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A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy.

Publication ,  Journal Article
Ruas, JL; White, JP; Rao, RR; Kleiner, S; Brannan, KT; Harrison, BC; Greene, NP; Wu, J; Estall, JL; Irving, BA; Lanza, IR; Rasbach, KA ...
Published in: Cell
December 7, 2012

PGC-1α is a transcriptional coactivator induced by exercise that gives muscle many of the best known adaptations to endurance-type exercise but has no effects on muscle strength or hypertrophy. We have identified a form of PGC-1α (PGC-1α4) that results from alternative promoter usage and splicing of the primary transcript. PGC-1α4 is highly expressed in exercised muscle but does not regulate most known PGC-1α targets such as the mitochondrial OXPHOS genes. Rather, it specifically induces IGF1 and represses myostatin, and expression of PGC-1α4 in vitro and in vivo induces robust skeletal muscle hypertrophy. Importantly, mice with skeletal muscle-specific transgenic expression of PGC-1α4 show increased muscle mass and strength and dramatic resistance to the muscle wasting of cancer cachexia. Expression of PGC-1α4 is preferentially induced in mouse and human muscle during resistance exercise. These studies identify a PGC-1α protein that regulates and coordinates factors involved in skeletal muscle hypertrophy.

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Published In

Cell

DOI

EISSN

1097-4172

Publication Date

December 7, 2012

Volume

151

Issue

6

Start / End Page

1319 / 1331

Location

United States

Related Subject Headings

  • Transcription Factors
  • Trans-Activators
  • Resistance Training
  • Protein Isoforms
  • Physical Conditioning, Animal
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • Myostatin
  • Muscle, Skeletal
  • Muscle Fibers, Skeletal
  • Molecular Sequence Data
 

Citation

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Ruas, J. L., White, J. P., Rao, R. R., Kleiner, S., Brannan, K. T., Harrison, B. C., … Spiegelman, B. M. (2012). A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell, 151(6), 1319–1331. https://doi.org/10.1016/j.cell.2012.10.050
Ruas, Jorge L., James P. White, Rajesh R. Rao, Sandra Kleiner, Kevin T. Brannan, Brooke C. Harrison, Nicholas P. Greene, et al. “A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy.Cell 151, no. 6 (December 7, 2012): 1319–31. https://doi.org/10.1016/j.cell.2012.10.050.
Ruas JL, White JP, Rao RR, Kleiner S, Brannan KT, Harrison BC, et al. A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell. 2012 Dec 7;151(6):1319–31.
Ruas, Jorge L., et al. “A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy.Cell, vol. 151, no. 6, Dec. 2012, pp. 1319–31. Pubmed, doi:10.1016/j.cell.2012.10.050.
Ruas JL, White JP, Rao RR, Kleiner S, Brannan KT, Harrison BC, Greene NP, Wu J, Estall JL, Irving BA, Lanza IR, Rasbach KA, Okutsu M, Nair KS, Yan Z, Leinwand LA, Spiegelman BM. A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell. 2012 Dec 7;151(6):1319–1331.
Journal cover image

Published In

Cell

DOI

EISSN

1097-4172

Publication Date

December 7, 2012

Volume

151

Issue

6

Start / End Page

1319 / 1331

Location

United States

Related Subject Headings

  • Transcription Factors
  • Trans-Activators
  • Resistance Training
  • Protein Isoforms
  • Physical Conditioning, Animal
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • Myostatin
  • Muscle, Skeletal
  • Muscle Fibers, Skeletal
  • Molecular Sequence Data