107 Dose-finding and safety study of an oncolytic polio/rhinovirus recombinant against recurrent glioblastoma.
Publication
, Journal Article
Sampson, JH; Desjardins, A; Peters, KB; Ranjan, T; Vlahovic, G; Lally-Goss, D; Threatt, S; Herndon, J; Friedman, AH; Friedman, H; Bigner, D ...
Published in: Neurosurgery
August 2013
Current therapies for glioblastoma are limited by ineffective delivery beyond the blood-brain barrier, limited diffusion of regionally-delivered macromolecules, and lack of tumor specificity. Sustained direct intracerebral infusion at slow flow rates [convection-enhanced delivery (CED)] can overcome delivery barriers. PVSRIPO is the live attenuated, oral (SABIN) serotype 1 poliovirus vaccine containing a heterologous internal ribosomal entry site stemming from human rhinovirus type 2. PVSRIPO recognizes nectin-like molecule-5, an oncofetal cell adhesion molecule and tumor antigen widely expressed ectopically in malignancy. We are reporting results of an ongoing phase I study evaluating PVSRIPO via CED delivery.
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Published In
Neurosurgery
DOI
EISSN
1524-4040
Publication Date
August 2013
Volume
60 Suppl 1
Start / End Page
155
Location
United States
Related Subject Headings
- Neurology & Neurosurgery
- 1109 Neurosciences
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Sampson, J. H., Desjardins, A., Peters, K. B., Ranjan, T., Vlahovic, G., Lally-Goss, D., … Gromeier, M. (2013). 107 Dose-finding and safety study of an oncolytic polio/rhinovirus recombinant against recurrent glioblastoma. Neurosurgery, 60 Suppl 1, 155. https://doi.org/10.1227/01.neu.0000432699.02392.a4
Sampson, J. H., A. Desjardins, K. B. Peters, T. Ranjan, G. Vlahovic, D. Lally-Goss, S. Threatt, et al. “107 Dose-finding and safety study of an oncolytic polio/rhinovirus recombinant against recurrent glioblastoma.” Neurosurgery 60 Suppl 1 (August 2013): 155. https://doi.org/10.1227/01.neu.0000432699.02392.a4.
Sampson JH, Desjardins A, Peters KB, Ranjan T, Vlahovic G, Lally-Goss D, et al. 107 Dose-finding and safety study of an oncolytic polio/rhinovirus recombinant against recurrent glioblastoma. Neurosurgery. 2013 Aug;60 Suppl 1:155.
Sampson, J. H., et al. “107 Dose-finding and safety study of an oncolytic polio/rhinovirus recombinant against recurrent glioblastoma.” Neurosurgery, vol. 60 Suppl 1, Aug. 2013, p. 155. Pubmed, doi:10.1227/01.neu.0000432699.02392.a4.
Sampson JH, Desjardins A, Peters KB, Ranjan T, Vlahovic G, Lally-Goss D, Threatt S, Herndon J, Friedman AH, Friedman H, Bigner D, Gromeier M. 107 Dose-finding and safety study of an oncolytic polio/rhinovirus recombinant against recurrent glioblastoma. Neurosurgery. 2013 Aug;60 Suppl 1:155.
Published In
Neurosurgery
DOI
EISSN
1524-4040
Publication Date
August 2013
Volume
60 Suppl 1
Start / End Page
155
Location
United States
Related Subject Headings
- Neurology & Neurosurgery
- 1109 Neurosciences
- 1103 Clinical Sciences