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Different lines of rats selectively-bred for high alcohol-drinking demonstrate disparate preferences for nicotine self-administration

Publication ,  Journal Article
Rezvani, AH; Levin, ED; Wells, C; Slade, S; Morrison, M; Marshall, L; Morris, M; Confino, J; Allenby, C; Lumeng, L
Published in: Journal of Drug and Alcohol Research
January 1, 2016

Background. Alcohol and nicotine are commonly coabused. The search for a common core of neural, behavioral, and genetic factors underlying addiction has been the goal of addiction research. Purpose. Genetic predisposition to high alcohol intake has been studied in rats by selectively breeding rats that have high preference for alcohol. The current experiments were conducted to determine if the level of intravenous nicotine administration for the various lines of alcohol-preferring rats differs from that for nonalcohol-preferring controls. Study design. Adult alcohol-naïve selectively-bred alcohol-preferring male rats from four lines (P, AA, HAD-1, sP) and their control nonalcohol-preferring rats (NP, ANA, LAD-1, sNP) were trained and given access to self-administer nicotine (0.03mg/kg/infusion). Results. The results show that the P rats selfadministered significantly more nicotine than NP rats. In contrast, there were no significant differences in nicotine self-administration between the sP and sNP or the AA and ANA rats. Unexpectedly, high alcohol-drinking HAD-1 rats self-administered significantly less nicotine than low alcohol-drinking LAD-1 rats. Conclusion. This suggests that some genetic factors that underlie high-alcohol intake have more general effects in promoting high nicotine intake tendencies, while other genetic factors are more specific to only heavy drinking.

Duke Scholars

Published In

Journal of Drug and Alcohol Research

DOI

EISSN

2090-8342

ISSN

2090-8334

Publication Date

January 1, 2016

Volume

2016

Issue

5

Related Subject Headings

  • 3214 Pharmacology and pharmaceutical sciences
 

Citation

APA
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ICMJE
MLA
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Rezvani, A. H., Levin, E. D., Wells, C., Slade, S., Morrison, M., Marshall, L., … Lumeng, L. (2016). Different lines of rats selectively-bred for high alcohol-drinking demonstrate disparate preferences for nicotine self-administration. Journal of Drug and Alcohol Research, 2016(5). https://doi.org/10.4303/jdar/235972
Rezvani, A. H., E. D. Levin, C. Wells, S. Slade, M. Morrison, L. Marshall, M. Morris, J. Confino, C. Allenby, and L. Lumeng. “Different lines of rats selectively-bred for high alcohol-drinking demonstrate disparate preferences for nicotine self-administration.” Journal of Drug and Alcohol Research 2016, no. 5 (January 1, 2016). https://doi.org/10.4303/jdar/235972.
Rezvani AH, Levin ED, Wells C, Slade S, Morrison M, Marshall L, et al. Different lines of rats selectively-bred for high alcohol-drinking demonstrate disparate preferences for nicotine self-administration. Journal of Drug and Alcohol Research. 2016 Jan 1;2016(5).
Rezvani, A. H., et al. “Different lines of rats selectively-bred for high alcohol-drinking demonstrate disparate preferences for nicotine self-administration.” Journal of Drug and Alcohol Research, vol. 2016, no. 5, Jan. 2016. Scopus, doi:10.4303/jdar/235972.
Rezvani AH, Levin ED, Wells C, Slade S, Morrison M, Marshall L, Morris M, Confino J, Allenby C, Lumeng L. Different lines of rats selectively-bred for high alcohol-drinking demonstrate disparate preferences for nicotine self-administration. Journal of Drug and Alcohol Research. 2016 Jan 1;2016(5).

Published In

Journal of Drug and Alcohol Research

DOI

EISSN

2090-8342

ISSN

2090-8334

Publication Date

January 1, 2016

Volume

2016

Issue

5

Related Subject Headings

  • 3214 Pharmacology and pharmaceutical sciences