
A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy.
PGC-1α is a transcriptional coactivator induced by exercise that gives muscle many of the best known adaptations to endurance-type exercise but has no effects on muscle strength or hypertrophy. We have identified a form of PGC-1α (PGC-1α4) that results from alternative promoter usage and splicing of the primary transcript. PGC-1α4 is highly expressed in exercised muscle but does not regulate most known PGC-1α targets such as the mitochondrial OXPHOS genes. Rather, it specifically induces IGF1 and represses myostatin, and expression of PGC-1α4 in vitro and in vivo induces robust skeletal muscle hypertrophy. Importantly, mice with skeletal muscle-specific transgenic expression of PGC-1α4 show increased muscle mass and strength and dramatic resistance to the muscle wasting of cancer cachexia. Expression of PGC-1α4 is preferentially induced in mouse and human muscle during resistance exercise. These studies identify a PGC-1α protein that regulates and coordinates factors involved in skeletal muscle hypertrophy.
Duke Scholars
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Related Subject Headings
- Transcription Factors
- Trans-Activators
- Resistance Training
- Protein Isoforms
- Physical Conditioning, Animal
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
- Myostatin
- Muscle, Skeletal
- Muscle Fibers, Skeletal
- Molecular Sequence Data
Citation

Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Transcription Factors
- Trans-Activators
- Resistance Training
- Protein Isoforms
- Physical Conditioning, Animal
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
- Myostatin
- Muscle, Skeletal
- Muscle Fibers, Skeletal
- Molecular Sequence Data