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3D in vivo ARFI imaging: Prostate cancer sensitivity

Publication ,  Conference
Miller, ZA; Palmeri, ML; Rosenzweig, SJ; Glass, TJ; Nightingale, KR; Polascik, TJ; Buck, A; Madden, J
Published in: IEEE International Ultrasonics Symposium, IUS
October 20, 2014

Imaging tools that reliably visualize prostate cancer (PCa) are increasingly needed in the urological community. The objective of this research was to evaluate the ability of Acoustic Radiation Force Impulse (ARFI) imaging to localize PCa in 29 patients with biopsy-confirmed PCa who underwent radical prostatectomy and whole mount histopathology analysis. B-mode, ARFI imaging and whole mount histopathology volumes were acquired for each patient. Regions of suspicion (ROS) for PCa were reader-identified in ARFI images based on boundary delineation, contrast, texture and location, and compared to lesions identified in histopathology. ARFI imaging identified a total of 29 ROSs, 27 of which were correctly identified as cancer (PPV: 93%). ARFI imaging's overall sensitivity was 55%; however, there was significant variation in sensitivity depending on lesion type. We found that ARFI imaging was much more sensitive to posterior lesions (63%) than anterior lesions (12.5%). Posterior index lesions were identified with greater sensitivity (81%) than clinically-insignificant lesions (33%).

Duke Scholars

Published In

IEEE International Ultrasonics Symposium, IUS

DOI

EISSN

1948-5727

ISSN

1948-5719

ISBN

9781479970490

Publication Date

October 20, 2014

Start / End Page

209 / 212
 

Citation

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Miller, Z. A., Palmeri, M. L., Rosenzweig, S. J., Glass, T. J., Nightingale, K. R., Polascik, T. J., … Madden, J. (2014). 3D in vivo ARFI imaging: Prostate cancer sensitivity. In IEEE International Ultrasonics Symposium, IUS (pp. 209–212). https://doi.org/10.1109/ULTSYM.2014.0053
Miller, Z. A., M. L. Palmeri, S. J. Rosenzweig, T. J. Glass, K. R. Nightingale, T. J. Polascik, A. Buck, and J. Madden. “3D in vivo ARFI imaging: Prostate cancer sensitivity.” In IEEE International Ultrasonics Symposium, IUS, 209–12, 2014. https://doi.org/10.1109/ULTSYM.2014.0053.
Miller ZA, Palmeri ML, Rosenzweig SJ, Glass TJ, Nightingale KR, Polascik TJ, et al. 3D in vivo ARFI imaging: Prostate cancer sensitivity. In: IEEE International Ultrasonics Symposium, IUS. 2014. p. 209–12.
Miller, Z. A., et al. “3D in vivo ARFI imaging: Prostate cancer sensitivity.” IEEE International Ultrasonics Symposium, IUS, 2014, pp. 209–12. Scopus, doi:10.1109/ULTSYM.2014.0053.
Miller ZA, Palmeri ML, Rosenzweig SJ, Glass TJ, Nightingale KR, Polascik TJ, Buck A, Madden J. 3D in vivo ARFI imaging: Prostate cancer sensitivity. IEEE International Ultrasonics Symposium, IUS. 2014. p. 209–212.

Published In

IEEE International Ultrasonics Symposium, IUS

DOI

EISSN

1948-5727

ISSN

1948-5719

ISBN

9781479970490

Publication Date

October 20, 2014

Start / End Page

209 / 212