Overview
Synthetic Virology & Gene Therapy
Current Appointments & Affiliations
Professor in Surgery
·
2019 - Present
Surgery, Surgical Sciences,
Surgery
Director of Gene Therapy
·
2018 - Present
Surgery, Surgical Sciences,
Surgery
Professor of Molecular Genetics and Microbiology
·
2019 - Present
Molecular Genetics and Microbiology,
Basic Science Departments
Professor of Biomedical Engineering
·
2019 - Present
Biomedical Engineering,
Pratt School of Engineering
Affiliate of the Duke Regeneration Center
·
2021 - Present
Duke Regeneration Center,
Basic Science Departments
Recent Publications
Rewriting Renal Fate: The Evolving Landscape of Adeno-Associated Virus-Mediated Kidney Gene Therapies.
Journal Article Kidney360 · December 24, 2025 Full text Link to item CiteComplete neutralizing antibody evasion by serodivergent non-mammalian AAVs enables gene therapy redosing.
Journal Article Cell Rep Med · December 16, 2025 The use of adeno-associated virus (AAV) as a gene therapy vector is significantly limited by pre-existing immunity. The high seroprevalence and broad antigenic cross-reactivity of primate-derived AAVs restrict patient eligibility and preclude therapeutic r ... Full text Link to item CiteEfficient kidney gene transfer and proximal tubule transduction using self-complementary AAV.cc47 vectors.
Journal Article Mol Ther Methods Clin Dev · December 11, 2025 Gene delivery to critical cell types within the kidney can enable preclinical evaluation of gene therapies for kidney disease. The novel adeno-associated virus AAV.cc47 was discovered after sequential evolution in mice, pigs, and macaques and improved tran ... Full text Link to item CiteRecent Grants
Interdisciplinary Research Training Program in AIDS
Inst. Training Prgm or CMEAdvisor · Awarded by National Institutes of Health · 2010 - 2030Kidney targeted AAV for gene therapy
ResearchPrincipal Investigator · Awarded by Vanderbilt University Medical Center · 2025 - 2030Immunomodulation in AAV gene therapy
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2029View All Grants
Education, Training & Certifications
University of North Carolina, Chapel Hill ·
2004
Ph.D.