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Doxorubicin-conjugated polypeptide nanoparticles inhibit metastasis in two murine models of carcinoma.

Publication ,  Journal Article
Mastria, EM; Chen, M; McDaniel, JR; Li, X; Hyun, J; Dewhirst, MW; Chilkoti, A
Published in: J Control Release
June 28, 2015

Drug delivery vehicles are often assessed for their ability to control primary tumor growth, but the outcome of cancer treatment depends on controlling or inhibiting metastasis. Therefore, we studied the efficacy of our genetically encoded polypeptide nanoparticle for doxorubicin delivery (CP-Dox) in the syngeneic metastatic murine models 4T1 and Lewis lung carcinoma. We found that our nanoparticle formulation increased the half-life, maximum tolerated dose, and tumor accumulation of doxorubicin. When drug treatment was combined with primary tumor resection, greater than 60% of the mice were cured in both the 4T1 and Lewis lung carcinoma models compared to 20% treated with free drug. Mechanistic studies suggest that metastasis inhibition and survival increase were achieved by preventing the dissemination of viable tumor cells from the primary tumor.

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Published In

J Control Release

DOI

EISSN

1873-4995

Publication Date

June 28, 2015

Volume

208

Start / End Page

52 / 58

Location

Netherlands

Related Subject Headings

  • Tissue Distribution
  • Survival Analysis
  • Pharmacology & Pharmacy
  • Peptides
  • Neoplasms, Experimental
  • Neoplasm Metastasis
  • Nanoparticles
  • Mice, Inbred BALB C
  • Mice
  • Maximum Tolerated Dose
 

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Mastria, E. M., Chen, M., McDaniel, J. R., Li, X., Hyun, J., Dewhirst, M. W., & Chilkoti, A. (2015). Doxorubicin-conjugated polypeptide nanoparticles inhibit metastasis in two murine models of carcinoma. J Control Release, 208, 52–58. https://doi.org/10.1016/j.jconrel.2015.01.033
Mastria, Eric M., Mingnan Chen, Jonathan R. McDaniel, Xinghai Li, Jinho Hyun, Mark W. Dewhirst, and Ashutosh Chilkoti. “Doxorubicin-conjugated polypeptide nanoparticles inhibit metastasis in two murine models of carcinoma.J Control Release 208 (June 28, 2015): 52–58. https://doi.org/10.1016/j.jconrel.2015.01.033.
Mastria EM, Chen M, McDaniel JR, Li X, Hyun J, Dewhirst MW, et al. Doxorubicin-conjugated polypeptide nanoparticles inhibit metastasis in two murine models of carcinoma. J Control Release. 2015 Jun 28;208:52–8.
Mastria, Eric M., et al. “Doxorubicin-conjugated polypeptide nanoparticles inhibit metastasis in two murine models of carcinoma.J Control Release, vol. 208, June 2015, pp. 52–58. Pubmed, doi:10.1016/j.jconrel.2015.01.033.
Mastria EM, Chen M, McDaniel JR, Li X, Hyun J, Dewhirst MW, Chilkoti A. Doxorubicin-conjugated polypeptide nanoparticles inhibit metastasis in two murine models of carcinoma. J Control Release. 2015 Jun 28;208:52–58.
Journal cover image

Published In

J Control Release

DOI

EISSN

1873-4995

Publication Date

June 28, 2015

Volume

208

Start / End Page

52 / 58

Location

Netherlands

Related Subject Headings

  • Tissue Distribution
  • Survival Analysis
  • Pharmacology & Pharmacy
  • Peptides
  • Neoplasms, Experimental
  • Neoplasm Metastasis
  • Nanoparticles
  • Mice, Inbred BALB C
  • Mice
  • Maximum Tolerated Dose