Study design elements for rigorous quasi-experimental comparative effectiveness research

Journal Article (Review)

Quasi-experiments are likely to be the workhorse study design used to generate evidence about the comparative effectiveness of alternative treatments, because of their feasibility, timeliness, affordability and external validity compared with randomized trials. In this review, we outline potential sources of discordance in results between quasi-experiments and experiments, review study design choices that can improve the internal validity of quasi-experiments, and outline innovative data linkage strategies that may be particularly useful in quasi-experimental comparative effectiveness research. There is an urgent need to resolve the debate about the evidentiary value of quasi-experiments since equal consideration of rigorous quasi-experiments will broaden the base of evidence that can be brought to bear in clinical decision-making and governmental policy-making. © 2013 Future Medicine Ltd.

Full Text

Duke Authors

Cited Authors

  • MacIejewski, ML; Curtis, LH; Dowd, B

Published Date

  • March 11, 2013

Published In

Volume / Issue

  • 2 / 2

Start / End Page

  • 159 - 173

PubMed ID

  • 24236558

Electronic International Standard Serial Number (EISSN)

  • 2042-6313

International Standard Serial Number (ISSN)

  • 2042-6305

Digital Object Identifier (DOI)

  • 10.2217/cer.13.7

Citation Source

  • Scopus