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Antibodies for prevention of mother-to-child transmission of HIV-1.

Publication ,  Journal Article
Fouda, GG; Moody, MA; Permar, SR
Published in: Curr Opin HIV AIDS
May 2015

PURPOSE OF REVIEW: Although antiretroviral (ARV) prophylaxis can reduce mother-to-child transmission (MTCT) of HIV-1 to less than 2%, one-quarter of a million infants continue to be infected with HIV-1 annually. ARV prophylaxis alone will fail to eliminate infant HIV-1 infection because of issues of maternal adherence, toxicities, ARV-resistant virus strains, and acute maternal infection. Effective maternal and/or infant immunization will likely be required to achieve the goal of an HIV-free generation. RECENT FINDINGS: This article describes recent studies of antibody responses that protect against vertical HIV-1 transmission. Studies have shown that maternal neutralization breadth is not a critical factor in MTCT, yet the ability of maternal plasma to neutralize autologous virus variants may be important in infant protection. There is also new evidence that infants mount robust and durable antibody responses to HIV-1 envelope following vaccination and can develop broad neutralization during infection. Finally, passive immunization of infants with highly potent and broad neutralizing antibodies may be an effective strategy to protect infants against infection with postnatally transmitted variants. SUMMARY: Defining the characteristics of maternal and infant antibody responses that protect against MTCT will inform development of effective passive and active immunization strategies that will likely be required to eliminate pediatric HIV-1.

Duke Scholars

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Published In

Curr Opin HIV AIDS

DOI

EISSN

1746-6318

Publication Date

May 2015

Volume

10

Issue

3

Start / End Page

177 / 182

Location

United States

Related Subject Headings

  • Virology
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Infectious Disease Transmission, Vertical
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • Female
  • 4202 Epidemiology
 

Citation

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ICMJE
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Fouda, G. G., Moody, M. A., & Permar, S. R. (2015). Antibodies for prevention of mother-to-child transmission of HIV-1. Curr Opin HIV AIDS, 10(3), 177–182. https://doi.org/10.1097/COH.0000000000000150
Fouda, Genevieve G., M Anthony Moody, and Sallie R. Permar. “Antibodies for prevention of mother-to-child transmission of HIV-1.Curr Opin HIV AIDS 10, no. 3 (May 2015): 177–82. https://doi.org/10.1097/COH.0000000000000150.
Fouda GG, Moody MA, Permar SR. Antibodies for prevention of mother-to-child transmission of HIV-1. Curr Opin HIV AIDS. 2015 May;10(3):177–82.
Fouda, Genevieve G., et al. “Antibodies for prevention of mother-to-child transmission of HIV-1.Curr Opin HIV AIDS, vol. 10, no. 3, May 2015, pp. 177–82. Pubmed, doi:10.1097/COH.0000000000000150.
Fouda GG, Moody MA, Permar SR. Antibodies for prevention of mother-to-child transmission of HIV-1. Curr Opin HIV AIDS. 2015 May;10(3):177–182.

Published In

Curr Opin HIV AIDS

DOI

EISSN

1746-6318

Publication Date

May 2015

Volume

10

Issue

3

Start / End Page

177 / 182

Location

United States

Related Subject Headings

  • Virology
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Infectious Disease Transmission, Vertical
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • Female
  • 4202 Epidemiology