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Microtesla SABRE enables 10% nitrogen-15 nuclear spin polarization.

Publication ,  Journal Article
Theis, T; Truong, ML; Coffey, AM; Shchepin, RV; Waddell, KW; Shi, F; Goodson, BM; Warren, WS; Chekmenev, EY
Published in: Journal of the American Chemical Society
February 2015

Parahydrogen is demonstrated to efficiently transfer its nuclear spin hyperpolarization to nitrogen-15 in pyridine and nicotinamide (vitamin B(3) amide) by conducting "signal amplification by reversible exchange" (SABRE) at microtesla fields within a magnetic shield. Following transfer of the sample from the magnetic shield chamber to a conventional NMR spectrometer, the (15)N NMR signals for these molecules are enhanced by ∼30,000- and ∼20,000-fold at 9.4 T, corresponding to ∼10% and ∼7% nuclear spin polarization, respectively. This method, dubbed "SABRE in shield enables alignment transfer to heteronuclei" or "SABRE-SHEATH", promises to be a simple, cost-effective way to hyperpolarize heteronuclei. It may be particularly useful for in vivo applications because of longer hyperpolarization lifetimes, lack of background signal, and facile chemical-shift discrimination of different species.

Duke Scholars

Published In

Journal of the American Chemical Society

DOI

EISSN

1520-5126

ISSN

0002-7863

Publication Date

February 2015

Volume

137

Issue

4

Start / End Page

1404 / 1407

Related Subject Headings

  • Pyridines
  • Nitrogen Isotopes
  • Niacinamide
  • Models, Molecular
  • Magnetic Resonance Spectroscopy
  • Hydrogen
  • General Chemistry
  • 40 Engineering
  • 34 Chemical sciences
  • 03 Chemical Sciences
 

Citation

APA
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ICMJE
MLA
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Theis, T., Truong, M. L., Coffey, A. M., Shchepin, R. V., Waddell, K. W., Shi, F., … Chekmenev, E. Y. (2015). Microtesla SABRE enables 10% nitrogen-15 nuclear spin polarization. Journal of the American Chemical Society, 137(4), 1404–1407. https://doi.org/10.1021/ja512242d
Journal cover image

Published In

Journal of the American Chemical Society

DOI

EISSN

1520-5126

ISSN

0002-7863

Publication Date

February 2015

Volume

137

Issue

4

Start / End Page

1404 / 1407

Related Subject Headings

  • Pyridines
  • Nitrogen Isotopes
  • Niacinamide
  • Models, Molecular
  • Magnetic Resonance Spectroscopy
  • Hydrogen
  • General Chemistry
  • 40 Engineering
  • 34 Chemical sciences
  • 03 Chemical Sciences