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Biomarker-guided therapies in heart failure: a forum for unified strategies.

Publication ,  Journal Article
Fiuzat, M; O'Connor, CM; Gueyffier, F; Mascette, AM; Geller, NL; Mebazaa, A; Voors, AA; Adams, KF; Piña, IL; Neyses, L; Muntendam, P; Pitt, B ...
Published in: J Card Fail
August 2013

The complexity of standard medical treatment for heart failure is growing, and such therapy typically involves 5 or more different medications. Given these pressures, there is increasing interest in harnessing cardiovascular biomarkers for clinical application to more effectively guide diagnosis, risk stratification, and therapy. It may be possible to realize an era of personalized medicine for heart failure treatment in which therapy is optimized and costs are controlled. The direct mechanistic coupling of biologic processes and therapies achieved in cancer treatment remains elusive in heart failure. Recent clinical trials and meta-analyses of biomarkers in heart failure have produced conflicting evidence. In this article, which comprises a summary of discussions from the Global Cardiovascular Clinical Trialists Forum held in Paris, France, we offer a brief overview of the background and rationale for biomarker testing in heart failure, describe opportunities and challenges from a regulatory perspective, and summarize current positions from government agencies in the United States and European Union.

Duke Scholars

Published In

J Card Fail

DOI

EISSN

1532-8414

Publication Date

August 2013

Volume

19

Issue

8

Start / End Page

592 / 599

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Randomized Controlled Trials as Topic
  • Paris
  • Humans
  • Heart Failure
  • European Union
  • Europe
  • Cardiovascular System & Hematology
  • Biomarkers
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fiuzat, M., O’Connor, C. M., Gueyffier, F., Mascette, A. M., Geller, N. L., Mebazaa, A., … Bristow, M. R. (2013). Biomarker-guided therapies in heart failure: a forum for unified strategies. J Card Fail, 19(8), 592–599. https://doi.org/10.1016/j.cardfail.2013.05.012
Fiuzat, Mona, Christopher M. O’Connor, Francois Gueyffier, Alice M. Mascette, Nancy L. Geller, Alexandre Mebazaa, Adriaan A. Voors, et al. “Biomarker-guided therapies in heart failure: a forum for unified strategies.J Card Fail 19, no. 8 (August 2013): 592–99. https://doi.org/10.1016/j.cardfail.2013.05.012.
Fiuzat M, O’Connor CM, Gueyffier F, Mascette AM, Geller NL, Mebazaa A, et al. Biomarker-guided therapies in heart failure: a forum for unified strategies. J Card Fail. 2013 Aug;19(8):592–9.
Fiuzat, Mona, et al. “Biomarker-guided therapies in heart failure: a forum for unified strategies.J Card Fail, vol. 19, no. 8, Aug. 2013, pp. 592–99. Pubmed, doi:10.1016/j.cardfail.2013.05.012.
Fiuzat M, O’Connor CM, Gueyffier F, Mascette AM, Geller NL, Mebazaa A, Voors AA, Adams KF, Piña IL, Neyses L, Muntendam P, Felker GM, Pitt B, Zannad F, Bristow MR. Biomarker-guided therapies in heart failure: a forum for unified strategies. J Card Fail. 2013 Aug;19(8):592–599.
Journal cover image

Published In

J Card Fail

DOI

EISSN

1532-8414

Publication Date

August 2013

Volume

19

Issue

8

Start / End Page

592 / 599

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Randomized Controlled Trials as Topic
  • Paris
  • Humans
  • Heart Failure
  • European Union
  • Europe
  • Cardiovascular System & Hematology
  • Biomarkers