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Stem cell therapies for knee cartilage repair: the current status of preclinical and clinical studies.

Publication ,  Journal Article
Anderson, JA; Little, D; Toth, AP; Moorman, CT; Tucker, BS; Ciccotti, MG; Guilak, F
Published in: Am J Sports Med
September 2014

BACKGROUND: Articular cartilage damage of the knee is common, causing significant morbidity worldwide. Many adult tissues contain cells that are able to differentiate into multiple cell types, including chondrocytes. These stem cells have gained significant attention over the past decade and may become frontline management for cartilage defects in the very near future. PURPOSE: The role of stem cells in the treatment of knee osteochondral defects was reviewed. Recent animal and clinical studies were reviewed to determine the benefits and potential outcomes of using stem cells for cartilage defects. STUDY DESIGN: Literature review. METHODS: A PubMed search was undertaken. The key phrase "stem cells and knee" was used. The search included reviews and original articles over an unlimited time period. From this search, articles outlining animal and clinical trials were selected. A search of current clinical trials in progress was performed on the clinicaltrials.gov website, and "stem cells and knee" was used as the search phrase. RESULTS: Stem cells have been used in many recent in vitro and animal studies. A number of cell-based approaches for cartilage repair have progressed from preclinical animal studies into clinical trials. CONCLUSION: The use of stem cells for the treatment of cartilage defects is increasing in animal and clinical studies. Methods of delivery of stem cells to the knee's cartilage vary from direct injection to implantation with scaffolds. While these approaches are highly promising, there is currently limited evidence of a direct clinical benefit, and further research is required to assess the overall outcome of stem cell therapies for knee cartilage repair.

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Published In

Am J Sports Med

DOI

EISSN

1552-3365

Publication Date

September 2014

Volume

42

Issue

9

Start / End Page

2253 / 2261

Location

United States

Related Subject Headings

  • Wound Healing
  • Stem Cell Transplantation
  • Orthopedics
  • Knee Injuries
  • Humans
  • Cartilage, Articular
  • Cartilage Diseases
  • Animals
  • 4207 Sports science and exercise
  • 4201 Allied health and rehabilitation science
 

Citation

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Anderson, J. A., Little, D., Toth, A. P., Moorman, C. T., Tucker, B. S., Ciccotti, M. G., & Guilak, F. (2014). Stem cell therapies for knee cartilage repair: the current status of preclinical and clinical studies. Am J Sports Med, 42(9), 2253–2261. https://doi.org/10.1177/0363546513508744
Anderson, John A., Dianne Little, Alison P. Toth, Claude T. Moorman, Bradford S. Tucker, Michael G. Ciccotti, and Farshid Guilak. “Stem cell therapies for knee cartilage repair: the current status of preclinical and clinical studies.Am J Sports Med 42, no. 9 (September 2014): 2253–61. https://doi.org/10.1177/0363546513508744.
Anderson JA, Little D, Toth AP, Moorman CT, Tucker BS, Ciccotti MG, et al. Stem cell therapies for knee cartilage repair: the current status of preclinical and clinical studies. Am J Sports Med. 2014 Sep;42(9):2253–61.
Anderson, John A., et al. “Stem cell therapies for knee cartilage repair: the current status of preclinical and clinical studies.Am J Sports Med, vol. 42, no. 9, Sept. 2014, pp. 2253–61. Pubmed, doi:10.1177/0363546513508744.
Anderson JA, Little D, Toth AP, Moorman CT, Tucker BS, Ciccotti MG, Guilak F. Stem cell therapies for knee cartilage repair: the current status of preclinical and clinical studies. Am J Sports Med. 2014 Sep;42(9):2253–2261.
Journal cover image

Published In

Am J Sports Med

DOI

EISSN

1552-3365

Publication Date

September 2014

Volume

42

Issue

9

Start / End Page

2253 / 2261

Location

United States

Related Subject Headings

  • Wound Healing
  • Stem Cell Transplantation
  • Orthopedics
  • Knee Injuries
  • Humans
  • Cartilage, Articular
  • Cartilage Diseases
  • Animals
  • 4207 Sports science and exercise
  • 4201 Allied health and rehabilitation science