Journal ArticleDermatol Online J · April 15, 2023
Eccrine angiomatous hamartoma is an uncommon, benign clinical entity constituting a nodular proliferation of eccrine glands and vascular structures localized to the dermis that typically present as unilateral, flesh-colored, erythematous, or violaceous pap ...
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Journal ArticleJ Am Acad Dermatol · September 2008
BACKGROUND: Skin cancer and photoaging changes result from ultraviolet (UV)-induced oxidative stress. Topical antioxidants may protect skin from these effects. OBJECTIVE: We sought to determine whether a stable topical formulation of 15% L-ascorbic acid, 1 ...
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Journal ArticleJ Am Acad Dermatol · September 2003
BACKGROUND: Inpatient hospital care was a traditional approach to treat severe psoriasis. Since 1980, only modest innovations in psoriasis therapy have been introduced, but regulation and financing of inpatient hospital care have changed greatly. OBJECTIVE ...
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Journal ArticleJ Am Acad Dermatol · May 2003
BACKGROUND: Dermoscopy alone is not sufficient to detect all early melanomas. Total body photos reveal growth of melanomas but also reveal growth of melanocytic nevi. OBJECTIVE: We set out to determine whether a simplified algorithm on the basis of nonunif ...
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Journal ArticleDermatol Clin · October 2000
UV light reacts with skin to produce undesirable changes, including photoaging and skin cancer. Sunscreen strategies are useful for protection against UV-B and short-wave UV-A, but complete protection against long-wave UV-A has not been achieved. Because U ...
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Journal ArticleJ Invest Dermatol · June 1997
There is concern about possible association between PUVA treatment and an increased risk of noncutaneous cancer. An alteration in the risk of cancer among persons with psoriasis has also been postulated. To test this hypothesis, for nearly two decades we h ...
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Journal ArticleJ Pediatr · December 1996
A child was treated from age 18 months to 8 years with oral methoxsalen and ultraviolet A radiation (PUVA) for refractory psoriasis. Two basal cell cancers developed before age 21 years, suggesting that exposure to PUVA in childhood increases the risk of b ...
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Journal ArticleJ Am Acad Dermatol · February 1995
A 75-year-old woman being treated with prednisone and methotrexate had a 5.5 x 2.2 cm ulcer on the leg. A biopsy specimen revealed suppurative, granulomatous dermal inflammation with necrotic areas of septate, branching hyphae containing brown pigment. Cul ...
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Journal ArticleJ Invest Dermatol · October 1994
In some animal species, exposure of the ocular lens to 8-methoxypsoralen (8-MOP) and ultraviolet-A radiation (PUVA) induces lens opacities. Case reports have suggested that PUVA therapy in humans may be associated with an increased risk of ocular lens abno ...
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Journal ArticleBr J Dermatol · September 1994
A patient with rheumatoid arthritis developed ulcerated nodules predominantly on his legs. Skin biopsy and culture demonstrated rheumatoid vasculitis and infection with Mycobacterium haemophilum. Improvement was not seen until clarithromycin was added to h ...
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Journal ArticleJ Am Acad Dermatol · August 1994
BACKGROUND: In the treatment of keloids surgical excision followed by radiation therapy provides the highest reported control rates of 72% to 92%. OBJECTIVE: We evaluated the effectiveness of excision followed by radiation therapy in the treatment of keloi ...
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Journal ArticleDermatol Clin · October 1993
Despite the disfigurement and symptoms from these abnormal wound responses, the literature offers little consensus about appropriate therapy. Few prospective blinded studies have been performed to compare therapeutic options. Multiple therapies have been r ...
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Journal ArticleJ Invest Dermatol · July 1993
Previous attempts to develop an animal model of bullous pemphigoid (BP) have failed to result in inflammatory disease in the skin. P1-2 is an 18-amino acid peptide encoded for by the 230-kD BP antigen cDNA that has been shown to contain an epitope recogniz ...
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Journal ArticleJ Am Acad Dermatol · May 1993
A 35-year-old white man had an indurated, indistinct plaque on the anterior aspect of the neck for 10 years. Results of biopsy specimens showed an excess of smooth muscle bundles scattered throughout the dermis. Unlike previously reported cases of acquired ...
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Journal ArticleJ Am Acad Dermatol · May 1992
Xanthomas can occur in association with underlying lymphoproliferative disease, or they can result from lipid deposition in damaged or altered skin. We report a case of generalized papular xanthomas that developed in a patient with Sézary syndrome. The xan ...
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Journal ArticleAnn Plast Surg · January 1992
Early recognition of melanoma is directly related to improvement in survival. Patients, therefore, must not only be educated in recognition of abnormal skin lesions, but also in proper skin examination, ultraviolet radiation protection, effect of drugs on ...
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Journal ArticleInt J Dermatol · April 1990
The lupus anticoagulant is an antiphospholipid antibody found in association with systemic lupus erythematosus and in a variety of other diseases, as well as in healthy individuals. In the laboratory, the antibody interferes with the conversion of prothrom ...
