraviolet-A radiation (PUVA) induces lens opacities. Case reports have suggested that PUVA therapy in humans may be associated with an increased risk of ocular lens abno ... Full text Link to item Cite

Treatment of Mycobacterium haemophilum infection with an antibiotic regimen including clarithromycin.

Journal Article Br J Dermatol · September 1994 A patient with rheumatoid arthritis developed ulcerated nodules predominantly on his legs. Skin biopsy and culture demonstrated rheumatoid vasculitis and infection with Mycobacterium haemophilum. Improvement was not seen until clarithromycin was added to h ... Full text Link to item Cite

Keloids treated with excision followed by radiation therapy.

Journal Article J Am Acad Dermatol · August 1994 BACKGROUND: In the treatment of keloids surgical excision followed by radiation therapy provides the highest reported control rates of 72% to 92%. OBJECTIVE: We evaluated the effectiveness of excision followed by radiation therapy in the treatment of keloi ... Full text Link to item Cite

Keloids and hypertrophic scars.

Journal Article Clin Dermatol · 1994 Full text Link to item Cite

Scars and keloids.

Journal Article Dermatol Clin · October 1993 Despite the disfigurement and symptoms from these abnormal wound responses, the literature offers little consensus about appropriate therapy. Few prospective blinded studies have been performed to compare therapeutic options. Multiple therapies have been r ... Link to item Cite

Rabbits immunized with a peptide encoded for by the 230-kD bullous pemphigoid antigen cDNA develop an enhanced inflammatory response to UVB irradiation: a potential animal model for bullous pemphigoid.

Journal Article J Invest Dermatol · July 1993 Previous attempts to develop an animal model of bullous pemphigoid (BP) have failed to result in inflammatory disease in the skin. P1-2 is an 18-amino acid peptide encoded for by the 230-kD BP antigen cDNA that has been shown to contain an epitope recogniz ... Full text Link to item Cite

Acquired cutaneous smooth muscle hamartoma.

Journal Article J Am Acad Dermatol · May 1993 A 35-year-old white man had an indurated, indistinct plaque on the anterior aspect of the neck for 10 years. Results of biopsy specimens showed an excess of smooth muscle bundles scattered throughout the dermis. Unlike previously reported cases of acquired ... Full text Link to item Cite

Generalized papular xanthomatosis in mycosis fungoides.

Journal Article J Am Acad Dermatol · May 1992 Xanthomas can occur in association with underlying lymphoproliferative disease, or they can result from lipid deposition in damaged or altered skin. We report a case of generalized papular xanthomas that developed in a patient with Sézary syndrome. The xan ... Full text Link to item Cite

Patient education: recommendations regarding sunscreens, drugs, and diet.

Journal Article Ann Plast Surg · January 1992 Early recognition of melanoma is directly related to improvement in survival. Patients, therefore, must not only be educated in recognition of abnormal skin lesions, but also in proper skin examination, ultraviolet radiation protection, effect of drugs on ... Full text Link to item Cite

Superficial migratory thrombophlebitis and the lupus anticoagulant.

Journal Article Int J Dermatol · April 1990 The lupus anticoagulant is an antiphospholipid antibody found in association with systemic lupus erythematosus and in a variety of other diseases, as well as in healthy individuals. In the laboratory, the antibody interferes with the conversion of prothrom ... Full text Link to item Cite

Pregnancy and the skin.

Journal Article Dermatol Clin · April 1990 Physiologic skin changes and certain dermatoses characteristically occur during pregnancy. Any cutaneous change is rarely ignored, as the patient is concerned about her own and her fetus's well-being. Physiologic changes include pigmentation, vascular grow ... Link to item Cite

Bilateral eccrine angiomatous hamartomas of the proximal interphalangeal joints.

Journal Article Dermatol Online J · April 15, 2023 Eccrine angiomatous hamartoma is an uncommon, benign clinical entity constituting a nodular proliferation of eccrine glands and vascular structures localized to the dermis that typically present as unilateral, flesh-colored, erythematous, or violaceous pap ... Full text Link to item Cite

A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation.

