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Microtesla SABRE enables 10% nitrogen-15 nuclear spin polarization.

Publication ,  Journal Article
Theis, T; Truong, ML; Coffey, AM; Shchepin, RV; Waddell, KW; Shi, F; Goodson, BM; Warren, WS; Chekmenev, EY
Published in: Journal of the American Chemical Society
February 2015

Parahydrogen is demonstrated to efficiently transfer its nuclear spin hyperpolarization to nitrogen-15 in pyridine and nicotinamide (vitamin B(3) amide) by conducting "signal amplification by reversible exchange" (SABRE) at microtesla fields within a magnetic shield. Following transfer of the sample from the magnetic shield chamber to a conventional NMR spectrometer, the (15)N NMR signals for these molecules are enhanced by ∼30,000- and ∼20,000-fold at 9.4 T, corresponding to ∼10% and ∼7% nuclear spin polarization, respectively. This method, dubbed "SABRE in shield enables alignment transfer to heteronuclei" or "SABRE-SHEATH", promises to be a simple, cost-effective way to hyperpolarize heteronuclei. It may be particularly useful for in vivo applications because of longer hyperpolarization lifetimes, lack of background signal, and facile chemical-shift discrimination of different species.

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Published In

Journal of the American Chemical Society

DOI

EISSN

1520-5126

ISSN

0002-7863

Publication Date

February 2015

Volume

137

Issue

4

Start / End Page

1404 / 1407

Related Subject Headings

  • Pyridines
  • Nitrogen Isotopes
  • Niacinamide
  • Models, Molecular
  • Magnetic Resonance Spectroscopy
  • Hydrogen
  • General Chemistry
  • 40 Engineering
  • 34 Chemical sciences
  • 03 Chemical Sciences
 

Citation

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Theis, T., Truong, M. L., Coffey, A. M., Shchepin, R. V., Waddell, K. W., Shi, F., … Chekmenev, E. Y. (2015). Microtesla SABRE enables 10% nitrogen-15 nuclear spin polarization. Journal of the American Chemical Society, 137(4), 1404–1407. https://doi.org/10.1021/ja512242d
Theis, Thomas, Milton L. Truong, Aaron M. Coffey, Roman V. Shchepin, Kevin W. Waddell, Fan Shi, Boyd M. Goodson, Warren S. Warren, and Eduard Y. Chekmenev. “Microtesla SABRE enables 10% nitrogen-15 nuclear spin polarization.Journal of the American Chemical Society 137, no. 4 (February 2015): 1404–7. https://doi.org/10.1021/ja512242d.
Theis T, Truong ML, Coffey AM, Shchepin RV, Waddell KW, Shi F, et al. Microtesla SABRE enables 10% nitrogen-15 nuclear spin polarization. Journal of the American Chemical Society. 2015 Feb;137(4):1404–7.
Theis, Thomas, et al. “Microtesla SABRE enables 10% nitrogen-15 nuclear spin polarization.Journal of the American Chemical Society, vol. 137, no. 4, Feb. 2015, pp. 1404–07. Epmc, doi:10.1021/ja512242d.
Theis T, Truong ML, Coffey AM, Shchepin RV, Waddell KW, Shi F, Goodson BM, Warren WS, Chekmenev EY. Microtesla SABRE enables 10% nitrogen-15 nuclear spin polarization. Journal of the American Chemical Society. 2015 Feb;137(4):1404–1407.
Journal cover image

Published In

Journal of the American Chemical Society

DOI

EISSN

1520-5126

ISSN

0002-7863

Publication Date

February 2015

Volume

137

Issue

4

Start / End Page

1404 / 1407

Related Subject Headings

  • Pyridines
  • Nitrogen Isotopes
  • Niacinamide
  • Models, Molecular
  • Magnetic Resonance Spectroscopy
  • Hydrogen
  • General Chemistry
  • 40 Engineering
  • 34 Chemical sciences
  • 03 Chemical Sciences