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Journal ArticleDermatol Clin · April 1990
Physiologic skin changes and certain dermatoses characteristically occur during pregnancy. Any cutaneous change is rarely ignored, as the patient is concerned about her own and her fetus's well-being. Physiologic changes include pigmentation, vascular grow ...
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Journal ArticleDermatol Online J · April 15, 2023
Eccrine angiomatous hamartoma is an uncommon, benign clinical entity constituting a nodular proliferation of eccrine glands and vascular structures localized to the dermis that typically present as unilateral, flesh-colored, erythematous, or violaceous pap ...
Full textLink to itemCite
Journal ArticleJ Am Acad Dermatol · September 2008
BACKGROUND: Skin cancer and photoaging changes result from ultraviolet (UV)-induced oxidative stress. Topical antioxidants may protect skin from these effects. OBJECTIVE: We sought to determine whether a stable topical formulation of 15% L-ascorbic acid, 1 ...
Full textLink to itemCite
Journal ArticleJ Am Acad Dermatol · September 2003
BACKGROUND: Inpatient hospital care was a traditional approach to treat severe psoriasis. Since 1980, only modest innovations in psoriasis therapy have been introduced, but regulation and financing of inpatient hospital care have changed greatly. OBJECTIVE ...
Full textLink to itemCite
Journal ArticleJ Am Acad Dermatol · May 2003
BACKGROUND: Dermoscopy alone is not sufficient to detect all early melanomas. Total body photos reveal growth of melanomas but also reveal growth of melanocytic nevi. OBJECTIVE: We set out to determine whether a simplified algorithm on the basis of nonunif ...
Full textLink to itemCite
Journal ArticleDermatol Clin · October 2000
UV light reacts with skin to produce undesirable changes, including photoaging and skin cancer. Sunscreen strategies are useful for protection against UV-B and short-wave UV-A, but complete protection against long-wave UV-A has not been achieved. Because U ...
Full textLink to itemCite
Journal ArticleJ Invest Dermatol · June 1997
There is concern about possible association between PUVA treatment and an increased risk of noncutaneous cancer. An alteration in the risk of cancer among persons with psoriasis has also been postulated. To test this hypothesis, for nearly two decades we h ...
Full textLink to itemCite
Journal ArticleJ Pediatr · December 1996
A child was treated from age 18 months to 8 years with oral methoxsalen and ultraviolet A radiation (PUVA) for refractory psoriasis. Two basal cell cancers developed before age 21 years, suggesting that exposure to PUVA in childhood increases the risk of b ...
Full textLink to itemCite
Journal ArticleJ Am Acad Dermatol · February 1995
A 75-year-old woman being treated with prednisone and methotrexate had a 5.5 x 2.2 cm ulcer on the leg. A biopsy specimen revealed suppurative, granulomatous dermal inflammation with necrotic areas of septate, branching hyphae containing brown pigment. Cul ...
Full textLink to itemCite
Journal ArticleJ Invest Dermatol · October 1994
In some animal species, exposure of the ocular lens to 8-methoxypsoralen (8-MOP) and ultraviolet-A radiation (PUVA) induces lens opacities. Case reports have suggested that PUVA therapy in humans may be associated with an increased risk of ocular lens abno ...
Full textLink to itemCite
Journal ArticleBr J Dermatol · September 1994
A patient with rheumatoid arthritis developed ulcerated nodules predominantly on his legs. Skin biopsy and culture demonstrated rheumatoid vasculitis and infection with Mycobacterium haemophilum. Improvement was not seen until clarithromycin was added to h ...
Full textLink to itemCite
Journal ArticleJ Am Acad Dermatol · August 1994
BACKGROUND: In the treatment of keloids surgical excision followed by radiation therapy provides the highest reported control rates of 72% to 92%. OBJECTIVE: We evaluated the effectiveness of excision followed by radiation therapy in the treatment of keloi ...
Full textLink to itemCite
Journal ArticleDermatol Clin · October 1993
Despite the disfigurement and symptoms from these abnormal wound responses, the literature offers little consensus about appropriate therapy. Few prospective blinded studies have been performed to compare therapeutic options. Multiple therapies have been r ...
Link to itemCite
Journal ArticleJ Invest Dermatol · July 1993
Previous attempts to develop an animal model of bullous pemphigoid (BP) have failed to result in inflammatory disease in the skin. P1-2 is an 18-amino acid peptide encoded for by the 230-kD BP antigen cDNA that has been shown to contain an epitope recogniz ...
Full textLink to itemCite
Journal ArticleJ Am Acad Dermatol · May 1993
A 35-year-old white man had an indurated, indistinct plaque on the anterior aspect of the neck for 10 years. Results of biopsy specimens showed an excess of smooth muscle bundles scattered throughout the dermis. Unlike previously reported cases of acquired ...
