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Persisting effects of a PBDE metabolite, 6-OH-BDE-47, on larval and juvenile zebrafish swimming behavior.

Publication ,  Journal Article
Macaulay, LJ; Bailey, JM; Levin, ED; Stapleton, HM
Published in: Neurotoxicol Teratol
2015

Polybrominated diphenyl ethers (PBDEs) are persistent organic pollutants that are widely detected in the environment, biota, and humans. In mammals, PBDEs can be oxidatively metabolized to form hydroxylated polybrominated diphenyl ethers (OH-BDEs). While studies have examined behavioral deficits or alterations induced by exposure to PBDEs in both rodents and fish, no study to date has explored behavioral effects from exposure to OH-BDEs, which have been shown to have greater endocrine disrupting potential compared to PBDEs. In the present study, zebrafish (Danio rerio) were exposed during embryonic and larval development (0-6 days post fertilization, dpf) to a PBDE metabolite, 6-hydroxy, 2,2',4,4' tetrabromodiphenyl ether (10-50 nM) and then examined for short and long-term behavioral effects. Exposed zebrafish tested as larvae (6 dpf) showed an altered swimming response to light-dark transitions, exhibiting hypoactivity in light periods compared to control fish. When fish exposed from 0-6 dpf were tested as juveniles (45 dpf), they showed an increased fear response and hyperactivity in response to tests of novel environment exploration and habituation learning. These results demonstrate that early life exposure to a PBDE metabolite can have immediate or later life (more than a month after exposure) effects on activity levels, habituation, and fear/anxiety.

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Published In

Neurotoxicol Teratol

DOI

EISSN

1872-9738

Publication Date

2015

Volume

52

Issue

Pt B

Start / End Page

119 / 126

Location

United States

Related Subject Headings

  • Zebrafish
  • Toxicology
  • Swimming
  • Reflex, Startle
  • Polybrominated Biphenyls
  • Photoperiod
  • Motor Activity
  • Halogenated Diphenyl Ethers
  • Flame Retardants
  • Fear
 

Citation

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Macaulay, L. J., Bailey, J. M., Levin, E. D., & Stapleton, H. M. (2015). Persisting effects of a PBDE metabolite, 6-OH-BDE-47, on larval and juvenile zebrafish swimming behavior. Neurotoxicol Teratol, 52(Pt B), 119–126. https://doi.org/10.1016/j.ntt.2015.05.002
Macaulay, Laura J., Jordan M. Bailey, Edward D. Levin, and Heather M. Stapleton. “Persisting effects of a PBDE metabolite, 6-OH-BDE-47, on larval and juvenile zebrafish swimming behavior.Neurotoxicol Teratol 52, no. Pt B (2015): 119–26. https://doi.org/10.1016/j.ntt.2015.05.002.
Macaulay LJ, Bailey JM, Levin ED, Stapleton HM. Persisting effects of a PBDE metabolite, 6-OH-BDE-47, on larval and juvenile zebrafish swimming behavior. Neurotoxicol Teratol. 2015;52(Pt B):119–26.
Macaulay, Laura J., et al. “Persisting effects of a PBDE metabolite, 6-OH-BDE-47, on larval and juvenile zebrafish swimming behavior.Neurotoxicol Teratol, vol. 52, no. Pt B, 2015, pp. 119–26. Pubmed, doi:10.1016/j.ntt.2015.05.002.
Macaulay LJ, Bailey JM, Levin ED, Stapleton HM. Persisting effects of a PBDE metabolite, 6-OH-BDE-47, on larval and juvenile zebrafish swimming behavior. Neurotoxicol Teratol. 2015;52(Pt B):119–126.
Journal cover image

Published In

Neurotoxicol Teratol

DOI

EISSN

1872-9738

Publication Date

2015

Volume

52

Issue

Pt B

Start / End Page

119 / 126

Location

United States

Related Subject Headings

  • Zebrafish
  • Toxicology
  • Swimming
  • Reflex, Startle
  • Polybrominated Biphenyls
  • Photoperiod
  • Motor Activity
  • Halogenated Diphenyl Ethers
  • Flame Retardants
  • Fear