Overview
Our research group is primarily interested in the study of respiratory RNA viruses. We have published work on viruses of the families: orthomyxoviridae, paramyxoviridae, and coronaviridae. The research in our laboratory is predominantly focused understanding the mechanisms of viral pathogenesis with the ultimate goal of developing new therapies that can be used to combat both current and future viral diseases.
Current Appointments & Affiliations
Professor of Molecular Genetics and Microbiology
·
2025 - Present
Molecular Genetics and Microbiology,
Basic Science Departments
Professor in Cell Biology
·
2025 - Present
Cell Biology,
Basic Science Departments
Professor in Integrative Immunobiology
·
2025 - Present
Integrative Immunobiology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2017 - Present
Duke Cancer Institute,
Institutes and Centers
Member of the Duke Human Vaccine Institute
·
2019 - Present
Duke Human Vaccine Institute,
Institutes and Centers
Recent Publications
Presentation of hemagglutinin on adjuvant-bearing self-assembling peptide nanofibers increases heterologous responses against influenza.
Journal Article Acta Biomater · January 2026 Influenza presents a global threat representing hundreds of thousands of deaths each year worldwide, yet influenza vaccines currently do not offer full protection against infection and must be updated each year to account for antigenic drift. Subunit vacci ... Full text Link to item CiteThe Shigella flexneri effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic bacteria against interferon-induced ubiquitylation.
Journal Article Elife · November 28, 2025 A central signal that marshals host defense against many infections is the lymphocyte-derived cytokine interferon-gamma (IFNγ). The IFNγ receptor is expressed on most human cells, and its activation leads to the expression of antimicrobial proteins that ex ... Full text Link to item CiteDevelopment of DNA and mRNA-LNP vaccines against an H5N1 clade 2.3.4.4b influenza virus.
Journal Article J Virol · August 19, 2025 UNLABELLED: Effective vaccines are an important public health tool which may be needed to combat the emerging, highly pathogenic H5N1 avian influenza viruses currently circulating in cattle and poultry in the United States. While nucleic acid-based vaccine ... Full text Link to item CiteRecent Grants
ETS-family Transcription Factor Mediated Control of Pulmonary Inflammation Induced by Influenza Viruses
ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2023 - 2028Ferroptosis and Ferroptotic Stress in Maladaptive Renal Repair - R01
ResearchCollaborator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2023 - 2028Control of virus induced type I interferon signaling during pregnancy
ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2022 - 2027View All Grants
Education, Training & Certifications
The University of Chicago ·
2012
Ph.D.