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Posterior Eye Shape Measurement With Retinal OCT Compared to MRI.

Publication ,  Journal Article
Kuo, AN; Verkicharla, PK; McNabb, RP; Cheung, CY; Hilal, S; Farsiu, S; Chen, C; Wong, TY; Ikram, MK; Cheng, CY; Young, TL; Saw, SM; Izatt, JA
Published in: Invest Ophthalmol Vis Sci
July 1, 2016

PURPOSE: Posterior eye shape assessment by magnetic resonance imaging (MRI) is used to study myopia. We tested the hypothesis that optical coherence tomography (OCT), as an alternative, could measure posterior eye shape similarly to MRI. METHODS: Macular spectral-domain OCT and brain MRI images previously acquired as part of the Singapore Epidemiology of Eye Diseases study were analyzed. The right eye in the MRI and OCT images was automatically segmented. Optical coherence tomography segmentations were corrected for optical and display distortions requiring biometry data. The segmentations were fitted to spheres and ellipsoids to obtain the posterior eye radius of curvature (Rc) and asphericity (Qxz). The differences in Rc and Qxz measured by MRI and OCT were tested using paired t-tests. Categorical assignments of prolateness or oblateness using Qxz were compared. RESULTS: Fifty-two subjects (67.8 ± 5.6 years old) with spherical equivalent refraction from +0.50 to -5.38 were included. The mean paired difference between MRI and original OCT posterior eye Rc was 24.03 ± 46.49 mm (P = 0.0005). For corrected OCT images, the difference in Rc decreased to -0.23 ± 2.47 mm (P = 0.51). The difference between MRI and OCT asphericity, Qxz, was -0.052 ± 0.343 (P = 0.28). However, categorical agreement was only moderate (κ = 0.50). CONCLUSIONS: Distortion-corrected OCT measurements of Rc and Qxz were not statistically significantly different from MRI, although the moderate categorical agreement suggests that individual differences remained. This study provides evidence that with distortion correction, noninvasive office-based OCT could potentially be used instead of MRI for the study of posterior eye shape.

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Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

July 1, 2016

Volume

57

Issue

9

Start / End Page

OCT196 / OCT203

Location

United States

Related Subject Headings

  • Tomography, Optical Coherence
  • Singapore
  • Retina
  • Posterior Eye Segment
  • Ophthalmology & Optometry
  • Myopia
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Incidence
 

Citation

APA
Chicago
ICMJE
MLA
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Kuo, A. N., Verkicharla, P. K., McNabb, R. P., Cheung, C. Y., Hilal, S., Farsiu, S., … Izatt, J. A. (2016). Posterior Eye Shape Measurement With Retinal OCT Compared to MRI. Invest Ophthalmol Vis Sci, 57(9), OCT196–OCT203. https://doi.org/10.1167/iovs.15-18886
Kuo, Anthony N., Pavan K. Verkicharla, Ryan P. McNabb, Carol Y. Cheung, Saima Hilal, Sina Farsiu, Christopher Chen, et al. “Posterior Eye Shape Measurement With Retinal OCT Compared to MRI.Invest Ophthalmol Vis Sci 57, no. 9 (July 1, 2016): OCT196–203. https://doi.org/10.1167/iovs.15-18886.
Kuo AN, Verkicharla PK, McNabb RP, Cheung CY, Hilal S, Farsiu S, et al. Posterior Eye Shape Measurement With Retinal OCT Compared to MRI. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT196–203.
Kuo, Anthony N., et al. “Posterior Eye Shape Measurement With Retinal OCT Compared to MRI.Invest Ophthalmol Vis Sci, vol. 57, no. 9, July 2016, pp. OCT196–203. Pubmed, doi:10.1167/iovs.15-18886.
Kuo AN, Verkicharla PK, McNabb RP, Cheung CY, Hilal S, Farsiu S, Chen C, Wong TY, Ikram MK, Cheng CY, Young TL, Saw SM, Izatt JA. Posterior Eye Shape Measurement With Retinal OCT Compared to MRI. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT196–OCT203.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

July 1, 2016

Volume

57

Issue

9

Start / End Page

OCT196 / OCT203

Location

United States

Related Subject Headings

  • Tomography, Optical Coherence
  • Singapore
  • Retina
  • Posterior Eye Segment
  • Ophthalmology & Optometry
  • Myopia
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Incidence