Full textLink to itemCite
Journal ArticleJ Am Acad Dermatol · May 1992
Xanthomas can occur in association with underlying lymphoproliferative disease, or they can result from lipid deposition in damaged or altered skin. We report a case of generalized papular xanthomas that developed in a patient with Sézary syndrome. The xan ...
Full textLink to itemCite
Journal ArticleAnn Plast Surg · January 1992
Early recognition of melanoma is directly related to improvement in survival. Patients, therefore, must not only be educated in recognition of abnormal skin lesions, but also in proper skin examination, ultraviolet radiation protection, effect of drugs on ...
Full textLink to itemCite
Journal ArticleInt J Dermatol · April 1990
The lupus anticoagulant is an antiphospholipid antibody found in association with systemic lupus erythematosus and in a variety of other diseases, as well as in healthy individuals. In the laboratory, the antibody interferes with the conversion of prothrom ...
Full textLink to itemCite
Journal ArticleDermatol Clin · April 1990
Physiologic skin changes and certain dermatoses characteristically occur during pregnancy. Any cutaneous change is rarely ignored, as the patient is concerned about her own and her fetus's well-being. Physiologic changes include pigmentation, vascular grow ...
Link to itemCite
Journal ArticleJ Am Acad Dermatol · February 1988
Pacinian neurofibromas are unusual tumors with components that resemble Vater-Pacini corpuscles and are probably a variant of nerve-sheath myxoma. Lesions composed predominantly of these structures have occurred on or near the buttocks in three previously ...
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Journal ArticleJ Am Acad Dermatol · May 1987
Nine healthy men with type IVa or Va male pattern baldness completed a 4-month single-blinded controlled pilot study designed to assess the effect of ultraviolet light (UVL) on topical minoxidil-induced hair growth. Subjects applied 2% topical minoxidil so ...
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Journal ArticleLaryngoscope · June 1986
One hundred three patients with Stage I and II extranodal primary lymphomas of the head and neck were reviewed. Six patients (5%) presented with cutaneous lesions, five with single site and one with multiple sites of involvement. Histopathology was maligna ...
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Journal ArticleArch Pathol Lab Med · June 1986
Atrophie blanche is a skin disorder characterized by recurrent ulceration and fibrosis. It is one of a group of cutaneous vasculitides associated with decreased blood fibrinolytic activity. We examined pre- and post-venous occlusion plasma from eight patie ...
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Journal ArticleInt J Dermatol · April 1985
A 57-year-old woman with mycosis fungoides developed blisters within cutaneous plaques while receiving PUVA therapy and topical nitrogen mustard. Direct and indirect immunofluorescence studies showed the findings of bullous pemphigoid. Her bullous disease ...
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Journal ArticleInternational Journal of Dermatology · January 1, 1985
Abstract: A 57‐year‐old woman with mycosis fungoides developed blisters within cutaneous plaques while receiving PUVA therapy and topical nitrogen mustard. Direct and indirect immunofluorescence studies showed the findings of bullous pemphigoid. Her bullou ...
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Journal ArticleJ Invest Dermatol · March 1984
Topical 8-methoxypsoralen (8-MOP) was used to briefly provide free psoralen sufficient for marked cutaneous photosensitization, but only a small dose of UVA was delivered initially, in an effort to produce many monoadducts but few crosslinks. After ample t ...
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Journal ArticleArch Dermatol · August 1983
We describe two patients with pityriasis rubra pilaris in whom hypertriglyceridemia developed following the oral administration of high-dose vitamin A (retinol). The effects of transient hypertriglyceridemia are unknown, as both patients tolerated high-dos ...
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Journal ArticleJ Am Acad Dermatol · April 1981
Keloids are predominantly fibrous tumors which appear as firm, variably pruritic or tender growths near a site of injury. Usually appearing between the ages of 10 and 30, most keloids are located on the upper back, shoulders, earlobes, and anterior portion ...
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Journal ArticleJ Clin Invest · June 1977
Homogentisic acid inhibits the in vitro activity of chick embryo lysyl hydroxylase, a microsomal enzyme which catalyzes the transformation of certain lysyl residues in collagen to hydroxylysine. Chick embryo lysyl hydroxylase activity was measured as speci ...
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Journal ArticleBiochim Biophys Acta · March 15, 1977
Catechol analogs inhibit the activity of lysyl hydroxylase (peptidyllysine, 2-oxyglutarate: oxygen 5-oxidoreductase, EC 1.14.11.4), a microsomal enzyme which catalyzes the transformation of certain lysyl residues in collagen to hydroxylysine. Chick embryo ...
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Journal ArticleJ Invest Dermatol · March 1977
Catechol analogs inhibit the formation of hydroxylysine-derived intermolecular collagen cross links in tissue cultures of chick embryo calvaria. Formation of intermolecular collagen cross links was measured following incorporation of [14C]lysine, reduction ...
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