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Segmentation guided registration of wide field-of-view retinal optical coherence tomography volumes.

Publication ,  Journal Article
Lezama, J; Mukherjee, D; McNabb, RP; Sapiro, G; Kuo, AN; Farsiu, S
Published in: Biomed Opt Express
December 1, 2016

Patient motion artifacts are often visible in densely sampled or large wide field-of-view (FOV) retinal optical coherence tomography (OCT) volumes. A popular strategy for reducing motion artifacts is to capture two orthogonally oriented volumetric scans. However, due to larger volume sizes, longer acquisition times, and corresponding larger motion artifacts, the registration of wide FOV scans remains a challenging problem. In particular, gaps in data acquisition due to eye motion, such as saccades, can be significant and their modeling becomes critical for successful registration. In this article, we develop a complete computational pipeline for the automatic motion correction and accurate registration of wide FOV orthogonally scanned OCT images of the human retina. The proposed framework utilizes the retinal boundary segmentation as a guide for registration and requires only a minimal transformation of the acquired data to produce a successful registration. It includes saccade detection and correction, a custom version of the optical flow algorithm for dense lateral registration and a linear optimization approach for axial registration. Utilizing a wide FOV swept source OCT system, we acquired retinal volumes of 12 subjects and we provide qualitative and quantitative experimental results to validate the state-of-the-art effectiveness of the proposed technique. The source code corresponding to the proposed algorithm is available online.

Duke Scholars

Published In

Biomed Opt Express

DOI

ISSN

2156-7085

Publication Date

December 1, 2016

Volume

7

Issue

12

Start / End Page

4827 / 4846

Location

United States

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4003 Biomedical engineering
  • 3212 Ophthalmology and optometry
  • 0912 Materials Engineering
  • 0205 Optical Physics
 

Citation

APA
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ICMJE
MLA
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Lezama, J., Mukherjee, D., McNabb, R. P., Sapiro, G., Kuo, A. N., & Farsiu, S. (2016). Segmentation guided registration of wide field-of-view retinal optical coherence tomography volumes. Biomed Opt Express, 7(12), 4827–4846. https://doi.org/10.1364/BOE.7.004827
Lezama, José, Dibyendu Mukherjee, Ryan P. McNabb, Guillermo Sapiro, Anthony N. Kuo, and Sina Farsiu. “Segmentation guided registration of wide field-of-view retinal optical coherence tomography volumes.Biomed Opt Express 7, no. 12 (December 1, 2016): 4827–46. https://doi.org/10.1364/BOE.7.004827.
Lezama J, Mukherjee D, McNabb RP, Sapiro G, Kuo AN, Farsiu S. Segmentation guided registration of wide field-of-view retinal optical coherence tomography volumes. Biomed Opt Express. 2016 Dec 1;7(12):4827–46.
Lezama, José, et al. “Segmentation guided registration of wide field-of-view retinal optical coherence tomography volumes.Biomed Opt Express, vol. 7, no. 12, Dec. 2016, pp. 4827–46. Pubmed, doi:10.1364/BOE.7.004827.
Lezama J, Mukherjee D, McNabb RP, Sapiro G, Kuo AN, Farsiu S. Segmentation guided registration of wide field-of-view retinal optical coherence tomography volumes. Biomed Opt Express. 2016 Dec 1;7(12):4827–4846.
Journal cover image

Published In

Biomed Opt Express

DOI

ISSN

2156-7085

Publication Date

December 1, 2016

Volume

7

Issue

12

Start / End Page

4827 / 4846

Location

United States

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4003 Biomedical engineering
  • 3212 Ophthalmology and optometry
  • 0912 Materials Engineering
  • 0205 Optical Physics