https://orcid.org/0000-0002-0662-9921
Current Duke Appointments & Affiliations
George Barth Geller Distinguished Professor of Molecular Biology
·
2023 - Present
Biochemistry,
Basic Science Departments
Professor of Biochemistry
·
2020 - Present
Biochemistry,
Basic Science Departments
Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Professor in Neurobiology
·
2024 - Present
Neurobiology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2012 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Scholarly Works
Structural basis of fungal β-1,3-glucan synthase inhibition by caspofungin.
Journal article Nature · June 2026 Invasive fungal infections pose life-threatening risks to the increasing population of immunocompromised patients1,2. Treatment remains challenging due to limited antifungal drugs and increasing resistance. β-1,3-D-glucan synthase (GS), comprising the cata ... Full text Link to item CiteVisualizing insecticide control of insect TRP channel function and assembly.
Journal article Nat Commun · December 14, 2025 Insecticides are vital to combating world food shortages and transmission of vector-borne human diseases. Increasing insecticide resistance necessitates discovery of novel compounds against underutilized targets. Nanchung (Nan) and Inactive (Iav), the tran ... Full text Link to item CiteDesign, Synthesis, and Biological Evaluation of Lipid-Modified Derivatives of Tunicamycins.
Journal article Chemistry · October 22, 2025 Naturally occurring antibiotic tunicamycin targets bacterial peptidoglycan biosynthesis by inhibiting bacterial phospho-N-acetylmuraminic acid (MurNAc)-pentapeptide translocase (MraY), but it also inhibits human UDP-N-acetylglucosamine (GlcNAc): polyprenol ... Full text Link to item CiteRecent Grants
Structure, function, and pharmacology of sensory receptors
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2032Cell and Molecular Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 2026 - 2031Mechanisms of Action and Resistance of Antifungals Targeting Fungal beta-(1,3)-Glucan Synthase
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2026 - 2031View All Grants
Education
University of California, Berkeley ·
2003
Ph.D.
Yonsei University (South Korea) ·
1998
B.S.