Overview
Interested in the fascinating world of plants, microbes or inter-organismal communication and co-evolution? Please contact Prof. Sheng-Yang He (shengyang.he@duke.edu; hes@msu.edu).
Millions of years of co-evolution between plants and microbes have resulted in an intricate web of attack, counter-attack, decoy, and hijacking mechanisms in biology. Moreover, co-evolution between plants and microbes is greatly impacted by ongoing climate change. In our lab, we probe “host-microbe-climate” interactions to answer the following fundamental questions: (1) How do microbial pathogens infect a susceptible host? (2) How do plants select beneficial microbiomes to ensure health? (3) How do climate conditions impact disease and immunity?
We use contemporary methods to address these questions, including those commonly used in molecular genetics, genomics, biochemistry, cell biology, bioinformatics, microbiology, plant biology, co-evolution and infectious disease biology.
Current Appointments & Affiliations
Recent Publications
A bacterial nutrition strategy for plant disease control.
Journal Article Science · December 18, 2025 Xanthomonas spp. cause serious diseases in more than 400 plant species. The conserved AvrBs2 family effectors are among the most important virulence factors in xanthomonads, but how AvrBs2 promotes infection remains elusive. We found that AvrBs2 is a glyce ... Full text Link to item CiteAugmenting rice <i>ANNEXIN</i> expression to counter planthopper <i>Nl</i>Annexin-like5 as an antivirulence strategy against a major crop pest.
Journal Article Proceedings of the National Academy of Sciences of the United States of America · October 2025 The brown planthopper (BPH) is the most devastating insect pest in rice, posing a serious threat to global rice production. One attractive control strategy would be based on the understanding of the virulence mechanisms of BPH at the molecular level and th ... Full text CiteActin Depolymerization Factor (ADF) Moonlighting: Nuclear Immune Regulation by Interacting with WRKY Transcription Factors and Shaping the Transcriptome.
Journal Article bioRxiv · August 23, 2025 Remodeling of the actin cytoskeleton is a critical process for plant immunity, essential for the transport, activation, and stabilization of immune-regulatory molecules and organelles. In this process, actin depolymerization factors (ADFs) function as key ... Full text Link to item CiteRecent Grants
Tri-Institutional Molecular Mycology and Pathogenesis Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029Establishment of an aqueous environment as a novel mechanism of bacterial pathogenesis
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2026Cell and Molecular Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 2021 - 2026View All Grants