Stem cell therapies for knee cartilage repair: the current status of preclinical and clinical studies.


Journal Article (Review)

BACKGROUND: Articular cartilage damage of the knee is common, causing significant morbidity worldwide. Many adult tissues contain cells that are able to differentiate into multiple cell types, including chondrocytes. These stem cells have gained significant attention over the past decade and may become frontline management for cartilage defects in the very near future. PURPOSE: The role of stem cells in the treatment of knee osteochondral defects was reviewed. Recent animal and clinical studies were reviewed to determine the benefits and potential outcomes of using stem cells for cartilage defects. STUDY DESIGN: Literature review. METHODS: A PubMed search was undertaken. The key phrase "stem cells and knee" was used. The search included reviews and original articles over an unlimited time period. From this search, articles outlining animal and clinical trials were selected. A search of current clinical trials in progress was performed on the website, and "stem cells and knee" was used as the search phrase. RESULTS: Stem cells have been used in many recent in vitro and animal studies. A number of cell-based approaches for cartilage repair have progressed from preclinical animal studies into clinical trials. CONCLUSION: The use of stem cells for the treatment of cartilage defects is increasing in animal and clinical studies. Methods of delivery of stem cells to the knee's cartilage vary from direct injection to implantation with scaffolds. While these approaches are highly promising, there is currently limited evidence of a direct clinical benefit, and further research is required to assess the overall outcome of stem cell therapies for knee cartilage repair.

Full Text

Duke Authors

Cited Authors

  • Anderson, JA; Little, D; Toth, AP; Moorman, CT; Tucker, BS; Ciccotti, MG; Guilak, F

Published Date

  • September 2014

Published In

Volume / Issue

  • 42 / 9

Start / End Page

  • 2253 - 2261

PubMed ID

  • 24220016

Pubmed Central ID

  • 24220016

Electronic International Standard Serial Number (EISSN)

  • 1552-3365

Digital Object Identifier (DOI)

  • 10.1177/0363546513508744


  • eng

Conference Location

  • United States