General medical burden in bipolar disorder: findings from the LiTMUS comparative effectiveness trial.

Journal Article (Journal Article)

OBJECTIVE: This study examined general medical illnesses and their association with clinical features of bipolar disorder. METHOD: Data were cross-sectional and derived from the Lithium Treatment - Moderate Dose Use Study (LiTMUS), which randomized symptomatic adults (n = 264 with available medical comorbidity scores) with bipolar disorder to moderate doses of lithium plus optimized treatment (OPT) or to OPT alone. Clinically significant high and low medical comorbidity burden were defined as a Cumulative Illness Rating Scale (CIRS) score ≥4 and <4 respectively. RESULTS: The baseline prevalence of significant medical comorbidity was 53% (n = 139). Patients with high medical burden were more likely to present in a major depressive episode (P = .04), meet criteria for obsessive-compulsive disorder (P = .02), and experience a greater number of lifetime mood episodes (P = 0.02). They were also more likely to be prescribed a greater number of psychotropic medications (P = .002). Sixty-nine per cent of the sample was overweight or obese as defined by body mass index (BMI), with African Americans representing the racial group with the highest proportion of stage II obesity (BMI ≥35; 31%, n = 14). CONCLUSION: The burden of comorbid medical illnesses was high in this generalizable sample of treatment-seeking patients and appears associated with worsened course of illness and psychotropic medication patterns.

Full Text

Duke Authors

Cited Authors

  • Kemp, DE; Sylvia, LG; Calabrese, JR; Nierenberg, AA; Thase, ME; Reilly-Harrington, NA; Ostacher, MJ; Leon, AC; Ketter, TA; Friedman, ES; Bowden, CL; Rabideau, DJ; Pencina, M; Iosifescu, DV; LiTMUS Study Group,

Published Date

  • January 2014

Published In

Volume / Issue

  • 129 / 1

Start / End Page

  • 24 - 34

PubMed ID

  • 23465084

Pubmed Central ID

  • PMC3789858

Electronic International Standard Serial Number (EISSN)

  • 1600-0447

Digital Object Identifier (DOI)

  • 10.1111/acps.12101


  • eng

Conference Location

  • United States