https://orcid.org/0000-0003-4541-5376
Overview
The Hirschey Lab in the Duke Molecular Physiology Institute, and the Departments of Medicine and Pharmacology & Cancer Biology at Duke University studies different aspects of metabolic control, mitochondrial signaling, and cellular processes regulating human health and disease.
Current Appointments & Affiliations
Associate Professor of Medicine
·
2019 - Present
Medicine, Endocrinology, Metabolism, and Nutrition,
Medicine
Associate Professor in Pharmacology and Cancer Biology
·
2019 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Associate Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Member of Sarah W. Stedman Nutrition and Metabolism Center
·
2011 - Present
Sarah Stedman Nutrition & Metabolism Center,
Duke Molecular Physiology Institute
Member of the Duke Cancer Institute
·
2012 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Caenorhabditis elegans fed native gut microbiota have altered bioenergetic pathway utilization impacting mitochondrial function and susceptibility to pollutants.
Journal Article Environ Sci Process Impacts · April 2, 2026 The gut microbiome can influence host health by facilitating digestion, immune function, and xenobiotic metabolism. Microbial metabolites can influence mitochondrial function by shifting bioenergetic pathways, potentially altering sensitivity to mitochondr ... Full text Link to item CiteIn vivo imaging of metabolic heterogeneity across three endpoints relevant to aggressive breast cancer.
Journal Article PNAS Nexus · March 2026 Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with poor prognosis and a high likelihood of recurrence. Residual disease after therapy is a key predictor of recurrence, often driven by intratumoral metabolic heterogeneity. A ... Full text Link to item Citedatadrivenhypothesis.org: A resource for metabolic gene discovery through integrated pathway co-essentiality mapping.
Journal Article bioRxiv · February 12, 2026 datadrivenhypothesis.org (DDH) integrates gene dependency, expression, literature data, and beyond from ~20,000 human genes to reveal hidden metabolic connections. Through pathway-level co-essentiality analysis with novelty scoring, DDH uncovered unexpecte ... Full text Link to item CiteRecent Grants
Pharmacological Sciences Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2025 - 2030Unified Program for Therapeutics in Children
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2025 - 2030Stimulating Access to Research in Residency (StARR) - NIAID
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of Allergy and Infectious Diseases · 2018 - 2029View All Grants
Education
University of California, Santa Barbara ·
2006
Ph.D.