Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management.
Staphylococcus aureus is a major human pathogen that causes a wide range of clinical infections. It is a leading cause of bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device-related infections. This review comprehensively covers the epidemiology, pathophysiology, clinical manifestations, and management of each of these clinical entities. The past 2 decades have witnessed two clear shifts in the epidemiology of S. aureus infections: first, a growing number of health care-associated infections, particularly seen in infective endocarditis and prosthetic device infections, and second, an epidemic of community-associated skin and soft tissue infections driven by strains with certain virulence factors and resistance to β-lactam antibiotics. In reviewing the literature to support management strategies for these clinical manifestations, we also highlight the paucity of high-quality evidence for many key clinical questions.
Duke Scholars
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Related Subject Headings
- beta-Lactam Resistance
- Virulence Factors
- Staphylococcus aureus
- Staphylococcal Infections
- Risk Factors
- Prosthesis-Related Infections
- Microbiology
- Humans
- Cross Infection
- Community-Acquired Infections
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- beta-Lactam Resistance
- Virulence Factors
- Staphylococcus aureus
- Staphylococcal Infections
- Risk Factors
- Prosthesis-Related Infections
- Microbiology
- Humans
- Cross Infection
- Community-Acquired Infections