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General medical burden in bipolar disorder: findings from the LiTMUS comparative effectiveness trial.

Publication ,  Journal Article
Kemp, DE; Sylvia, LG; Calabrese, JR; Nierenberg, AA; Thase, ME; Reilly-Harrington, NA; Ostacher, MJ; Leon, AC; Ketter, TA; Friedman, ES ...
Published in: Acta Psychiatr Scand
January 2014

OBJECTIVE: This study examined general medical illnesses and their association with clinical features of bipolar disorder. METHOD: Data were cross-sectional and derived from the Lithium Treatment - Moderate Dose Use Study (LiTMUS), which randomized symptomatic adults (n = 264 with available medical comorbidity scores) with bipolar disorder to moderate doses of lithium plus optimized treatment (OPT) or to OPT alone. Clinically significant high and low medical comorbidity burden were defined as a Cumulative Illness Rating Scale (CIRS) score ≥4 and <4 respectively. RESULTS: The baseline prevalence of significant medical comorbidity was 53% (n = 139). Patients with high medical burden were more likely to present in a major depressive episode (P = .04), meet criteria for obsessive-compulsive disorder (P = .02), and experience a greater number of lifetime mood episodes (P = 0.02). They were also more likely to be prescribed a greater number of psychotropic medications (P = .002). Sixty-nine per cent of the sample was overweight or obese as defined by body mass index (BMI), with African Americans representing the racial group with the highest proportion of stage II obesity (BMI ≥35; 31%, n = 14). CONCLUSION: The burden of comorbid medical illnesses was high in this generalizable sample of treatment-seeking patients and appears associated with worsened course of illness and psychotropic medication patterns.

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Published In

Acta Psychiatr Scand

DOI

EISSN

1600-0447

Publication Date

January 2014

Volume

129

Issue

1

Start / End Page

24 / 34

Location

United States

Related Subject Headings

  • Young Adult
  • White People
  • Psychotropic Drugs
  • Psychiatry
  • Overweight
  • Obsessive-Compulsive Disorder
  • Obesity
  • Multivariate Analysis
  • Migraine Disorders
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
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Kemp, D. E., Sylvia, L. G., Calabrese, J. R., Nierenberg, A. A., Thase, M. E., Reilly-Harrington, N. A., … LiTMUS Study Group, . (2014). General medical burden in bipolar disorder: findings from the LiTMUS comparative effectiveness trial. Acta Psychiatr Scand, 129(1), 24–34. https://doi.org/10.1111/acps.12101
Kemp, D. E., L. G. Sylvia, J. R. Calabrese, A. A. Nierenberg, M. E. Thase, N. A. Reilly-Harrington, M. J. Ostacher, et al. “General medical burden in bipolar disorder: findings from the LiTMUS comparative effectiveness trial.Acta Psychiatr Scand 129, no. 1 (January 2014): 24–34. https://doi.org/10.1111/acps.12101.
Kemp DE, Sylvia LG, Calabrese JR, Nierenberg AA, Thase ME, Reilly-Harrington NA, et al. General medical burden in bipolar disorder: findings from the LiTMUS comparative effectiveness trial. Acta Psychiatr Scand. 2014 Jan;129(1):24–34.
Kemp, D. E., et al. “General medical burden in bipolar disorder: findings from the LiTMUS comparative effectiveness trial.Acta Psychiatr Scand, vol. 129, no. 1, Jan. 2014, pp. 24–34. Pubmed, doi:10.1111/acps.12101.
Kemp DE, Sylvia LG, Calabrese JR, Nierenberg AA, Thase ME, Reilly-Harrington NA, Ostacher MJ, Leon AC, Ketter TA, Friedman ES, Bowden CL, Rabideau DJ, Pencina M, Iosifescu DV, LiTMUS Study Group. General medical burden in bipolar disorder: findings from the LiTMUS comparative effectiveness trial. Acta Psychiatr Scand. 2014 Jan;129(1):24–34.
Journal cover image

Published In

Acta Psychiatr Scand

DOI

EISSN

1600-0447

Publication Date

January 2014

Volume

129

Issue

1

Start / End Page

24 / 34

Location

United States

Related Subject Headings

  • Young Adult
  • White People
  • Psychotropic Drugs
  • Psychiatry
  • Overweight
  • Obsessive-Compulsive Disorder
  • Obesity
  • Multivariate Analysis
  • Migraine Disorders
  • Middle Aged