Overview
Interested in the fascinating world of plants, microbes or inter-organismal communication and co-evolution? Please contact Prof. Sheng-Yang He (shengyang.he@duke.edu; hes@msu.edu).
Millions of years of co-evolution between plants and microbes have resulted in an intricate web of attack, counter-attack, decoy, and hijacking mechanisms in biology. Moreover, co-evolution between plants and microbes is greatly impacted by ongoing climate change. In our lab, we probe “host-microbe-climate” interactions to answer the following fundamental questions: (1) How do microbial pathogens infect a susceptible host? (2) How do plants select beneficial microbiomes to ensure health? (3) How do climate conditions impact disease and immunity?
We use contemporary methods to address these questions, including those commonly used in molecular genetics, genomics, biochemistry, cell biology, bioinformatics, microbiology, plant biology, co-evolution and infectious disease biology.
Current Appointments & Affiliations
Recent Publications
Aimea gen. nov. defines a novel plant-associated yeast genus in Microbotryomycetes with three novel species.
Journal Article bioRxiv · April 10, 2026 Plant tissues and surfaces are among the largest microbial habitats on Earth, and commensal yeasts are common members of these communities, where they can contribute to plant-microbe interactions including the biological control of plant diseases. Here, we ... Full text Link to item CiteMicrobial community succession and dynamics during the season-long development of apple fruit (<i>Malus</i> × <i>domestica</i>).
Journal Article Microbiology spectrum · April 2026 Microorganisms colonize every external and internal surface of plants, including fruits. Relatively little is known about the fruit microbiome and its role in disease resistance and fruit quality during fruit development and storage. The fruit tissue, the ... Full text CiteAn uORF-encoded mobile peptide sparks systemic stomatal immunity.
Journal Article Cell · March 2026 Higher organisms spread external stimuli from the perceptive tissues to the whole body to achieve systemic responses. In plants, guard cells sense pathogens and close stomata to prevent their entry. We observed that pathogen-infected local leaves transmit ... Full text CiteRecent Grants
Tri-Institutional Molecular Mycology and Pathogenesis Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029Establishment of an aqueous environment as a novel mechanism of bacterial pathogenesis
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2026Cell and Molecular Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 2021 - 2026View All Grants