Tcf-3 expression and beta-catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour).

Journal Article (Journal Article)

Aggressive fibromatosis harbours mutations resulting in beta-catenin protein stabilization. Primary cell cultures demonstrate constitutive tcf activation in aggressive fibromatosis. Expression and co-immunoprecipitation studies suggest that beta-catenin binds and activates tcf-3 in this tumour. This is the first demonstration of tcf-3 activation by beta-catenin stabilization in a human neoplastic process.

Full Text

Duke Authors

Cited Authors

  • Tejpar, S; Li, C; Yu, C; Poon, R; Denys, H; Sciot, R; Van Cutsem, E; Cassiman, JJ; Alman, BA

Published Date

  • July 6, 2001

Published In

Volume / Issue

  • 85 / 1

Start / End Page

  • 98 - 101

PubMed ID

  • 11437409

Pubmed Central ID

  • PMC2363921

International Standard Serial Number (ISSN)

  • 0007-0920

Digital Object Identifier (DOI)

  • 10.1054/bjoc.2001.1857


  • eng

Conference Location

  • England