Journal Article J Am Acad Dermatol · September 2008 BACKGROUND: Skin cancer and photoaging changes result from ultraviolet (UV)-induced oxidative stress. Topical antioxidants may protect skin from these effects. OBJECTIVE: We sought to determine whether a stable topical formulation of 15% L-ascorbic acid, 1 ... Full text Link to item Cite

Diffuse hypopigmented macules.

Journal Article Arch Dermatol · February 2006 Full text Link to item Cite

Inpatient hospital care for psoriasis: a vanishing practice in the United States.

Journal Article J Am Acad Dermatol · September 2003 BACKGROUND: Inpatient hospital care was a traditional approach to treat severe psoriasis. Since 1980, only modest innovations in psoriasis therapy have been introduced, but regulation and financing of inpatient hospital care have changed greatly. OBJECTIVE ... Full text Link to item Cite

Early melanoma detection: nonuniform dermoscopic features and growth.

Journal Article J Am Acad Dermatol · May 2003 BACKGROUND: Dermoscopy alone is not sufficient to detect all early melanomas. Total body photos reveal growth of melanomas but also reveal growth of melanocytic nevi. OBJECTIVE: We set out to determine whether a simplified algorithm on the basis of nonunif ... Full text Link to item Cite

Modern approaches to photoprotection.

Journal Article Dermatol Clin · October 2000 UV light reacts with skin to produce undesirable changes, including photoaging and skin cancer. Sunscreen strategies are useful for protection against UV-B and short-wave UV-A, but complete protection against long-wave UV-A has not been achieved. Because U ... Full text Link to item Cite

Noncutaneous malignant tumors in the PUVA follow-up study: 1975-1996.

Journal Article J Invest Dermatol · June 1997 There is concern about possible association between PUVA treatment and an increased risk of noncutaneous cancer. An alteration in the risk of cancer among persons with psoriasis has also been postulated. To test this hypothesis, for nearly two decades we h ... Full text Link to item Cite

Therapy with orally administered methoxsalen and ultraviolet A radiation during childhood increases the risk of basal cell carcinoma. The PUVA Follow-up Study.

Journal Article J Pediatr · December 1996 A child was treated from age 18 months to 8 years with oral methoxsalen and ultraviolet A radiation (PUVA) for refractory psoriasis. Two basal cell cancers developed before age 21 years, suggesting that exposure to PUVA in childhood increases the risk of b ... Full text Link to item Cite

Cutaneous infection caused by Curvularia pallescens: a case report and review of the spectrum of disease.

Journal Article J Am Acad Dermatol · February 1995 A 75-year-old woman being treated with prednisone and methotrexate had a 5.5 x 2.2 cm ulcer on the leg. A biopsy specimen revealed suppurative, granulomatous dermal inflammation with necrotic areas of septate, branching hyphae containing brown pigment. Cul ... Full text Link to item Cite

Ocular lens findings in patients treated with PUVA. Photochemotherapy Follow-Up-Study.

Journal Article J Invest Dermatol · October 1994 In some animal species, exposure of the ocular lens to 8-methoxypsoralen (8-MOP) and ultraviolet-A radiation (PUVA) induces lens opacities. Case reports have suggested that PUVA therapy in humans may be associated with an increased risk of ocular lens abno ... Full text Link to item Cite

Treatment of Mycobacterium haemophilum infection with an antibiotic regimen including clarithromycin.

Journal Article Br J Dermatol · September 1994 A patient with rheumatoid arthritis developed ulcerated nodules predominantly on his legs. Skin biopsy and culture demonstrated rheumatoid vasculitis and infection with Mycobacterium haemophilum. Improvement was not seen until clarithromycin was added to h ... Full text Link to item Cite

Keloids treated with excision followed by radiation therapy.

