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Genetic variation at a single locus and age of onset for Alzheimer's disease.

Publication ,  Journal Article
Lutz, MW; Crenshaw, DG; Saunders, AM; Roses, AD
Published in: Alzheimers Dement
March 2010

This perspective article provides an opportunity to explain a new genetic finding for late-onset Alzheimer's disease (LOAD). It is specifically written for physicians and scientists who are interested in LOAD, but it may be relevant to those interested in identifying susceptibility variants for other complex diseases. The significant finding discussed here is that a variable-length, deoxythymidine homopolymer (poly-T) within intron 6 of the TOMM40 gene is associated with the age of onset of LOAD [Roses AD, Lutz MW, Amrine-Madsen H, Saunders AM, Crenshaw DG, Sundseth SS, et al. A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease. Pharmacogenomics J 2009 December 22;[Epublication ahead of print]. This result was obtained with a phylogenetic study of the genetic polymorphisms that reside within the linkage disequilibrium (LD) block that contains the TOMM40, APOE, and APOC1 genes from patients with LOAD and age-matched subjects without disease. Although the data will have diagnostic, prognostic, and therapeutic strategy implications, this perspective is meant to place the inheritance pattern for this "complex" human disease into context, and to highlight the potential utility of applying phylogenetic tools to the study of the genetics of complex diseases.

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Published In

Alzheimers Dement

DOI

EISSN

1552-5279

Publication Date

March 2010

Volume

6

Issue

2

Start / End Page

125 / 131

Location

United States

Related Subject Headings

  • Prognosis
  • Predictive Value of Tests
  • Polymorphism, Genetic
  • Phylogeny
  • Molecular Biology
  • Mitochondrial Precursor Protein Import Complex Proteins
  • Membrane Transport Proteins
  • Linkage Disequilibrium
  • Humans
  • Geriatrics
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lutz, M. W., Crenshaw, D. G., Saunders, A. M., & Roses, A. D. (2010). Genetic variation at a single locus and age of onset for Alzheimer's disease. Alzheimers Dement, 6(2), 125–131. https://doi.org/10.1016/j.jalz.2010.01.011
Lutz, Michael W., Donna G. Crenshaw, Ann M. Saunders, and Allen D. Roses. “Genetic variation at a single locus and age of onset for Alzheimer's disease.Alzheimers Dement 6, no. 2 (March 2010): 125–31. https://doi.org/10.1016/j.jalz.2010.01.011.
Lutz MW, Crenshaw DG, Saunders AM, Roses AD. Genetic variation at a single locus and age of onset for Alzheimer's disease. Alzheimers Dement. 2010 Mar;6(2):125–31.
Lutz, Michael W., et al. “Genetic variation at a single locus and age of onset for Alzheimer's disease.Alzheimers Dement, vol. 6, no. 2, Mar. 2010, pp. 125–31. Pubmed, doi:10.1016/j.jalz.2010.01.011.
Lutz MW, Crenshaw DG, Saunders AM, Roses AD. Genetic variation at a single locus and age of onset for Alzheimer's disease. Alzheimers Dement. 2010 Mar;6(2):125–131.
Journal cover image

Published In

Alzheimers Dement

DOI

EISSN

1552-5279

Publication Date

March 2010

Volume

6

Issue

2

Start / End Page

125 / 131

Location

United States

Related Subject Headings

  • Prognosis
  • Predictive Value of Tests
  • Polymorphism, Genetic
  • Phylogeny
  • Molecular Biology
  • Mitochondrial Precursor Protein Import Complex Proteins
  • Membrane Transport Proteins
  • Linkage Disequilibrium
  • Humans
  • Geriatrics