Scholars@Duke
Christopher Bang Newgard

Christopher Bang Newgard

W. David and Sarah W. Stedman Distinguished Professor of Nutrition in the School of Medicine
Pharmacology & Cancer Biology
chris.newgard@duke.edu
Duke Box 104775, Durham, NC 27710
300 North Duke Street, Durham, NC 27701

Overview

Over its 16 year history, our laboratory has investigated mechanisms of metabolic regulation and fuel homeostasis in mammalian systems. Major projects include: 1) Mechanisms involved in regulation of insulin secretion from pancreatic islet β-cells by glucose and other metabolic fuels; 2) Development of methods for protection of β-cells against immune-mediated damage; 3) Studies on spatial organization and regulation of systems controlling hepatic glucose balance; 4) Studies on the mechanisms involved in lipid-induced impairment of insulin secretion and action in diabetes.

Current Appointments & Affiliations

W. David and Sarah W. Stedman Distinguished Professor of Nutrition in the School of Medicine · 2002 - Present Pharmacology & Cancer Biology, Basic Science Departments
Professor of Pharmacology and Cancer Biology · 2002 - Present Pharmacology & Cancer Biology, Basic Science Departments
Director, Sarah W. Stedman Nutrition and Metabolism Center · 2002 - Present Sarah Stedman Nutrition & Metabolism Center, Duke Molecular Physiology Institute
Professor in Medicine · 2020 - Present Medicine, Endocrinology, Metabolism, and Nutrition, Medicine
Member of the Duke Cancer Institute · 2002 - Present Duke Cancer Institute, Institutes and Centers
Affiliate, Duke Global Health Institute · 2009 - Present Duke Global Health Institute, University Institutes and Centers

In the News

Published August 13, 2024
New Use of an Old Hormone Leads to First Drug for a Type of Liver Disease
Published November 16, 2023
Which Duke Scholars Made the Most Cited List?
Published March 28, 2023
The Case of the Mysterious $11 Million Benefactor

View All News

Recent Publications

Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia.

Journal Article Nat Metab · December 2025 Understanding how cellular pathways interact is crucial for treating complex diseases like cancer. Individual gene-gene interaction studies have provided valuable insights, but may miss pathways working together. Here we develop a multi-gene approach to pa ... Full text Link to item Cite

Fiber Intervention Study in Prader-Willi Syndrome: Insights into Metabolic and Microbiota Shifts.

Journal Article J Clin Endocrinol Metab · October 16, 2025 CONTEXT: While increased fiber intake may benefit appetite and metabolism in the general population, its effects in individuals with Prader-Willi syndrome (PWS), a condition characterized by hyperphagia, obesity, and metabolic dysregulation, remain to be e ... Full text Link to item Cite

Dissecting the effect of mitochondrial BCAT inhibition in methylmalonic acidemia.

Journal Article JCI Insight · September 9, 2025 Methylmalonic acidemia (MMA) is a severe metabolic disorder affecting multiple organs because of a distal block in branched-chain amino acid (BCAA) catabolism. Standard of care is limited to protein restriction and supportive care during metabolic decompen ... Full text Link to item Cite
View All Publications

Recent Grants

Pharmacological Sciences Training Program

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2025 - 2030

Fibro/Adipogenic Progenitor Metabolic Reprogramming for Age-Related Muscle Fibrosis

ResearchMentor · Awarded by National Institute on Aging · 2024 - 2029

Endocrinology and Metabolism Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2024 - 2029

View All Grants

Education, Training & Certifications

University of Texas, Dallas · 1984 Ph.D.