Journal Article J Am Acad Dermatol · August 1994 BACKGROUND: In the treatment of keloids surgical excision followed by radiation therapy provides the highest reported control rates of 72% to 92%. OBJECTIVE: We evaluated the effectiveness of excision followed by radiation therapy in the treatment of keloi ... Full text Link to item Cite

Keloids and hypertrophic scars.

Journal Article Clin Dermatol · 1994 Full text Link to item Cite

Scars and keloids.

Journal Article Dermatol Clin · October 1993 Despite the disfigurement and symptoms from these abnormal wound responses, the literature offers little consensus about appropriate therapy. Few prospective blinded studies have been performed to compare therapeutic options. Multiple therapies have been r ... Link to item Cite

Rabbits immunized with a peptide encoded for by the 230-kD bullous pemphigoid antigen cDNA develop an enhanced inflammatory response to UVB irradiation: a potential animal model for bullous pemphigoid.

Journal Article J Invest Dermatol · July 1993 Previous attempts to develop an animal model of bullous pemphigoid (BP) have failed to result in inflammatory disease in the skin. P1-2 is an 18-amino acid peptide encoded for by the 230-kD BP antigen cDNA that has been shown to contain an epitope recogniz ... Full text Link to item Cite

Acquired cutaneous smooth muscle hamartoma.

Journal Article J Am Acad Dermatol · May 1993 A 35-year-old white man had an indurated, indistinct plaque on the anterior aspect of the neck for 10 years. Results of biopsy specimens showed an excess of smooth muscle bundles scattered throughout the dermis. Unlike previously reported cases of acquired ... Full text Link to item Cite

Generalized papular xanthomatosis in mycosis fungoides.

Journal Article J Am Acad Dermatol · May 1992 Xanthomas can occur in association with underlying lymphoproliferative disease, or they can result from lipid deposition in damaged or altered skin. We report a case of generalized papular xanthomas that developed in a patient with Sézary syndrome. The xan ... Full text Link to item Cite

Patient education: recommendations regarding sunscreens, drugs, and diet.

Journal Article Ann Plast Surg · January 1992 Early recognition of melanoma is directly related to improvement in survival. Patients, therefore, must not only be educated in recognition of abnormal skin lesions, but also in proper skin examination, ultraviolet radiation protection, effect of drugs on ... Full text Link to item Cite

Superficial migratory thrombophlebitis and the lupus anticoagulant.

Journal Article Int J Dermatol · April 1990 The lupus anticoagulant is an antiphospholipid antibody found in association with systemic lupus erythematosus and in a variety of other diseases, as well as in healthy individuals. In the laboratory, the antibody interferes with the conversion of prothrom ... Full text Link to item Cite

Pregnancy and the skin.

Journal Article Dermatol Clin · April 1990 Physiologic skin changes and certain dermatoses characteristically occur during pregnancy. Any cutaneous change is rarely ignored, as the patient is concerned about her own and her fetus's well-being. Physiologic changes include pigmentation, vascular grow ... Link to item Cite

Multiple hairy pacinian neurofibromas (nerve-sheath myxomas).

Journal Article J Am Acad Dermatol · February 1988 Pacinian neurofibromas are unusual tumors with components that resemble Vater-Pacini corpuscles and are probably a variant of nerve-sheath myxoma. Lesions composed predominantly of these structures have occurred on or near the buttocks in three previously ... Full text Link to item Cite

Effect of ultraviolet light on topical minoxidil-induced hair growth in advanced male pattern baldness.

Journal Article J Am Acad Dermatol · May 1987 Nine healthy men with type IVa or Va male pattern baldness completed a 4-month single-blinded controlled pilot study designed to assess the effect of ultraviolet light (UVL) on topical minoxidil-induced hair growth. Subjects applied 2% topical minoxidil so ... Full text Link to item Cite

Primary cutaneous lymphoma of the head and neck.

Journal Article Laryngoscope · June 1986 One hundred three patients with Stage I and II extranodal primary lymphomas of the head and neck were reviewed. Six patients (5%) presented with cutaneous lesions, five with single site and one with multiple sites of involvement. Histopathology was maligna ... Full text Link to item Cite

Atrophie blanche. A disorder associated with defective release of tissue plasminogen activator.

Journal Article Arch Pathol Lab Med · June 1986 Atrophie blanche is a skin disorder characterized by recurrent ulceration and fibrosis. It is one of a group of cutaneous vasculitides associated with decreased blood fibrinolytic activity. We examined pre- and post-venous occlusion plasma from eight patie ... Link to item Cite

Bullous pemphigoid. Occurrence in a patient with mycosis fungoides receiving PUVA and topical nitrogen mustard therapy.

Journal Article Int J Dermatol · April 1985 A 57-year-old woman with mycosis fungoides developed blisters within cutaneous plaques while receiving PUVA therapy and topical nitrogen mustard. Direct and indirect immunofluorescence studies showed the findings of bullous pemphigoid. Her bullous disease ... Full text Link to item Cite

Bullous Pemphigoid: Occurrence in a Patient with Mycosis Fungoides Receiving PUVA and Topical Nitrogen Mustard Therapy

Journal Article International Journal of Dermatology · January 1, 1985 Abstract: A 57‐year‐old woman with mycosis fungoides developed blisters within cutaneous plaques while receiving PUVA therapy and topical nitrogen mustard. Direct and indirect immunofluorescence studies showed the findings of bullous pemphigoid. Her bullou ... Full text Cite

Prolonged skin photosensitization induced by methoxsalen and subphototoxic UVA irradiation.

Journal Article J Invest Dermatol · March 1984 Topical 8-methoxypsoralen (8-MOP) was used to briefly provide free psoralen sufficient for marked cutaneous photosensitization, but only a small dose of UVA was delivered initially, in an effort to produce many monoadducts but few crosslinks. After ample t ... Full text Link to item Cite

Keloids and hypertrophic scars.

Journal Article Clin Dermatol · 1984 Full text Link to item Cite

Serum triglyceride elevation following high-dose vitamin A treatment for pityriasis rubra pilaris.

Journal Article Arch Dermatol · August 1983 We describe two patients with pityriasis rubra pilaris in whom hypertriglyceridemia developed following the oral administration of high-dose vitamin A (retinol). The effects of transient hypertriglyceridemia are unknown, as both patients tolerated high-dos ... Link to item Cite

Keloids: a review.

Journal Article J Am Acad Dermatol · April 1981 Keloids are predominantly fibrous tumors which appear as firm, variably pruritic or tender growths near a site of injury. Usually appearing between the ages of 10 and 30, most keloids are located on the upper back, shoulders, earlobes, and anterior portion ... Full text Link to item Cite

In vitro inhibition of chick embryo lysyl hydroxylase by homogentisic acid. A proposed connective tissue defect in alkaptonuria.

Journal Article J Clin Invest · June 1977 Homogentisic acid inhibits the in vitro activity of chick embryo lysyl hydroxylase, a microsomal enzyme which catalyzes the transformation of certain lysyl residues in collagen to hydroxylysine. Chick embryo lysyl hydroxylase activity was measured as speci ... Full text Link to item Cite

Inhibition of lysyl hydroxylase by catechol analogs.

Journal Article Biochim Biophys Acta · March 15, 1977 Catechol analogs inhibit the activity of lysyl hydroxylase (peptidyllysine, 2-oxyglutarate: oxygen 5-oxidoreductase, EC 1.14.11.4), a microsomal enzyme which catalyzes the transformation of certain lysyl residues in collagen to hydroxylysine. Chick embryo ... Full text Link to item Cite

In vitro inhibition of collagen cross links by catechol analogs.

Journal Article J Invest Dermatol · March 1977 Catechol analogs inhibit the formation of hydroxylysine-derived intermolecular collagen cross links in tissue cultures of chick embryo calvaria. Formation of intermolecular collagen cross links was measured following incorporation of [14C]lysine, reduction ... Full text Link to item Cite